DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-10

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_494532.2	Gene:	nep-10 / 173684	WormBaseID:	WBGene00017555	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	173/743 - (23%)
Similarity:	293/743 - (39%)	Gaps:	158/743 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NDCEARSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNWKNVKTPRQS-- 89
            |.||:......:||                 :.:|.:.|||||.|||:..||.:.......|.
Worm    75 NVCESPECITLAHE-----------------LHNYKDPSVDPCQDFYQHFCGKFYEHSAIGQGRM 122

  Fly    90 PHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRFYNSCLAAE-------LFPRPAA 147
            ..:||       ||..:..:.|.:.|.:.:.:.:    ..::.|..|...:       :.|:...
Worm   123 ATKRS-------TLSKLIREFLLKNKTSTSKSEN----TMKQVYAKCRELQKISDLNSIPPQALL 176

  Fly   148 DPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIHEEILPQHPFNPYFKLPELG 212
            |  ..|.|:.:|.:|.:|:| |:.|.|:...|...|.|.|.                    ..||
Worm   177 D--IFSDIKKIGAWPVLDKD-WDGSKFNLNEMLRQLVNLGE--------------------THLG 218

  Fly   213 FDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRD 277
            |.|....|       |.|.|    ::..||: .:.|..:..|::.:..  :..:.::..|..|.|
Worm   219 FFHFDFIA-------RPYVL----IKPPLKQ-GVQKSVLEKVVKMILE--ANEIKMDQGFSEDLD 269

  Fly   278 KCDLLS---EIEEVPR-----FGQWRSYYEIAWNG--IDFYNGSSGGEFCDFYYVELDKVCAKH- 331
            :...||   :|:::||     .|.......|.:.|  ::....|....|....:   .||...|
Worm   270 EYFELSNRIKIDKLPRTSRSIVGLLPDVRRINFRGLILEMMPRSKMNRFLGTLF---QKVVTYHH 331

  Fly   332 --------------------TEAVANYLAMRFLYR----MDDKLKEPKQPEDQKVNCLMIVQMTL 372
                                ..|:||||...|::.    :...||..::      .|..||...|
Worm   332 PLFVRDNETNHLDTIIRSTSNRALANYLIFNFIHSSIKFLTFGLKSDRE------RCEKIVVQEL 390

  Fly   373 PNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAET---RAEALSKEAGITPVIG 434
            |....|::| .:..|:.:.|....:||..|  ..:||.:...|:.|   :...|.|...|..:||
Worm   391 PRPSLRVFM-RNCVDKGNREEVAKLTETVK--ENVLEMIRESDSFTPSVKKRVLKKVEAIGAIIG 452

  Fly   435 SYKNEELSDTLIREINNLTI-VEGSY---AQSLINLRVLGTYLHRYAGLHADELPKDTKPLTLLV 495
            ...:.:...||.:|..|||: ...||   :|.|..||:    .|:...| |.:.|.......|
Worm   453 YPDHFDPPGTLDKEYENLTLDASDSYYKMSQKLHQLRL----QHQMEFL-AGQTPLSPSDQVL-- 510

  Fly   496 GMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEV 560
              :|||.|.:.||::.|:|..|..|.:..::|:.:.....|:|||||..|..|.:....|.
Worm   511 --EVNAHYDSKDNALTVLAPFLDDPFFDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRDG---- 569

  Fly   561 RDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQL 625
              |:..:....:.:||||.:|.::.|..|:..:.:.|.....|.:.|..|.......:    |::
Worm   570 --WYKTEDMTEYGKRAQCLIDQYDNYDDPDHGKQMNGTYCIGEIVGDWVGRDVTWRAF----KKM 628

  Fly   626 QRSGADGETLAHKNEQMPGL-DLSPEQLFFVGFAQLWCADYEPEHYWEELTGAHTVDKYRVLGAV 689
            ..|         |.:::.|. |.:.:||:|...:..:|.....:...:.|:..|..:.:||.|..
Worm   629 DLS---------KMQKLIGFEDKNLDQLYFRIQSLFFCGPRSMKSLEQLLSDPHPTEVFRVNGIY 684

  Fly   690 SNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            ||...||:.:.||:||||:|: :.|:|:
Worm   685 SNMPQFAKAFNCPIGSPMNPE-KKCKMF 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	167/708 (24%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	164/700 (23%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	164/700 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920