DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and LOC100332538

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_021322193.1	Gene:	LOC100332538 / 100332538	-ID:	-	Length:	808	Species:	Danio rerio

Alignment Length:	802	Identity:	203/802 - (25%)
Similarity:	338/802 - (42%)	Gaps:	172/802 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YTRLAVCIL--------ICVILNDC-------EARSIGDESHENAITDETADYLRSHGAMMKSYM 62
            ::|..:|:|        :||||. |       .|||...:..::.:  :....||: ...::..:
Zfish    82 WSRREICLLSALVFAAGMCVILG-CMLALKFLXARSQDSQCRQDCV--KRRSLLRA-ARFVQGNI 142

  Fly    63 NFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILD--ISYTLMD-VTEQLLTRTKLAEALNVSA 124
            :.||.||.|||.||||.|.          ||..|.:  :||.::. :.||  .:.||...|....
Zfish   143 DPSVQPCHDFYSFACGGWL----------RRHGIPEDKLSYGIITAIGEQ--NQDKLQRLLQAPV 195

  Fly   125 ---ELLVAQR----FYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNAS-----SFSWF 177
               ||..|:|    ||.||:..:...|..|.| ...||.|.||        |:.|     ...|.
Zfish   196 QRRELESAERKVKEFYRSCINIKEIDRLGAGP-MTEVIDSCGG--------WDLSGAPPGGAGWD 251

  Fly   178 NMSAHL---------SNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHV--ANTSSRAYQ 231
            :.||.:         ...||.|.           :.:|.|          |..|  .|:|..|.:
Zfish   252 SGSAPIRPDFNEMLYKTQGVYST-----------SVFFSL----------TVSVDDKNSSRNAIR 295

  Fly   232 LNEHRMRGYLKEYNLTKDEIS--------AVIEGVFAFWS---------EALSIEDKF------E 273
            :::..:....:...|.:||.|        |::|.:.:...         |.|.:|.|.      |
Zfish   296 IDQEGLTLPERTLYLGQDEDSVKILASYKALMERLLSMLGAHNATLKSREILDLETKLANITVSE 360

  Fly   274 SDRDKCDL--------LSEIEEVPRFGQWRSYYEIAWNGIDFYNGSSGGEF----CDFYYVELDK 326
            .:..:.|:        |.:::::.....|:...:..:|.    |.|...|.    .|:.....|.
Zfish   361 YEDQRKDISSMYNRITLKQLQKMAPSFHWKRLLDRIFND----NFSEEEEIVVLATDYMQTVSDI 421

  Fly   327 VCAKHTEAVANYLAMRFLYRMDDKLKE---------------PKQPEDQKVNCLMIVQMTLPNLF 376
            :.......:.||:..|.:..:.:.|..               .:|..|.:..||...........
Zfish   422 IKTTSKRVLHNYMLWRMVAALSEHLSTAFRSTIHEFSREIDGTEQQLDLERLCLTQANKHFGMAL 486

  Fly   377 NRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEEL 441
            ..|::.:||:....:::.::|.:::.:....|:.::|:|.||:..|..|...:..:.| |.:..|
Zfish   487 GALFVQQHFSSSSRAKVQELVEDIKHSLDVRLQELDWMDEETKDAARGKLQHMMVMTG-YPDFLL 550

  Fly   442 SDTLIREINNLTIVEGSYAQSLI-----NLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQVNA 501
            ...||.|.....:.|.:|.::::     |:::....:|:       |:.|.|   .||....:||
Zfish   551 KPELIDEEYAFDVNEKTYFKNILNSIKYNIKLSIKKIHK-------EVDKTT---WLLPPQALNA 605

  Fly   502 FYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSR 566
            :|....|.:...||:|.|..|...:|.||.:|.||.:||||||||:|..|..:|..|.::.||:.
Zfish   606 YYLPNKNQMVFPAGILQPTLYDPEFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRYGNLKQWWTE 670

  Fly   567 KSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGAD 631
            :|...||::.:|.|..::.:.:  .||.:.|..|..|||||.|||:.:   |..:.|.::..|.:
Zfish   671 ESYRKFQKKTECIVKLYDNFTV--YNQRVNGRLTLGENIADLGGLKLS---YHAYQKWVREHGPE 730

  Fly   632 GETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEH-YWEELTGAHTVDKYRVLGAVSNNDDF 695
                    ..:|||..:.|||||:.|||.||.....:. |.:.||..|..:.|||:|:||..::|
Zfish   731 --------RPLPGLKHTHEQLFFIAFAQNWCMKRRSQSIYLQLLTDKHAPEHYRVIGSVSQFEEF 787

  Fly   696 AEVYKCPLGSPMHPKAESCRMW 717
            ..|:.||.||||:| ...|.:|
Zfish   788 GRVFHCPRGSPMNP-VNKCSVW 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	189/738 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	187/730 (26%)
LOC100332538	XP_021322193.1	M13	146..806	CDD:189000	187/730 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850