DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	766	Identity:	207/766 - (27%)
Similarity:	338/766 - (44%)	Gaps:	134/766 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LAVCILICVILNDCEARSIG-----DESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEF 75
            ||..:|.|::       ::|     |.||...:|:..   :|..|.:::| ::..|.||:|||:|
Human   188 LAALLLGCLV-------ALGVQYHRDPSHSTCLTEAC---IRVAGKILES-LDRGVSPCEDFYQF 241

  Fly    76 ACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAEL-LVAQRFYNSCLAA 139
            :||.|.. :.|......|.|..:   :|.|..:.:|.........|.|:|. ...||||.|||..
Human   242 SCGGWIR-RNPLPDGRSRWNTFN---SLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQV 302

  Fly   140 ELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIHEEILP----QH 200
            |......|.| ...:|..:||:...  ..|:..:|.                   |:|.    .:
Human   303 ERIEELGAQP-LRDLIEKIGGWNIT--GPWDQDNFM-------------------EVLKAVAGTY 345

  Fly   201 PFNPYFKLPELGFDHVVHTAHVANTS-------SRAYQL----NEHRMRGYL---KEYNL----- 246
            ...|:|.: .:..|.....::|....       ||.|.|    ||..:..||   :|..:
Human   346 RATPFFTV-YISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGR 409

  Fly   247 ---TKDEISAVIEGVFAFWSEALSIEDKFESDRDKC---DLLSEIEEVPRFGQWRSYYEIAWNGI 305
               |::::..|:|  .......:::......|.:|.   ..:||::.:.....|..:.....:.:
Human   410 PTSTREQMQQVLE--LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPL 472

  Fly   306 DFYNGSSGGEFCDFY---YVELDKVCAKHTE--AVANYLAMRFLYRMDDKLKEPKQPEDQKV--- 362
            :.    |..|....|   |::........||  .:.|||....:.:....|....:...:|:
Human   473 EL----SDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLET 533

  Fly   363 ------NCLMIVQMTLPN-------LFNRLYMAEHFTDEKHSEISD-MVTEMRKAQRQILESVEW 413
                  :|:...|..:.|       ....|::...| |.:..||:: |::|:|.|..:.|..:.|
Human   534 LYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATF-DRQSKEIAEGMISEIRTAFEEALGQLVW 597

  Fly   414 LDAETRAEALSKEAGITPVIG----SYKNEELSDTLIREINNLTIVEGSYAQSLINLRVLGTYLH 474
            :|.:||..|..|...|..:||    ..:.:||.|.    .:...|.|.|:.|:::||      .:
Human   598 MDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDV----YDGYEISEDSFFQNMLNL------YN 652

  Fly   475 RYAGLHADELPK-DTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYL 538
            ..|.:.||:|.| .::....:....|||:|....|.:...||:|..|.|.|:.|.:|.||.||.:
Human   653 FSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVV 717

  Fly   539 IGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEIN-QTIRGNETRD 602
            :||||||.||.:|..:|..|.:|.||..:|.|.|:....|..:.:|||   ::| :.:.|.:|..
Human   718 MGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQY---QVNGERLNGRQTLG 779

  Fly   603 ENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEP 667
            |||||.|||:||...|:..:::      .||     .:|:|.:.|:..|||||||||:||:...|
Human   780 ENIADNGGLKAAYNAYKAWLRK------HGE-----EQQLPAVGLTNHQLFFVGFAQVWCSVRTP 833

  Fly   668 EHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            |...|.| |..|:..::||||.:||:.||...:.||:||||:| .:.|.:|
Human   834 ESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNP-GQLCEVW 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	195/715 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	193/707 (27%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	193/707 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850