DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-13

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001342017.1	Gene:	nep-13 / 173672	WormBaseID:	WBGene00018196	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	777	Identity:	178/777 - (22%)
Similarity:	325/777 - (41%)	Gaps:	164/777 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VCILICVIL-------------NDCEARSIGDESHENAITD--ETADYLRSHGAMMKSYMNFSVD 67
            :.|:||:::             .|...::|....| |...|  :||:.:.....:: ::.|.::|
Worm    43 ISIIICLVIIAICMGAVIVFWRMDSAPQAICKTDH-NKTRDVCKTAECITLSSTLL-NWQNTNID 105

  Fly    68 PCDDFYEFACGNWKNVKTPRQSPHR-----RSNILDISYTLMDVTEQLLTRTKLAEALNVSAELL 127
            ||:||||::||        |...|.     |:|..|.  .:|.:..|.:.:.:...:.:.:|.:|
Worm   106 PCEDFYEYSCG--------RYQEHTLNDGIRANEKDT--IVMKLIRQFVLKNQSTTSNSENALML 160

  Fly   128 VAQ------RFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNY 186
            :.:      |..|.....|:..|...:.     ||.:|.:|..|:: ||:|.|:..||.:::::
Worm   161 LYEKCSLRYRMENRHQETEVIQREVFEN-----IRKIGSWPIADKN-WNSSHFNLNNMLSNMAS- 218

  Fly   187 GVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLT---K 248
                 ||  :||       |.|    |:..|...:..||:::...:...:::..:.:..|.   :
Worm   219 -----IH--MLP-------FGL----FETRVIELYPMNTTAKQLVIRPTKLKFSIPQEELVRAIR 265

  Fly   249 DEISAVIEGVFAFWSEAL-SIEDKFESDRD----------KCDLLSEIEEV-------------- 288
            |.:|  :.|:.:...:.. .:.:.|..|::          |...|||:::.
Worm   266 DLLS--VNGITSIMKKVKEDVAESFALDKEIGNIHIDPQPKPATLSELQKAVPDIDFERIIKSYL 328

  Fly   289 -PRFGQWRSYYEIAWNG-IDFYNGSSGGEFCDFYYVELDKVCAK-HTEAVANYLAMRFL-YRMDD 349
             |:.|.|.|.....::. .:.:.|.:.         .|..:.|: ....:||||.:::: |....
Worm   329 NPKTGNWSSLRTKIFSARFELFFGKNN---------NLSSIIARTKPRILANYLFLKYIEYAYFF 384

  Fly   350 KLKEPKQPEDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWL 414
            .....|...|... |..:|..:||....|:::..||..|..:..|::|..::.|..:|:.:..||
Worm   385 FFDNTKVFSDDDF-CTEVVTTSLPRASLRVFVRNHFKKENMAVASEIVEVVKTAYVEIINNSTWL 448

  Fly   415 DAETRAEALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLINLRVLGTYLHRYA-- 477
            ...||..|:.|...:..|||..:..|.:..|......|.:   |.:.|..   ||.|.::|:.
Worm   449 HNSTRESAIEKVVKMKKVIGYTEEYERTGALDEMFETLQL---SRSDSFF---VLMTKVNRFKIE 507

  Fly   478 ----GLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYL 538
                .:.:|.|....:||.:     .||||:...|.:.|:...|..|.:...:|..:....:|.:
Worm   508 QLMDFVSSDSLLNPIEPLVM-----ANAFYFPTKNLLNVLVPFLDKPLFDFKYPRYVAMAGVGRV 567

  Fly   539 IGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDE 603
            :.||:.|.||..|...|..|..||||:|:....:..|::|:.:.|..:..|.......|.|...|
Worm   568 LAHEIGHAFDINGRQTDEIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSFKGKQNGTEVLAE 632

  Fly   604 NIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQ------------LFFVG 656
            .||||.|:.|:...::.                        ::|:.||            |:|..
Worm   633 IIADALGMEASWIAFKK------------------------INLTEEQGLIQFEDHDFGKLYFQV 673

  Fly   657 FAQLWCADYE-PEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            .|..:||... .|.|.::|  :|..:|:|:.||.||:..||:.||||:||.|:| .:.|.|:
Worm   674 AALDFCAPSRIEERYSDQL--SHPTNKFRINGAFSNSRAFADTYKCPVGSKMNP-VQRCDMF 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	167/718 (23%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	165/710 (23%)
nep-13	NP_001342017.1	M13	104..729	CDD:189000	165/709 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920