DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and Hsp90b1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001012197.2	Gene:	Hsp90b1 / 362862	RGDID:	1310482	Length:	804	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	483/799 - (60%)
Similarity:	620/799 - (77%)	Gaps:	16/799 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYFLLVGL---LLLAGINQIAADDEAATTETIDLDLGSFKEGSRTDAETLKREEEAIQLDGLNV 62
            |:...::||   ||..|.  :.||||.....|::.|||..:||||||.|.::||||||||||||.
  Rat     1 MRVLWVLGLCCVLLTFGF--VRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNA 63

  Fly    63 AQLKEIREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELET 127
            :|::|:|||::||.||.||||||||||||||:||||||||||||||||:|||||::|::...|..
  Rat    64 SQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAG 128

  Fly   128 NPELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMI 192
            |.||.::||.|:|...||:.|:|:|||.::|:.||||||||||::||.||.: ::.:|...:::|
  Rat   129 NEELTVKIKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE-AQEDGQSTSELI 192

  Fly   193 GQFGVGFYSAFLVADRVVVTTKHNDDKQYIWESDANSFSITEDPRGDTLKRGSVISLYLKEEAQD 257
            |||||||||||||||:|:||:|||:|.|:|||||:|.||:..||||:||.||:.|:|.|||||.|
  Rat   193 GQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASD 257

  Fly   258 FLEEDTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEEEAKPEKSEDDVEDEDAKVEEAEDEKPK 322
            :||.||::.|:|||||||||||.:|||||...|.|:||:...::.:::.:||.|..||.|::|||
  Rat   258 YLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEADDEAAVEEEEEEKKPK 322

  Fly   323 TKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLL 387
            ||||.||.|||.|:||.||||.|...||.||||.:||||.:|:|.:|:...||.|||||||||:|
  Rat   323 TKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSIL 387

  Fly   388 YVPKVQPSESFNRYGT-KSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRETLQ 451
            :||...|...|:.||: |||.||||||||||||:|:||||.||:|::||||||||||||||||||
  Rat   388 FVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQ 452

  Fly   452 QHKLIKVIKKKLVRKVLDMLKKIDKEAY-EKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTS-N 514
            ||||:|||:||||||.|||:|||..|.| :.|||||.|||||||:||.|||:|||||||||:| :
  Rat   453 QHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHH 517

  Fly   515 GKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISALPE 579
            ...:|||.:|.||||.||:.||::||::|.|.|.||||||||.|||||:||.|.||||||.||||
  Rat   518 STDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPE 582

  Fly   580 FDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCAL 644
            ||||:||||||||.:.:||||||::.|:.:..||||:.|:.|.||||:|.||.||:||:.|||||
  Rat   583 FDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCAL 647

  Fly   645 VAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTAKD 709
            ||..:||:|||||:..:.|:|...|....||.:||||.||||||||:|::||||:.||.|.|..|
  Rat   648 VASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVMD 712

  Fly   710 MAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEF--DEEEEDDAEETATGSQE- 771
            :||::|.||||||||:|.:|..:.|.||:|:|.:|.:..:.|||.  :||.||..|:|...|::
  Rat   713 LAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTTEDTTDDSEQD 777

  Fly   772 ----SGNADDEEEEQQHDE 786
                ...|::|||||:.::
  Rat   778 EEETDAGAEEEEEEQETEK 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	428/673 (64%)
		HATPase_c	97..216	CDD:238030	71/118 (60%)
		HSP90	257..748	CDD:278607	311/493 (63%)
Hsp90b1	NP_001012197.2	HATPase_Hsp90-like	83..275	CDD:340404	123/192 (64%)
		HSP90	257..755	CDD:395131	311/497 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..323		12/34 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..804		16/48 (33%)
		Prevents secretion from ER. /evidence=ECO:0000255	801..804
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340912
Domainoid	1	1.000	644	1.000	Domainoid score	I154
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2476
Inparanoid	1	1.050	964	1.000	Inparanoid score	I309
OMA	1	1.010	-	-		QHG54632
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		oto97203
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770