DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and ece1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_031762312.1	Gene:	ece1 / 100485607	XenbaseID:	XB-GENE-1014218	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	204/783 - (26%)
Similarity:	347/783 - (44%)	Gaps:	158/783 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPLYTRLAVCILICVILNDCEARSIGDESHENAITDE----TADYLRSHGAMMKSYMNFSVDPCD 70
            |.|...|::.:.:|::....:.|:    ||...:::.    |:..|||        ::.|.|||.
Frog    83 LVLVVLLSLGLFMCLLALSLQYRN----SHRVCLSESCISVTSSILRS--------LDRSADPCQ 135

  Fly    71 DFYEFACGNWKNVK-TPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRFYN 134
            |||:::||.|  :| .|....|.|....:..:.....|.:.|......|. |.:|| ..|||::.
Frog   136 DFYQYSCGGW--IKGNPVPDGHSRWGTFNELWEHNQATMKHLLENSTIET-NSTAE-RKAQRYFQ 196

  Fly   135 SCL----AAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIHEE 195
            :|:    ..||..:|..|     :|:.|||:...  ..|:..:|.             .:|  :.
Frog   197 ACMNETKIEELGAKPLQD-----LIQKLGGWAIT--GPWDRDNFQ-------------ETL--QL 239

  Fly   196 ILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAVIEGVFA 260
            :...:..:|:|.        |..:|...|::|...|:::..:....:|:.|.|.|...|:.|...
Frog   240 VTAHYRTSPFFS--------VFVSADSKNSNSNVIQIDQSGLGLPSREFYLNKTENEKVLTGYLN 296

  Fly   261 FWSE-ALSIEDKFESDRDKCDLLSEIE------EVP---RFGQWRSYYEIAWNGIDFYNGSSGGE 315
            |..: .:.:.....|.|::...:.:.|      .:|   |..:.:.|:::|           .||
Frog   297 FMIQLGVLLGGAENSTREQMQEILDFETTLANITIPQEKRRDEEQIYHKMA-----------AGE 350

  Fly   316 FCD--------------FYYVELDK-----VCAK-HTEAVA------------NYLAMRFLYRMD 348
            ..|              ||.|.:::     |.|| :..||:            ||:....:.:..
Frog   351 LKDLVPAVDWMPFLQTVFYPVAINESEPVVVYAKEYLVAVSGLINSTDKRILNNYMMWNLVRKAS 415

  Fly   349 DKLKEPKQPEDQKV---------NCLMIVQMTLPNLFNRL-------YMAEHFTDEKHSEISDMV 397
            ..|.:..|..::|:         .||...:..:.:..|.|       ::...|.:....:...|:
Frog   416 SFLDQRFQDAEEKLMEVMYGTKKTCLPRWKFCISDTDNNLGFALGAMFVKATFAENSKLQALKMI 480

  Fly   398 TEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKN-----EELSDTLIREINNLTIVEG 457
            .|::.|..:.|.::.|:|.|||..|..|...|..:|| |.|     :||.    :..|:..:...
Frog   481 KEIKAAFEENLSTLTWMDDETRRAAREKAEAIYDMIG-YPNFIMDPKELD----KVFNDYNVTSD 540

  Fly   458 SYAQSLINLRVLGTYLHRY-AGLHADELPK-DTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPP 520
            .|.::       |...:.: |.:.||:|.| .:|....:....|||:|....|.:...||:|..|
Frog   541 FYFEN-------GMRFYNFSARVTADQLRKAPSKDQWSMTPPTVNAYYSPTKNEIVFPAGILQAP 598

  Fly   521 AYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQ 585
            .|..|.|.:|.||.||.::||||||.||.:|..:|..|.:|.||...|...|:::.:|..:.:..
Frog   599 FYTSSSPTALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRPWWKNASVEAFKKQTECITEQYGN 663

  Fly   586 YLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPE 650
            |.:.  .:.:.|.:|..|||||.|||:||...|:|.::   ::||:        :.:|.|.||.:
Frog   664 YTVN--GEPVNGRQTLGENIADNGGLKAAYRAYKNWVR---KNGAE--------QLLPSLGLSND 715

  Fly   651 QLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESC 714
            |||||||||:||:....|...|.| |..|:..::||:|:|||:.:|||.::||.||||:|: ..|
Frog   716 QLFFVGFAQVWCSVRTSESSHEGLITDPHSPSRFRVIGSVSNSQEFAEHFRCPPGSPMNPR-NKC 779

  Fly   715 RMW 717
            .:|
Frog   780 EVW 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	192/727 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	190/719 (26%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	190/719 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010