Protein Alignment Gp93 and hsp90aa1.2

DIOPT Version :10

• Sequence 1: NP_651601.1
• Gene: Gp93 / 43354
• FlyBaseID: FBgn0039562
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001072765.1
• Gene: hsp90aa1.2 / 780222
• XenbaseID: XB-GENE-920475
• Length: 714
• Species: Xenopus tropicalis
• Alignment Length: 737
• Identity: 326/737 - (44%)
• Similarity: 479/737 - (64%)
• Gaps: 41/737 - (5%)

  Fly    68 IREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELH 132
            :.::.:.|.||.|:.::|.||||:.|.||||||||:|||:|||:||||..:|::..:|::..||.
 Frog     1 MEDEVETFAFQAEIAQLMSLIINTFYSNKEIFLREIISNSSDALDKIRYESLTDPSKLDSGKELK 65

  Fly   133 IRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGV 197
            |.:..::.::.|.|:|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||
 Frog    66 IDLIPNRRDRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGV 124

  Fly   198 GFYSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEE 261
            |||||:|||::|.|.|||:||:||.|||.| .||::..| ..:.|.||:.:.|:|||:..::|||
 Frog   125 GFYSAYLVAEKVTVITKHSDDEQYAWESSAGGSFTVRAD-NTEPLGRGTKVILHLKEDQTEYLEE 188

  Fly   262 DTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEE------EAKPEKSE----DDV---EDEDAKV 313
            ..::|:::::||||.:||.::..|..::|:..:|      |.|.||.:    :||   |:||||
 Frog   189 RRIKEIVKRHSQFIGYPITLYMEKERDKEISDDESEEQIDEKKDEKKDKTEIEDVGSDEEEDAK- 252

  Fly   314 EEAEDEKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAE 378
              ..|:|.||||:.:...|...:|.:||||||.|.::|.:||..||||||.|..:.|...||..|
 Frog   253 --KGDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSIE 315

  Fly   379 GEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPL 443
            |::.|::||:||:..|.:.|.. ..|.:|||||||||||.|...:::|.||:.|:|||||:||||
 Frog   316 GQLEFRALLFVPRRAPFDLFES-KKKKNNIKLYVRRVFIMDNCEELIPEYLNIIKGVVDSEDLPL 379

  Fly   444 NVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAK 506
            |:|||.|||.|::|||:|.||:|.|::..::  |||.|:|.:::||.|||||:.||..||.:|::
 Frog   380 NISREMLQQSKILKVIRKNLVKKCLELFTELSEDKENYKKLYEQFSKNIKLGIHEDSQNRKKLSE 444

  Fly   507 LLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVD 570
            |||:.:| :|..:.||:||..|||..|:|||||.|..:.:|..|.|||.|...|.||:|:.|.:|
 Frog   445 LLRYYSSASGDEMISLSEYVSRMKENQKHIYYITGETKDQVSHSAFVEGLRKHGLEVIYMTEPID 509

  Fly   571 EYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSE 635
            |||:..|.|||||...:|.|||.:|.|.|:.||..|..|:.||.|.|.:.:: |..::.|..:|.
 Frog   510 EYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKVIKEI-LDKKVEKVLLSN 573

  Fly   636 RLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEA 700
            ||..|||.:|...:||:.||||:..:.|.:   |.....|:..||.||||..||::..|.::.||
 Frog   574 RLVESPCCIVTSTYGWSANMERIMKAQALR---DNSTMGYMAAKKHLEINCDHPIIETLRQKAEA 635

  Fly   701 DEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEET 765
            |:.|.:.||:..::|.||.|.||:.|.:....::.|.:|::..||:.:|   .|.||||..|
 Frog   636 DKNDKSVKDLVNLLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDED---SFAEEEESPA--- 694

  Fly   766 ATGSQESGNADDEEEEQQHDEL 787
               .|:....:.:|:..:.:|:
 Frog   695 ---IQDMPPLEGDEDASRMEEV 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	HATPase_Hsp90-like	82..275	CDD:340404	99/193 (51%)
		HSP90	257..748	CDD:459703	219/506 (43%)
hsp90aa1.2	NP_001072765.1	HSP90	6..714	CDD:481033	326/732 (45%)