DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and phex

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_004911718.1	Gene:	phex / 100496470	XenbaseID:	XB-GENE-1012247	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	792	Identity:	208/792 - (26%)
Similarity:	350/792 - (44%)	Gaps:	152/792 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RLAVCILIC------VILNDCEARSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFY 73
            ::|:.:.:|      |:|.......|..:..|..:|.|..:    ..|.::|.||.||||||||:
Frog    22 KVALAVFVCTTGILLVLLLLVSKGLISFQKDEYCLTPECIE----AAASIRSKMNLSVDPCDDFF 82

  Fly    74 EFACGNW--KNVKTPRQS-----PHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQR 131
            ::|||.|  :|......|     |..|:|: |:.  |..:.|:.:::.:.:||:.      ..:.
Frog    83 QYACGGWIEENPIPDDMSNYGIYPWLRTNV-DLK--LKALLEKPISKRRDSEAIQ------KVKT 138

  Fly   132 FYNSCLAAELFPRPAADPAYLSVIR--SLGGFPAVDRD-----AWNASSFSWFNMSAHLSNYGVR 189
            ||.||:...........| .|.:::  || .:|.::.:     .|:...||:....|.|......
Frog   139 FYISCMNETQIEEDDIKP-ILKILKQPSL-RWPVLESNIGSDGKWSERKFSFLQTVADLRRLYST 201

  Fly   190 SL---IHEEILPQHPFNPYFKLPELGFDHVVHTAHVAN-TSSRAYQLNEHRMRGYLKEY------ 244
            |:   ::..|..:...|...||.:.....:.|..::.| |.::.|       |..|.|:
Frog   202 SVFLRVYVAIDDKVSNNFILKLDQASLSLLSHEDYLDNSTIAKKY-------RDALLEFMVDVAV 259

  Fly   245 ----NLTKDE--ISAVIEGVFAFWSEALSIEDKF------------ESDRDKCDLLSEIEEVPRF 291
                |.|:.|  :.|:||           :|.|.            |...:|.::......:|:|
Frog   260 LLGANKTRAETDMKALIE-----------LETKLAQITVPQENRTSEMMYNKMNISELSAMIPQF 313

  Fly   292 GQWRSYYEIAWNGIDF--YNGSSGGEFCDFYYVELDK--------VCAKHTEAVANYLAMRFLYR 346
             .|.||.:   |.|||  |......:..:...|.:.:        :.::....:||||..|.:|.
Frog   314 -DWLSYLK---NIIDFNIYPELKNIDLSENVIVRVPQHFKDLFNIIESEEKRTLANYLIWRLVYS 374

  Fly   347 MDDKLK---EPKQPEDQKV------------NCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDM 396
            ....|.   :.:|.|..::            .|:..|:.::|....:|::..||.::|...:.::
Frog   375 RIPNLSRRFQYRQLEFARILLGTNSLAGRWDRCVNYVENSIPYPVGKLFVDAHFQEDKKDMMEEL 439

  Fly   397 VTEMRKAQRQILESV-EWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIRE-INNLTIVEGSY 459
            |..:|.|...:||.. :|:||||:.:|..|...:...:| |.....:||.:.| |..|...|..|
Frog   440 VDGIRWAFIDMLEKENDWMDAETKIKAKQKAVTVMAKVG-YPEFLFNDTYLNEDIKMLKFSESDY 503

  Fly   460 AQSLI-NLRVLGT----YLHRYAGLHADELPKD---TKPLTLLVGMQVNAFYYNLDNSVYVMAGV 516
            ..::: .|..:..    :|.|       .:||.   |.|.|      |||||....|.:...||.
Frog   504 FGNVLQTLHFISQSDFYWLRR-------NVPKKEWFTNPTT------VNAFYSASTNQIRFPAGE 555

  Fly   517 LHPPAYHRSW----PDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQ 577
            |..|.:   |    |.||.:|.||.::|||.|||||..|..:|..|.:..||:.:||..|:.:..
Frog   556 LQKPFF---WGVQYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKEGNLFSWWTSESEERFKNKTL 617

  Fly   578 CYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQ- 641
            |.|:.:|.|...:....::|.:|..|||||.||:|.:...||..::.|::.         |.|.
Frog   618 CMVEQYNNYYWKQAGLHVKGMKTLSENIADNGGIRESFRAYRKWIEDLRKG---------KEEML 673

  Fly   642 MPGLDLSPEQLFFVGFAQLWCADYEPEHYWEE-LTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGS 705
            :|||||:..||||:.:|.:.|..:..|...:: :.|.|:..::||:||:||.::|.:.:.||..|
Frog   674 LPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGVHSPPQFRVIGAMSNFEEFHKAFSCPKDS 738

  Fly   706 PMHPKAESCRMW 717
            .|:..|.|||:|
Frog   739 KMNRGANSCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	198/739 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	192/731 (26%)
phex	XP_004911718.1	M13	75..741	CDD:341056	189/724 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010