DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	805	Identity:	204/805 - (25%)
Similarity:	321/805 - (39%)	Gaps:	178/805 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPLYTRLAVCIL--------ICVILNDCEARSI--------GDESHENAITDETADYLRSHGAMM 58
            ||.:.|..||:|        :|.||....|...        |....|..  .|...:.|: ...:
Mouse    52 LPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGGGGACPEGC--PERKAFARA-ARFL 113

  Fly    59 KSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILD--ISY-TLMDVTEQLLTRTKLAEAL 120
            .:.::.|:|||.|||.||||.|.          ||..|.|  ::| |:..:.||...|.:...|.
Mouse   114 SANLDASIDPCQDFYSFACGGWL----------RRHAIPDDKLTYGTIAAIGEQNEERLRRLLAR 168

  Fly   121 NVSAELLVAQR----FYNSCL----AAELFPRPAADPAYLSVIRSLGGFP---AVDRDA---WNA 171
            ........|||    |:.|||    ...|.|||     .|.||...||:.   |.||..   |:.
Mouse   169 PTGGPGGAAQRKVRAFFRSCLDMREIERLGPRP-----MLEVIEDCGGWDLGGAADRPGAARWDL 228

  Fly   172 -----------SSFSWFNMSAHL-----SNYGVRSLIHEE--ILPQHPFNPYFKLPE-------- 210
                       |:.:.|:::..|     |.|.:|  |.::  .||:...  |....|
Mouse   229 NRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIR--IDQDGLTLPERTL--YLAQDEESEKILAA 289

  Fly   211 -----------LGFDHVVHTA--------HVANTSSRAYQLNEHRMRGYLKEYN-LTKDEISAVI 255
                       ||.|.|...|        .:||.|...|   :...|.....|| :|..::..:|
Mouse   290 YRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEY---DDLRRDVSSAYNKVTLGQLQKII 351

  Fly   256 EGVFAFWSEALSIEDKFESDRDKCDLLSEIEEVPRFGQWRSYYEIAWNGIDFYNGSSGGEFCDFY 320
            ..:...|    .::..|:.|      .||.|||....                        .|:.
Mouse   352 PHLQWKW----LLDQIFQED------FSEEEEVVLLA------------------------TDYM 382

  Fly   321 YVELDKVCAKHTEAVANYLAMRFLYRMDDKLKEP---------------KQPEDQKVNCLMIVQM 370
            ......:.:.....:.|||..|.:..:.:.|..|               .:|::....||.....
Mouse   383 QQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANR 447

  Fly   371 TLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGS 435
            ........|::.|||:....:::..:|.:::....|.||.::|:||:|:|.|.:|...:..::|
Mouse   448 HFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVG- 511

  Fly   436 YKNEELSDTLIREINNLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKDT-KPLTLLVGMQV 499
            |.:..|....:.:.....:.|.:|.::::|      .:.....|...::.::. |...||....:
Mouse   512 YPDFLLKPEAVDKEYEFEVHEKTYFKNILN------SIRFSIQLSVKKIRQEVDKSSWLLPPQAL 570

  Fly   500 NAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWW 564
            ||:|....|.:...||:|.|..|...:|.||.:|.||.:||||||||:|..|..:|.:|.:..||
Mouse   571 NAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWW 635

  Fly   565 SRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSG 629
            :..|.:.|..:|:|.|..::.:.:  .||.:.|..|..|||||.|||:.|...|:..:::
Mouse   636 TETSYSHFLRKAECIVRLYDNFTV--YNQRVNGKHTLGENIADMGGLKLAYYAYQKWVRE----- 693

  Fly   630 ADGETLAHKNEQ-MPGLDLSPEQLFFVGFAQLWCADYEPEH-YWEELTGAHTVDKYRVLGAVSNN 692
                   |..|. :..|..:..||||:.|||.||.....:. |.:.||..|..:.|||||:||..
Mouse   694 -------HGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQF 751

  Fly   693 DDFAEVYKCPLGSPMHPKAESCRMW 717
            ::|...:.||..|||:| ...|.:|
Mouse   752 EEFGRAFHCPKDSPMNP-VHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	189/737 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	187/729 (26%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52		204/805 (25%)
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	187/729 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840