Protein Alignment Gp93 and Hsp83

DIOPT Version :10

• Sequence 1: NP_651601.1
• Gene: Gp93 / 43354
• FlyBaseID: FBgn0039562
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_523899.1
• Gene: Hsp83 / 38389
• FlyBaseID: FBgn0001233
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 741
• Identity: 334/741 - (45%)
• Similarity: 486/741 - (65%)
• Gaps: 50/741 - (6%)

  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134
            |:|:.|.||.|:.::|.||||:.|.||||||||||||||||:||||..:|::..:|::..||:|:
  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67

  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199
            :..:|....|.|:|:|||||..||:|||||||||||..|:..:|     .|.|:: |||||||||
  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 126

  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263
            |||:||||:|.||:|:|||:||:|||.| .||::..| ..:.|.||:.|.||:||:..|:|||..
  Fly   127 YSAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESK 190

  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEVPVEEEAKPEKSEDDV---------------EDEDAKV 313
            ::|::.|:||||.:||::...|..|:||. ::||..||.|.|.               |||||..
  Fly   191 IKEIVNKHSQFIGYPIKLLVEKEREKEVS-DDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADK 254

  Fly   314 EEAEDEKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAE 378
            ::.:.:|.||.| .|.|.|..| |.:||||||.|.:::::||..||||||.|..:.|...||..|
  Fly   255 KDKDAKKKKTIK-EKYTEDEEL-NKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVE 317

  Fly   379 GEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPL 443
            |::.|::||::|:..|.:.|... .|.:|||||||||||.|...|::|.||:|::|||||:||||
  Fly   318 GQLEFRALLFIPRRTPFDLFENQ-KKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPL 381

  Fly   444 NVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAK 506
            |:|||.|||:|::|||:|.||:|.:::::::  |||.|:||:.:||.|:||||.||.:||::||.
  Fly   382 NISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLAD 446

  Fly   507 LLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVD 570
            .|||.|| :|....|||:|..|||..|:|:|:|.|.::.:|..|.||||:.::|:||:|:.|.:|
  Fly   447 FLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPID 511

  Fly   571 EYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSE 635
            ||.|..|.|:.||:..:|.|||.:|.|.|..||..|..|:.||.|.|.:..: |.:::.|..||.
  Fly   512 EYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSI-LDNKVEKVVVSN 575

  Fly   636 RLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEA 700
            ||.:|||.:|...|||:.||||:..:.|.:   |.....|:..||.|||||.||::..|.::.:|
  Fly   576 RLVDSPCCIVTSQFGWSANMERIMKAQALR---DTATMGYMAGKKQLEINPDHPIVETLRQKADA 637

  Fly   701 DEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEET 765
            |:.|...||:.:::|.|:.|.||:.|......|..|.:|::..||:.:||.:..|:
  Fly   638 DKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDD--------- 693

  Fly   766 ATGSQESGNA----DDEEEEQQHDEL 787
               :|.:|:|    :|.|:....:|:
  Fly   694 ---AQSAGDAPSLVEDTEDASHMEEV 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	HATPase_Hsp90-like	82..275	CDD:340404	105/193 (54%)
		HSP90	257..748	CDD:459703	222/508 (44%)
Hsp83	NP_523899.1	HSP90	6..717	CDD:481033	332/738 (45%)