DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and HSP90AA1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001017963.2	Gene:	HSP90AA1 / 3320	HGNCID:	5253	Length:	854	Species:	Homo sapiens

Alignment Length:	734	Identity:	336/734 - (45%)
Similarity:	479/734 - (65%)	Gaps:	39/734 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134
            |:.:.|.||.|:.::|.||||:.|.||||||||||||:|||:||||..:|::..:|::..||||.
Human   137 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHIN 201

  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199
            :..:|:::.|.|:|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||||
Human   202 LIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 260

  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263
            |||:|||::|.|.||||||:||.|||.| .||::..| .|:.:.||:.:.|:|||:..::|||..
Human   261 YSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD-TGEPMGRGTKVILHLKEDQTEYLEERR 324

  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEV----------PVEEEAKPEK-SEDDVEDEDAKVEEAE 317
            ::|:::|:||||.:||.::..|..::||          ..||:.|.|| |||..|.||...:|.|
Human   325 IKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEE 389

  Fly   318 D----EKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAE 378
            :    :|.|.||:.:...|...:|.:||||||.|.::|.:||..||||||.|..:.|...||..|
Human   390 EKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVE 454

  Fly   379 GEVTFKSLLYVPKVQPSESF-NRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLP 442
            |::.|::||:||:..|.:.| ||  .|.:|||||||||||.|...:::|.||:||||||||:|||
Human   455 GQLEFRALLFVPRRAPFDLFENR--KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLP 517

  Fly   443 LNVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLA 505
            ||:|||.|||.|::|||:|.||:|.|::..::  |||.|:||:::||.|||||:.||..||.:|:
Human   518 LNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLS 582

  Fly   506 KLLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAV 569
            :|||:.|| :|..:.||.:|..|||..|:|||||.|..:.:|..|.|||||...|.||:|::|.:
Human   583 ELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPI 647

  Fly   570 DEYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVS 634
            ||||:..|.||:||...:|.|||.:|.|.|:.||..|..|:.||.|.|.:.|: |:.::.|..||
Human   648 DEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDI-LEKKVEKVVVS 711

  Fly   635 ERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVE 699
            .||..|||.:|...:|||.||||:..:.|.:   |.....|:..||.|||||.|.::..|.::.|
Human   712 NRLVTSPCCIVTSTYGWTANMERIMKAQALR---DNSTMGYMAAKKHLEINPDHSIIETLRQKAE 773

  Fly   700 ADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEE 764
            ||:.|.:.||:.::::.||.|.||:.|::....|:.|.:|::..||:.:|:..      .||...
Human   774 ADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPT------ADDTSA 832

  Fly   765 TATGSQESGNADDEEEEQQ 783
            ..|........||:....:
Human   833 AVTEEMPPLEGDDDTSRME 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	327/690 (47%)
		HATPase_c	97..216	CDD:238030	69/118 (58%)
		HSP90	257..748	CDD:278607	228/509 (45%)
HSP90AA1	NP_001017963.2	PTZ00272	140..854	CDD:240341	335/731 (46%)
		HATPase_c	162..313	CDD:214643	88/157 (56%)
		HSP90	318..844	CDD:278607	232/537 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720