DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	201/832 - (24%)
Similarity:	348/832 - (41%)	Gaps:	204/832 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYTRLA---VCILICVILNDC-----------------------EARSIG----DESHENAITDE 46
            :|||..   |.::.|..|..|                       |.:::|    :|..:.....:
Worm     1 MYTRFGPPIVFLISCYALILCGTVDALPRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGD 65

  Fly    47 TADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQ-- 109
            :..|..:...:.|| :|.|:||||||:|:||..|.:       .|...:.| .||:....|.:
Worm    66 SEGYQEASRLLQKS-LNLSLDPCDDFFEYACRAWVD-------SHPIPDDL-TSYSQFTATREKV 121

  Fly   110 LLTRTKLAE---ALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNA 171
            |....||.|   ::..|..:.:.::.||:|:..|......|.. .|..|::.|.:|.|..:.|..
Worm   122 LAEMRKLYEDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARD-LLEKIKTYGYWPMVHNEKWRE 185

  Fly   172 SSFSWFNMSAHLSNYGVRSLIHEEILPQHPFNP------------YFKLPELGFDHVVHTAHVAN 224
            |:   |:::..|||    ::...::.....|.|            .|....||..:
Worm   186 ST---FDLTKLLSN----TIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLGLGY--------- 234

  Fly   225 TSSRAYQLNEHRMRGYLKEYN-----------------LTKDEISAVIEGVFAF---WSEALSIE 269
             |:|.|.|:|.:....:|.|.                 :.:.:|.:.::.:.||   |::.|..|
Worm   235 -STRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVAE 298

  Fly   270 DKFESDRDKCDLLSEIEEVPRFGQWRSYYEIA-WNGI----------DFYNGSSGGEFCDFYYVE 323
            :    ||..   .:::..|.||...:.|..|. |..:          .:...:......|..|::
Worm   299 E----DRRN---YTKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQ 356

  Fly   324 LDKVCAKHTE--AVANYLAMR-------------------FLYRMDDKLKEPKQPEDQKVNCLMI 367
            ......::|:  .|.||:.:|                   |.::|..:    ||.:.:..:|:..
Worm   357 KMNTLLQNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGR----KQRQPRWKDCVSS 417

  Fly   368 VQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPV 432
            ....|......:|:.::|.....:...||:|::::|.|.::.:.:|:||||:..||.|
Worm   418 AGGKLSYASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMHANDWMDAETKKYALEK------- 475

  Fly   433 IGSYKNEELSDTLIREINNLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKDTKPLTLLVGM 497
                     :|.::::|        .|...::|...|..:   |.||  :..|:|:....:...:
Worm   476 ---------ADQMLKQI--------GYPDFILNDEKLDDW---YKGL--EGAPEDSFSQLVEKSI 518

  Fly   498 Q-------------------------VNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGY 537
            |                         |||||....|::...||:|..|.:...:|.:|.:|.||.
Worm   519 QWRNNFYYRRLLEPVNRFEFISSAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGA 583

  Fly   538 LIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRD 602
            :||||:|||||..|..||:.|.:||||...:.:.|.||.||.::.:....:...:..|.|..|:.
Worm   584 VIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQG 648

  Fly   603 ENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLD-LSPEQLFFVGFAQLWCADYE 666
            |||||.||::.|...|:::   |::.|.       :..::|..: |:.|||||||:||:||....
Worm   649 ENIADNGGIKQAFKAYKSY---LEKHGG-------QEARLPQFESLTNEQLFFVGYAQVWCGAKT 703

  Fly   667 PE-HYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            || .....||..|:.:..||...::|..:|||.:|||.||||:| .:.|.:|
Worm   704 PETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNP-TKRCVVW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	188/752 (25%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	184/744 (25%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	187/750 (25%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	184/742 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850