DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Mme

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	786	Identity:	202/786 - (25%)
Similarity:	351/786 - (44%)	Gaps:	140/786 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLYTRLAVCILICVILNDCEARSIGDESHENAIT--------DE----TADYLRSHGAMMKSYMN 63
            ||...|:|.:|:..|:               |:|        |:    ::|.::|...:::: |:
Mouse    26 PLEISLSVLVLLLTII---------------AVTMIALYATYDDGICKSSDCIKSAARLIQN-MD 74

  Fly    64 FSVDPCDDFYEFACGNW--KNVKTPRQSPHRRSNIL--DISYTLMDVTEQLLTRTKLAEALNVSA 124
            .||:||.||:::|||.|  :||.....|.:...:||  ::...|.||.::..|...:|
Mouse    75 ASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVA------- 132

  Fly   125 ELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNAS-SFSWF---NMSAHLSN 185
             :..|:..|.||:...........| .|.::..:.|:| |..|.|:.: ..||.   :::...|.
Mouse   133 -VQKAKTLYRSCINESAIDSRGGQP-LLKLLPDIYGWP-VASDNWDQTYGTSWTAEKSIAQLNSK 194

  Fly   186 YGVRSLIH------EEILPQHPFNPYFKLPELGF---DHVVHTA--HVANTSSRAYQLNEHRMRG 239
            ||.:.||:      ::...||..  :|..|.||.   |:...|.  ..|.|:...:.::..|:..
Mouse   195 YGKKVLINFFVGTDDKNSTQHII--HFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIR 257

  Fly   240 YLKEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDLLSEIEEVPRFGQWRSYYEIAWNG 304
            ..:...:.::::|..:..|.....|..:...|.|...|...|.:::    ...:.::.:.:..||
Mouse   258 QEQSLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKM----TLAKLQNNFSLEVNG 318

  Fly   305 -----------------IDFYNGSSGGEFCDFYYVELDKVCAKHT-EAVANYLAMRFLYRMDDKL 351
                             |:..|......:...|..:|..:..|:: ..:.|.::.||:..:...|
Mouse   319 KSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSL 383

  Fly   352 ----KEPKQPEDQKV-----------NCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMR 401
                ||.:....:.:           .|...|...:.|...|||:...|..|....:.|::.::|
Mouse   384 SRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIR 448

  Fly   402 KAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIREINN----LTIVEGSYAQS 462
            :...|.|:.:.|:||||:.:|..|...|...|| |.::.:|:.  .::||    |...|..|.::
Mouse   449 EVFIQTLDDLTWMDAETKKKAEEKALAIKERIG-YPDDIISNE--NKLNNEYLELNYREDEYFEN 510

  Fly   463 LI-NLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ--------VNAFYYNLDNSVYVMAGVLH 518
            :| ||:.              ...|..|.|...|...        |||||.:..|.:...||:|.
Mouse   511 IIQNLKF--------------SQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQ 561

  Fly   519 PPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYV-DY 582
            ||.:.....:||.:|.||.:||||:|||||..|.:|:..|::.|||:::|...|::::||.| .|
Mouse   562 PPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQY 626

  Fly   583 FNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDL 647
            .|........|.:.|..|..|||||.||:..|...|:|::|:      :||     .:.:|||||
Mouse   627 GNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKK------NGE-----EKLLPGLDL 680

  Fly   648 SPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKA 711
            :.:||||:.|||:||..|.||:....: |..|:...:|::|.:.|:.:||:.:.|...|.|:|:
Mouse   681 NHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPE- 744

  Fly   712 ESCRMW 717
            ..||:|
Mouse   745 RKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	190/723 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	186/715 (26%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	186/715 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.800