DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-26

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	817	Identity:	185/817 - (22%)
Similarity:	286/817 - (35%)	Gaps:	296/817 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISY----TLMDVTEQLLTRTKLAEALN---- 121
            ||:|||:||:||||.|.|     ||       :::.|    ||.:.  |.....::.:|::
Worm   123 SVEPCDNFYQFACGGWIN-----QS-------VNLKYDSWNTLYET--QRTAHDQIVQAMHKIND 173

  Fly   122 ------VSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFP----------------AV 164
                  .:|....|.:.|..|:..:...:.... .:...:..|||:.                .:
Worm   174 GSYPLPTNAGERAAAKMYEQCMDTDTLEQTGLH-LWERFVDELGGWMPELKNGALEQEESFEIEL 237

  Fly   165 DRD---------------AWNASSF---------SWFNMSAHLSNYGVRSLIHEEILPQHPFNPY 205
            |.|               |:|.|.|         ::.|...||..      |:|::       |.
Worm   238 DEDEKKRRRFEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLIT------IYEQL-------PI 289

  Fly   206 FKLPE------------------------------------LGFDHVVHTAH--VANTSSRAYQ- 231
            ...||                                    ||||.......  :||.....||
Worm   290 LLAPEKYHYNKELTPEMIYGKMEGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIANMIYLEYQI 354

  Fly   232 -----------------------------LNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSEALS 267
                                         :|.|.....|...||:..|..|:..|  ..|...||
Worm   355 TMAGSTFYKEKKERYTVVMLRELQEIAPAINWHYFLSRLVGENLSHSEPIALKTG--TQWIPILS 417

  Fly   268 -IEDKFESDRDKCDLLSEIEEVPRFGQWRS-YYEIA-----------WNGIDFYNG--SSGGEFC 317
             |.:|.:..|      |.:..:..:.:|:: .:.:|           |..:..|:|  |...|||
Worm   418 AIVEKLKQSR------SGVAVLKNYVKWKTIMFHLAYASPKCRDGLLWMAVSLYSGAASQRKEFC 476

  Fly   318 DFYYVELDKVCAKHTEAVANYLAMRFLYRMDDKLKEPKQPEDQKVNCLMIVQMTLPNLFNRLYMA 382
                                      :.|:..                 |..::||::..::...
Worm   477 --------------------------VLRLSG-----------------IFPLSLPSILRKIDGI 498

  Fly   383 EHFTDEKH----SEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIG-------SY 436
            :|  .||:    ..|:|.:.|  |.:..:..|..:.|.|||...:.|...:|..||       .|
Worm   499 DH--TEKNVKAVQNIADRIQE--KYEEMVRSSNLFSDRETRENVIDKVNNMTKFIGFPDAMRSDY 559

  Fly   437 KNEE----LSDTLIREINNLTIVEGS---YAQSLINLRVLGTYLHRYAGLHADELPK---DTKPL 491
            :.|:    |.|||.     .::|.||   |.:.|..||           |..|  |:   ||:|
Worm   560 EMEKEAVRLHDTLF-----WSMVLGSSSVYKERLQRLR-----------LPVD--PRSWVDTRP- 605

  Fly   492 TLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDS 556
                .:.|.|..|. .|.|.:....|..|.......|...:..||.:|||||||.||.:|.....
Worm   606 ----AISVPAHNYE-RNLVQIPFDSLRLPYADEHQLDFANYAGIGTIIGHELTHAFDGQGKLHGP 665

  Fly   557 AGEVRDWWSRKSEAVFQERAQCYVDYFNQYL-IPEINQTIRGNETRDENIADAGGLRAALTGYRN 620
            .|.:..|||..|...|:.|.||:|   .||. :.:.:......|...|||||..||:.|...:::
Worm   666 TGNLGVWWSTDSIREFKAREQCFV---KQYAGLMDSHDMNAAKEGLYENIADQVGLKVAYEAWKS 727

  Fly   621 HMKQLQRSGADGETLAHKNEQMPGLD-LSPEQLFFVGFAQLWCA----DYEPEHYWEELTGAHTV 680
            :..  |.||           :||||: .|.:||||:.:.|.|||    .|:.:.:.||
Worm   728 NGN--QNSG-----------RMPGLEKYSQDQLFFLAYTQGWCALRSKSYKLQPHMEE------- 772

  Fly   681 DKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
             :.|:||::.|:.:||..:||...|.|:| .:.|.:|
Worm   773 -RIRMLGSLQNSPEFASAWKCSSESFMNP-PDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	184/815 (23%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	182/812 (22%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	184/815 (23%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	182/812 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020