DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and Hsp90ab1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001004082.3	Gene:	Hsp90ab1 / 301252	RGDID:	1303075	Length:	724	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	337/733 - (45%)
Similarity:	485/733 - (66%)	Gaps:	43/733 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134
            |:.:.|.||.|:.::|.||||:.|.||||||||||||||||:||||..:|::..:|::..||.|.
  Rat    10 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKID 74

  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199
            |..:.:.:.|.::|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||||
  Rat    75 IIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 133

  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263
            |||:|||::|||.||||||:||.|||.| .||::..| .|:.:.||:.:.|:|||:..::|||..
  Rat   134 YSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRAD-HGEPIGRGTKVILHLKEDQTEYLEERR 197

  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEVPVE--EEAKPEKSEDDVEDED-AKVEE---------A 316
            |:|:::|:||||.:||.::..|..|:|:..:  ||.|.||.|:|.|||: .|:|:         .
  Rat   198 VKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKEDEEKPKIEDVGSDEEDDSG 262

  Fly   317 EDEKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEV 381
            :|:|.||||:.:...|...:|.:||||||.|.::|::||..||||||.|..:.|...||..||::
  Rat   263 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQL 327

  Fly   382 TFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVS 446
            .|::||::|:..|.:.|.. ..|.:|||||||||||.|..::::|.||:||||||||:|||||:|
  Rat   328 EFRALLFIPRRAPFDLFEN-KKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNIS 391

  Fly   447 RETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAKLLR 509
            ||.|||.|::|||:|.:|:|.|::..::  |||.|:||::.||.|:|||:.||.:||.||::|||
  Rat   392 REMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLR 456

  Fly   510 FQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYC 573
            :.|| :|..:|||:||..|||..|:.||||.|.::.:|..|.||||:..:|:||:|:.|.:||||
  Rat   457 YHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYC 521

  Fly   574 ISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLS 638
            :..|.|||||...:|.|||.:|.|.|:.||..|..|:.||.|.|.:.:: |..::.|..:|.||.
  Rat   522 VQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEI-LDKKVEKVTISNRLV 585

  Fly   639 NSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEA 703
            :|||.:|...:|||.||||:..:.|.:   |.....|:..||.|||||.||::..|.::.|||:.
  Rat   586 SSPCCIVTSTYGWTANMERIMKAQALR---DNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKN 647

  Fly   704 DDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEETATG 768
            |...||:.|::|.||.|.||:.|::....::.|.:|::..||:.:||               .|.
  Rat   648 DKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDE---------------VTA 697

  Fly   769 SQESGNADDEEEEQQHDE 786
            .:.|....||....:.||
  Rat   698 EEPSAAVPDEIPPLEGDE 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	326/686 (48%)
		HATPase_c	97..216	CDD:238030	69/118 (58%)
		HSP90	257..748	CDD:278607	227/505 (45%)
Hsp90ab1	NP_001004082.3	Interaction with TP53. /evidence=ECO:0000250\|UniProtKB:P08238	2..527		262/524 (50%)
		Interaction with BIRC2. /evidence=ECO:0000250\|UniProtKB:P08238	2..214		113/210 (54%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:P11499	9..231		117/227 (52%)
		HSP90	14..724	CDD:332554	336/729 (46%)
		Interaction with AHSA1. /evidence=ECO:0000250\|UniProtKB:P08238	215..552		161/337 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..270		17/47 (36%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:P11499	264..608		169/345 (49%)
		Interaction with NR1D1. /evidence=ECO:0000250\|UniProtKB:P11499	620..723		36/111 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..724		7/37 (19%)
		TPR repeat-binding	720..724
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720