DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and HSP90B1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_003290.1	Gene:	HSP90B1 / 7184	HGNCID:	12028	Length:	803	Species:	Homo sapiens

Alignment Length:	808	Identity:	489/808 - (60%)
Similarity:	619/808 - (76%)	Gaps:	26/808 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYFLLVGL-LLLAGINQIAADDEAATTETIDLDLGSFKEGSRTDAETLKREEEAIQLDGLNVAQ 64
            |:...::|| .:|.....:.||||.....|::.|||..:||||||.|.::||||||||||||.:|
Human     1 MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQ 65

  Fly    65 LKEIREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNP 129
            ::|:|||::||.||.||||||||||||||:||||||||||||||||:|||||::|::...|..|.
Human    66 IRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNE 130

  Fly   130 ELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQ 194
            ||.::||.|||...||:.|:|:|||.::|:.||||||||||::||.||.: ::.:|...:::|||
Human   131 ELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE-AQEDGQSTSELIGQ 194

  Fly   195 FGVGFYSAFLVADRVVVTTKHNDDKQYIWESDANSFSITEDPRGDTLKRGSVISLYLKEEAQDFL 259
            |||||||||||||:|:||:|||:|.|:|||||:|.||:..||||:||.||:.|:|.|||||.|:|
Human   195 FGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYL 259

  Fly   260 EEDTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEEE--AKPEKSEDDVEDEDAKVEEAEDEKPK 322
            |.||::.|::||||||||||.:|||||...|.|:|||  ||.||.|.|  ||.|..||.|::|||
Human   260 ELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESD--DEAAVEEEEEEKKPK 322

  Fly   323 TKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLL 387
            ||||.||.|||.|:||.||||.|...||.||||.:||||.:|:|.:|:...||.|||||||||:|
Human   323 TKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSIL 387

  Fly   388 YVPKVQPSESFNRYGT-KSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRETLQ 451
            :||...|...|:.||: |||.||||||||||||:|:||||.||:|::||||||||||||||||||
Human   388 FVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQ 452

  Fly   452 QHKLIKVIKKKLVRKVLDMLKKIDKEAY-EKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTS-N 514
            ||||:|||:||||||.|||:|||..:.| :.|||||.|||||||:||.|||:|||||||||:| :
Human   453 QHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHH 517

  Fly   515 GKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISALPE 579
            ...:|||.:|.||||.||:.||::||::|.|.|.||||||||.|||||:||.|.||||||.||||
Human   518 PTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPE 582

  Fly   580 FDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCAL 644
            ||||:||||||||.:.:||||:|::.|:::..||||:.|:.|.||||:|.||.||:||:.|||||
Human   583 FDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCAL 647

  Fly   645 VAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTAKD 709
            ||..:||:|||||:..:.|:|...|....||.:||||.||||||||:|::|||::.||.|.|..|
Human   648 VASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLD 712

  Fly   710 MAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEETATGSQESGN 774
            :||::|.||||||||:|.:|..:.|.||:|:|.:|.:..|.:||  ||.|::.||||..:.|...
Human   713 LAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVE--EEPEEEPEETAEDTTEDTE 775

  Fly   775 AD---------DEEEE------QQHDEL 787
            .|         |||||      .:.|||
Human   776 QDEDEEMDVGTDEEEETAKESTAEKDEL 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	432/675 (64%)
		HATPase_c	97..216	CDD:238030	72/118 (61%)
		HSP90	257..748	CDD:278607	314/495 (63%)
HSP90B1	NP_003290.1	HSP90	77..>464	CDD:332554	255/389 (66%)
		HSP90	257..755	CDD:306652	315/499 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..323		19/36 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..803		18/54 (33%)
		Prevents secretion from ER	800..803		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147261
Domainoid	1	1.000	643	1.000	Domainoid score	I162
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2476
Inparanoid	1	1.050	962	1.000	Inparanoid score	I329
Isobase	1	0.950	-	0	Normalized mean entropy	S665
OMA	1	1.010	-	-		QHG54632
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		oto90085
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3083
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750