DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and hsp90aa1.1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_571403.1	Gene:	hsp90aa1.1 / 30591	ZFINID:	ZDB-GENE-990415-94	Length:	726	Species:	Danio rerio

Alignment Length:	710	Identity:	330/710 - (46%)
Similarity:	470/710 - (66%)	Gaps:	29/710 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134
            |:.:.|.||.|:.::|.||||:.|.||||||||||||:|||:||||..:|::..:|::..:|.|.
Zfish    13 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKDLKIE 77

  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199
            :..|::.:.|.|:|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||||
Zfish    78 LIPDQKERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 136

  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263
            |||:|||::|.|.||||||:||||||.| .||::..| .|:::.||:.:.|:|||:..:::||..
Zfish   137 YSAYLVAEKVTVITKHNDDEQYIWESAAGGSFTVKPD-FGESIGRGTKVILHLKEDQSEYVEEKR 200

  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEVPVEEEAKPEKSE-------DDVEDEDAKVEEAEDEK- 320
            ::|:::|:||||.:||.::..|..|:||.:||..|.|:.|       |..:.||...:|.||.|
Zfish   201 IKEVVKKHSQFIGYPITLYIEKQREKEVDLEEGEKQEEEEVAAGEDKDKPKIEDLGADEDEDSKD 265

  Fly   321 ---PKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVT 382
               .:.|||.:...|...:|.:||||||.|.::|.:||..|||||:.|..:.|...||..||::.
Zfish   266 GKNKRKKKVKEKYIDAQELNKTKPIWTRNPDDITNEEYGEFYKSLSNDWEDHLAVKHFSVEGQLE 330

  Fly   383 FKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSR 447
            |::||:||:....:.|.. ..|.:|||||||||||.|...:::|.||:||:|||||:|||||:||
Zfish   331 FRALLFVPRRAAFDLFEN-KKKRNNIKLYVRRVFIMDNCEELIPEYLNFIKGVVDSEDLPLNISR 394

  Fly   448 ETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAKLLRF 510
            |.|||.|::|||:|.||:|.||:..::  ||:.|:|::::||.|||||:.||..||.:|:.|||:
Zfish   395 EMLQQSKILKVIRKNLVKKCLDLFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRKKLSDLLRY 459

  Fly   511 QTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCI 574
            .|| :|..:.||.:|..|||..|:|||||.|..:.:|..|.|||||...|.||:|::|.:||||:
Zfish   460 YTSASGDEMVSLKDYVSRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCV 524

  Fly   575 SALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSN 639
            ..|.|:|||...:|.|||.:|.|.|:.||..:.||:.:|.|.|.:.|: |..:|.|..||.||.:
Zfish   525 QQLKEYDGKNLVSVTKEGLELPEDEEEKKKQDELKAKYENLCKIMKDI-LDKKIEKVTVSNRLVS 588

  Fly   640 SPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEAD 704
            |||.:|...:|||.||||:..|.|.:   |.....|:..||.|||||.||::..|..:.||::.|
Zfish   589 SPCCIVTSTYGWTANMERIMKSQALR---DNSTMGYMTAKKHLEINPAHPIVETLREKAEAEKND 650

  Fly   705 DTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEE 764
            ...||:.:::|.||.|.||:.|.:....|:.|.:|::..||:..|:.|.  ||....|||
Zfish   651 KAVKDLVILLFETALLSSGFTLDDPQTHANRIYRMIKLGLGIDDDDSVV--EEISQPAEE 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	320/685 (47%)
		HATPase_c	97..216	CDD:238030	67/118 (57%)
		HSP90	257..748	CDD:278607	222/504 (44%)
hsp90aa1.1	NP_571403.1	PTZ00272	16..726	CDD:240341	329/707 (47%)
		HATPase_c	38..189	CDD:214643	87/157 (55%)
		HSP90	194..716	CDD:278607	229/522 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..274		13/44 (30%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:P07900	676..726		12/35 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..726		6/13 (46%)
		TPR repeat-binding. /evidence=ECO:0000250\|UniProtKB:P07900	717..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820