DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-12

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	205/776 - (26%)
Similarity:	346/776 - (44%)	Gaps:	127/776 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILICVILND-----------C-----EARSIGDESHENAITDE----TADYLRSHGAMMKSYMNF 64
            |.|..||:|           |     :|..:.:.:|.|..:|.    |.:.:|...:.:.: ||.
Worm   106 ITIVAILSDGFSTLISGSELCSNTEGDAYEVKNSNHVNYGSDNSTCLTPECIRLAASYLNN-MNR 169

  Fly    65 SVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVA 129
            ..:||:||||||||.:...|...:...:.:.:.::...:....:.:|.:|...   |.:..:.:|
Worm   170 DANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKKEMDRHLKDILEKTSRE---NTTRSMKLA 231

  Fly   130 QRFYNSCL----AAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGV-- 188
            |.:::||:    ..:|..:|     .:|:|.:|||:|.:....:::..|.|..::.||:.|||
Worm   232 QIYFDSCMDEFSQDDLGVQP-----LMSMISNLGGWPLLTNARFDSIDFQWEVLAGHLALYGVDG 291

  Fly   189 --RSLIH-------EEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEY 244
              |..:|       :.:|...|  |...|.:..|...|.:::|.....|.|.|:...:.|...|
Worm   292 IFRVFVHSSFDDSDKNVLMFSP--PKLFLEKKKFYREVPSSNVYLQYYRQYILSLLSLLGVDME- 353

  Fly   245 NLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDLL--------SEIEEVPRFGQW-RSYYEI 300
                || :.|||         ..::|..:.:|...:|.        |.|..:..||:: |.|.:|
Worm   354 ----DE-TGVIE---------YQVDDIIDFERRIANLTRIELSRNHSSINNMITFGEFKRKYDKI 404

  Fly   301 AWNGIDFYNGSSGGEF-----------CDFYYVE--LDKVCAKHTEAVANYLAMRFLYRMD---- 348
            .|:.  |:|....|..           .|..|.:  ...:.:|...::.|:|....:...|
Worm   405 NWDA--FFNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDMYLP 467

  Fly   349 DKLKEPKQPEDQKVN-----------CLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRK 402
            .|.::|.....||:.           |:..|:..|....:..|..:.||.:......||:.:::|
Worm   468 AKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKK 532

  Fly   403 AQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDT-LIREINNLTIVEGSYAQSLINL 466
            |..|.|.:.:|:|..||..||.|...:...|| :.:..|::| ::.....:.:....|..:.|:|
Worm   533 AMEQTLLNADWIDESTREAALMKLDAMGHKIG-FPDSLLNETAVLLPYAGVRLTANQYFDNAISL 596

  Fly   467 RVLGTYLHRYAGLH-ADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSL 530
            : ...|....:.|| ...|.....|:     :.|:||:|...|.:...||:|..|.:....|...
Worm   597 K-KAAYRDALSKLHRTPSLIDWASPI-----IAVDAFHYFTGNEIIFPAGILQFPMFVPDAPAFS 655

  Fly   531 KFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTI 595
            .:|.||..||||:|||:|..|:.:|..|.:|.||..::...||::.||:|..:...:.|:..:.:
Worm   656 NYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKV 720

  Fly   596 RGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGL-DLSPEQLFFVGFAQ 659
            .|..|..|||||.||||.|...|     || ||..:.||     .::||| |.||.||||:.:|.
Worm   721 DGKMTIGENIADNGGLRVAFQAY-----QL-RSDREKET-----RRLPGLTDFSPNQLFFLAYAN 774

  Fly   660 LWCADYEP---EHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            .||...:|   :|..:  |..|::..:||...:.|...|::.:.||:||||:| .|.||:|
Worm   775 TWCEALKPSAIDHIMD--TDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNP-FEKCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	192/714 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	188/706 (27%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	188/706 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920