DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Ece2

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	781	Identity:	204/781 - (26%)
Similarity:	342/781 - (43%)	Gaps:	141/781 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SYFRLPLYTRLAVCILICVILNDCEARSI-GDESHENAITDETADYLRSHGAMMKSYMNFSVDPC 69
            |:.:|.|.....:.:|..::|....|..: .|.:|...:|:..   :|..|.:::| ::..|.||
Mouse    55 SHTQLELVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEAC---IRVAGKILES-LDRGVSPC 115

  Fly    70 DDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQR--- 131
            .|||:|:||.|.. :.|..:...|.|..:   :|.|..:.:|.........|.|:|   |:|
Mouse   116 QDFYQFSCGGWIR-RNPLPNGRSRWNTFN---SLWDQNQAILKHLLENTTFNSSSE---AERKTR 173

  Fly   132 -FYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIHEE 195
             ||.|||.:|...:..|.| ...:|..:||:...  ..|:..||    |.           :.:.
Mouse   174 SFYLSCLQSERIEKLGAKP-LRDLIDKIGGWNIT--GPWDEDSF----MD-----------VLKA 220

  Fly   196 ILPQHPFNPYFKLPELGFDHVVHTAHVANTS------------SRAYQL----NEHRMRGYLKEY 244
            :...:...|:|.:      :|...:..:|::            ||.|.|    ||..:..|| :|
Mouse   221 VAGTYRATPFFTV------YVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYL-DY 278

  Fly   245 NL------------TKDEISAVIEGVFAFWSEALSIEDKFESDRDKC---DLLSEIEEVPRFGQW 294
            .:            |::::..|:|  .......:::......|.:|.   ..:||::.:.....|
Mouse   279 MVELGVLLGGQPTSTREQMQQVLE--LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDW 341

  Fly   295 RSYYEIAWNGIDFYNGSS------GGEFCDFYYVELDKVCAKHTE--AVANYLAMRFLYRMDDKL 351
            ..:.....:.::.  |.|      |.|     |::........||  .:.|||....:.:....|
Mouse   342 LEFLSFLLSPLEL--GDSEPVVVYGTE-----YLQQVSELINRTEPSILNNYLIWNLVQKTTSSL 399

  Fly   352 KEPKQPEDQKV----------------NCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISD-MVTE 399
            .:..:...:|:                .|:......|......|::...| |.:..||:: |:.|
Mouse   400 DQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATF-DRQSKEIAEGMINE 463

  Fly   400 MRKAQRQILESVEWLDAETRAEALSKEAGITPVIG----SYKNEELSDTLIREINNLTIVEGSYA 460
            :|.|..:.|..:.|:|.:||..|..|...|..:||    ..:.:||.|.    .:...:.|.|:.
Mouse   464 IRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDV----YDGYEVSEDSFF 524

  Fly   461 QSLINLRVLGTYLHRYAGLHADELPK-DTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHR 524
            |:::||      .:..|.:.||:|.| .::....:....|||:|....|.:...||:|..|.|..
Mouse   525 QNMLNL------YNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAH 583

  Fly   525 SWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIP 589
            :.|.:|.||.||.::||||||.||.:|..:|..|.:|.||..:|...||....|..:.::||
Mouse   584 NHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQY--- 645

  Fly   590 EIN-QTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQ-MPGLDLSPEQL 652
            ::| :.:.|.:|..|||||.|||:||...|:..:::            |..|| :|.:.|:..||
Mouse   646 QVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRK------------HGEEQPLPAVGLTNHQL 698

  Fly   653 FFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRM 716
            |||||||:||:...||...|.| |..|:..::||||.:||:.||...:.||:||||:| .:.|.:
Mouse   699 FFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNP-GQLCEV 762

  Fly   717 W 717
            |
Mouse   763 W 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	192/724 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	190/716 (27%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	190/716 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950