DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and ece2

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_002935189.1	Gene:	ece2 / 100488407	XenbaseID:	XB-GENE-1011916	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	729	Identity:	191/729 - (26%)
Similarity:	316/729 - (43%)	Gaps:	133/729 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GAMMKSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEA 119
            |.::.| ::..:|||.|||:::||.|.. :.|......|.|..:   ::.|..:.:|........
Frog   105 GRILDS-LDRGIDPCQDFYQYSCGGWMR-RNPLPDGRSRWNTFN---SIWDQNQAILKHILENAT 164

  Fly   120 LNVSAEL-LVAQRFYNSCL----AAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNM 179
            .|.|:|. :..||||.|||    ..||..:|..|     :|..:||        ||.|. :|..
Frog   165 FNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLTD-----LIEKIGG--------WNISG-NWRG- 214

  Fly   180 SAHLSNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEY 244
                .|:   ..:.:.:...:...|:|.        |..:|...:::|...|:::..:....::|
Frog   215 ----ENF---MSVLKTVSGTYRATPFFS--------VFVSADSKSSNSNIIQVDQSGLFLPSRDY 264

  Fly   245 NLTKDEISAVIEGVFAFWSEALSIED-----------------KFES-------------DRDKC 279
            .|.|.....|::   |:....:|:.:                 :||:             |.:|.
Frog   265 YLNKTANGKVLD---AYLQYMVSVGELLGGSPGSVDMQMTQILEFETLLANLTVPQDERRDEEKI 326

  Fly   280 ---DLLSEIEEVPRFGQWRSYYEIAWNGIDFYNGSS----GGEFCDFYYVELDKVCAKHTEAVA- 336
               ..:||::.:.....|..|...|.:.:|..:...    |.|     |::.......:|:.:.
Frog   327 YNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVYGKE-----YLQQVSELVNNTDPMLL 386

  Fly   337 -NYLAMRFLYRMDDKLKEPKQPEDQKV----------------NCLMIVQMTLPNLFNRLYMAEH 384
             |||....:.:|...|....:....|:                .||.....||......|::...
Frog   387 NNYLVWNLVQKMSSSLDSRFEKAQDKLLESLYGAKKSCTPRWQTCLSNTDDTLGFALGSLFVKST 451

  Fly   385 FTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIG----SYKNEELSDTL 445
            |.....:....|::|:|.|....|..:.|:|.:||..|..|...|..:||    ....:||.:.
Frog   452 FDKNSKNIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEV- 515

  Fly   446 IREINNLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPK-DTKPLTLLVGMQVNAFYYNLDNS 509
               .:...:.|.::.|:::|      :.:..|.|.|::|.| ..:....:....|||:|....|.
Frog   516 ---YDGFEVSEDAFFQNMLN------FYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNE 571

  Fly   510 VYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQE 574
            :...||:|..|.|..:.|.:|.||.||.::||||||.||.:|..:|..|.:|.||...|...|:.
Frog   572 IVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKN 636

  Fly   575 RAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKN 639
            |.:|.|:.:|.|.:.  .:.:.|.:|..|||||.|||:||...|::.:.:      .||     .
Frog   637 RTECMVNQYNSYTVN--GERVNGRQTLGENIADNGGLKAAYHAYKSWLVK------HGE-----E 688

  Fly   640 EQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPL 703
            :|:||:.|:..|||||||||:||:...||...|.| |..|:..|:||:|.:||:.||||.:.||.
Frog   689 KQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPK 753

  Fly   704 GSPMHPKAESCRMW 717
            |:||:| .:.|.:|
Frog   754 GTPMNP-GKHCDVW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	189/722 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	187/714 (26%)
ece2	XP_002935189.1	M13	115..763	CDD:341056	187/713 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020