DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and hsp90aa1.2

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001038538.1	Gene:	hsp90aa1.2 / 565155	ZFINID:	ZDB-GENE-031001-3	Length:	734	Species:	Danio rerio

Alignment Length:	741	Identity:	330/741 - (44%)
Similarity:	478/741 - (64%)	Gaps:	49/741 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134
            |:.:.|.||.|:.::|.||||:.|.||||||||||||:|||:||||..:|::..:|::..:|.|.
Zfish    13 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKDLKIE 77

  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199
            |..:||.:.|.|:|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||||
Zfish    78 IIPNKEERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 136

  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263
            |||:|||::|.|.|||.||:||.|||.| .||::..| ..:.:.||:.:.|:|||:..:::||..
Zfish   137 YSAYLVAEKVTVITKHLDDEQYAWESSAGGSFTVKVD-NSEPIGRGTKVILHLKEDQTEYIEERR 200

  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEV-----------PVEEEAKPEKSEDDVEDEDAKVEEAE 317
            ::|:::|:||||.:||.::..|..::||           ..|||.:.||.||..|.||...:|.:
Zfish   201 IKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEEKEKEKEEEEEGEKDEDKPEIEDVGSDEDD 265

  Fly   318 --------DEKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTH 374
                    |:|.|.||:.:...|...:|.:||:|||.|.::|.:||..||||||.|..:.|...|
Zfish   266 HDHGDKCGDKKKKKKKIKEKYIDQEELNKTKPLWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKH 330

  Fly   375 FIAEGEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSD 439
            |..||::.|::||:||:..|.:.|.. ..|.:|||||||||||.|..::::|.||:||:|||||:
Zfish   331 FSVEGQLEFRALLFVPRRAPFDLFEN-KKKKNNIKLYVRRVFIMDNCDELIPEYLNFIKGVVDSE 394

  Fly   440 DLPLNVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRS 502
            |||||:|||.|||.|::|||:|.||:|.|::..::  ||:.|:|::::||.|||||:.||..||.
Zfish   395 DLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRK 459

  Fly   503 RLAKLLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLV 566
            :|::|||:.|| :|..:.||.:|..|||..|:|||||.|..:.:|..|.|||||...|.||:|::
Zfish   460 KLSELLRYYTSASGDEMVSLKDYVTRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMI 524

  Fly   567 EAVDEYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKA 631
            |.:||||:..|.||:||...:|.|||.:|.|.|:.||..|..||.||.|.|.:.|: |:.::.|.
Zfish   525 EPIDEYCVQQLKEFEGKNLVSVTKEGLELPEDEEEKKKQEEKKSKFENLCKIMKDI-LEKKVEKV 588

  Fly   632 QVSERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLR 696
            .||.||.:|||.:|...:|||.||||:..:.|.:   |.....|:..||.|||||.||::..|.:
Zfish   589 TVSNRLVSSPCCIVTSTYGWTANMERIMKAQALR---DNSTMGYMAAKKHLEINPDHPIVETLRQ 650

  Fly   697 RVEADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDD 761
            :.|||:.|.:.||:.:::|.||.|.||:.|.:....::.|.:|::..||:.:|:.         .
Zfish   651 KAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGIDEDDL---------S 706

  Fly   762 AEETATGSQE-----SGNADDEEEEQ 782
            |||.::...|     .|:.|....|:
Zfish   707 AEEPSSAPIEEMPPLEGDDDTSRMEE 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	319/693 (46%)
		HATPase_c	97..216	CDD:238030	69/118 (58%)
		HSP90	257..748	CDD:278607	222/512 (43%)
hsp90aa1.2	NP_001038538.1	PTZ00272	16..734	CDD:240341	329/738 (45%)
		HATPase_c	38..189	CDD:214643	86/157 (55%)
		HSP90	194..724	CDD:278607	227/543 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720