DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-5

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001364754.1	Gene:	nep-5 / 173933	WormBaseID:	WBGene00017393	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	768	Identity:	153/768 - (19%)
Similarity:	281/768 - (36%)	Gaps:	199/768 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPLYTRLAVCILICVILNDCEARSIG----DESHENAI---------TDETADYLRSHGAMMKSY 61
            |.:.|.|.:.:|:...|.......|.    :...:.|:         |.|...|    .|.:...
Worm    63 LAVITTLVILVLLIFALGALGLHDISAFKWEPKPQKALRIMLDLPCQTKECVKY----SAELLEL 123

  Fly    62 MNFSVDPCDDFYEFACGNW-----------KNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTK 115
            |:.||:||::|:...|..:           |.:....:..||::         ::|..::|::.
Worm   124 MDSSVNPCENFHHHVCNGFNPRKKDFERLMKLINIQEKPDHRKA---------VNVVRRMLSKC- 178

  Fly   116 LAEALNVSAELLVAQRFYNSCLAAELFP-------RPAADPAYLSVIRSLGGFPAVDR------- 166
               |:..:.|:....|..:..|....||       :| :||...|...:...:|.:.:
Worm   179 ---AMGKTEEIHQVGRLSSIILPGLPFPLLNNSWTKP-SDPISTSNSSTTYSYPFLTKILAHIIL 239

  Fly   167 ----DAW-------NASSFSWF---NMSAHLSNYGVRSLIHEEILPQH-PFNPYFKLPELGFDHV 216
                ||.       :.|.||.|   ..|..|:|:..|::.  :||.:: |.:....:.:|.||
Worm   240 HNPDDAGFVGIKPSSDSEFSLFVVKPFSPVLTNFKFRNMY--DILKRNAPESSTNGMIDLEFD-- 300

  Fly   217 VHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCD- 280
                       |..|||                              :.:.::.|.|....|.|
Worm   301 -----------RQRQLN------------------------------DVIKLQTKLEKIEFKADP 324

  Fly   281 ---LLSEIEEVPRFGQWRSYYEIAW--NGIDFYNGSSGGEFCDFYYVELDKVCAK-HTEAVANYL 339
               .|:||:.......|:...: :|  ||.........| |...||.|::.:.:. .:|.:.|:|
Worm   325 EVVNLTEIQRQMPIIDWKRLID-SWIPNGYAHLKEKVYG-FNTSYYEEINAIISSTPSETIYNFL 387

  Fly   340 AMRFLYRMDDKLKEPKQPEDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQ 404
            .:||.:    |....:...|.:..||..:..|:|... .||.:|.  .|..:.::.|:..::...
Worm   388 FLRFSF----KFLRTEVASDLEDTCLHQLSTTIPGKI-VLYGSEE--PEALNLLNGMLHTIKDQL 445

  Fly   405 RQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLINLRVL 469
            ::.|.:::|:|:....|| .|:...|..:..:..|:|.|.|:.:|.    .|.:|..:|.|:.:.
Worm   446 KRSLATLKWMDSRGIEEA-QKKFNKTKTVFGFTGEDLIDELVGKIT----PESNYISTLQNVLLW 505

  Fly   470 GTYLHRYAGLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGT 534
            .|          ..:.|......:.|.:....||....|.:.:...:||.|....:.|:...|.|
Worm   506 QT----------RNMFKSVAENNVTVFLNSEVFYSVEKNEITISRALLHYPFMSANLPNYTNFAT 560

  Fly   535 IGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNE 599
            |...|..::.|.||..|..:||.|..|:||:.::|..||...||:
Worm   561 IASKILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCF-------------------- 605

  Fly   600 TRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGL-DLSPEQLFFVGFAQLWCA 663
              |..:.:..|:..:: |:..:           ::.......:||: ..|.|.|||....:..|
Worm   606 --DGMMQNVFGVSVSI-GWNAY-----------DSTKEPYATLPGIQQSSDEALFFYSMVKTMC- 655

  Fly   664 DYEPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRM 716
                           |.|...|..|:::...|...:||..|:.|:|..: |::
Worm   656 ---------------TSDPDNVNEALASVPQFNSAFKCNNGTKMNPPTK-CKL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	142/705 (20%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	139/696 (20%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	139/696 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920