DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and Hsp89.1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001319498.1	Gene:	Hsp89.1 / 819968	AraportID:	AT3G07770	Length:	799	Species:	Arabidopsis thaliana

Alignment Length:	706	Identity:	315/706 - (44%)
Similarity:	459/706 - (65%)	Gaps:	30/706 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 AKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIRIK 136
            |:||.:|.||:|:|.||:||||.|||:||||||||||||:||:|.|:::|.:..:..|:|.|||.
plant    94 AEKFEYQAEVSRLMDLIVNSLYSNKEVFLRELISNASDALDKLRYLSVTNPELSKDAPDLDIRIY 158

  Fly   137 ADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGFYS 201
            |||||..:.:.|||||||.|:|::.|||||:||||.|:..::| ||..|.| |::||||||||||
plant   159 ADKENGIITLTDSGIGMTRQELVDCLGTIAQSGTAKFMKALKD-SKDAGGD-NNLIGQFGVGFYS 221

  Fly   202 AFLVADRVVVTTKH-NDDKQYIWESDAN--SFSITEDPRGDTL-KRGSVISLYLKEEAQDFLEED 262
            ||||||||:|:||. ..||||:||.:||  ||:|.||....:| .||:.|:|:||:||::|.:.:
plant   222 AFLVADRVIVSTKSPKSDKQYVWEGEANSSSFTIQEDTDPQSLIPRGTRITLHLKQEAKNFADPE 286

  Fly   263 TVRELIRKYSQFINFPIRMWSSKTVEEEVPVEEEAKPEKSEDDVEDEDAKVEEAEDEKPKTKKVS 327
            .:::|::.||||::|||..|..|...:||.||:: ..|..:||.:|:..|       |.|||||.
plant   287 RIQKLVKNYSQFVSFPIYTWQEKGYTKEVEVEDD-PTETKKDDQDDQTEK-------KKKTKKVV 343

  Fly   328 KTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLLYVPKV 392
            :..|||.|.|:::|||.|.|.|||..||..||:....:..:||..:||..||||.|:|:||||.|
plant   344 ERYWDWELTNETQPIWLRNPKEVTTAEYNEFYRKAFNEYLDPLASSHFTTEGEVEFRSILYVPPV 408

  Fly   393 QPSESFNRYGTKSDNIKLYVRRVFITDEFN-DMMPNYLSFIRGVVDSDDLPLNVSRETLQQHKLI 456
            .||...:....|:.||:|||:||||:|:|: ::.|.||||::|||||.|||||||||.||:.:::
plant   409 SPSGKDDIVNQKTKNIRLYVKRVFISDDFDGELFPRYLSFVKGVVDSHDLPLNVSREILQESRIV 473

  Fly   457 KVIKKKLVRKVLDMLKKI----DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTSNGKG 517
            :::||:||||..||:..|    ::|.|||||..|..::|||.:||..|..|:|.||||.:|..:.
plant   474 RIMKKRLVRKAFDMILGISLSENREDYEKFWDNFGKHLKLGCIEDRENHKRIAPLLRFFSSQSEN 538

  Fly   518 -VTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISALPEFD 581
             :.||.||.|.||.:|:.||:||..:....:.:||:|::|.||.|||||||.:||..:.:|..:.
plant   539 DMISLDEYVENMKPEQKAIYFIASDSITSAKNAPFLEKMLEKGLEVLYLVEPIDEVAVQSLKAYK 603

  Fly   582 GKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCALVA 646
            .|.|.:::||...|.:..:.|:  .::|..|.....|:.. .|.|:::..|:|.|||:|||.||:
plant   604 EKDFVDISKEDLDLGDKNEEKE--AAVKKEFGQTCDWIKK-RLGDKVASVQISNRLSSSPCVLVS 665

  Fly   647 GVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTAKDMA 711
            |.|||:.|||||..:   |.:.|.....|:..::..||||.|.:::.:.....::..|:.|....
plant   666 GKFGWSANMERLMKA---QSTGDTISLDYMKGRRVFEINPDHSIIKNINAAYNSNPNDEDAMRAI 727

  Fly   712 VMMFRTATLRSGYMLQETSQFADSIEQMMRQTL-GVSQDEQVEFDEEE---EDDAE 763
            .:|:..|.:.||:.....::....|.:||...| |.....:|:..:::   ..|||
plant   728 DLMYDAALVSSGFTPDNPAELGGKIYEMMDVALSGKWSSPEVQPQQQQMAHSHDAE 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	309/681 (45%)
		HATPase_c	97..216	CDD:238030	74/119 (62%)
		HSP90	257..748	CDD:278607	199/497 (40%)
Hsp89.1	NP_001319498.1	PRK05218	95..756	CDD:235366	306/676 (45%)
		HATPase_c	122..276	CDD:280651	90/155 (58%)
		HSP90	282..768	CDD:278607	199/499 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780