DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gp93 and Trap1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001034090.1	Gene:	Trap1 / 287069	RGDID:	1359733	Length:	706	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	216/715 - (30%)
Similarity:	368/715 - (51%)	Gaps:	127/715 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TDAETLKREEEAIQLDGLNVAQLKEIREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNA 107
            |.|...|:||....:    ::..:.::....|..||.|..:::.::..|||..||:|:|||||||
  Rat    62 TQAAEDKKEEALHSI----ISNTEAVQGSVSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA 122

  Fly   108 SDAIDKIRLLALSNSKELETNPELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTAD 172
            |||::|:|...:...:.|   ||:.|.::.|.|...:.|.|:|||||.::|::||||||:||:..
  Rat   123 SDALEKLRHKRVCEGQVL---PEMEIHLQTDAEKGTITIQDTGIGMTKEELVSNLGTIARSGSKA 184

  Fly   173 FLAKMQDPSKSEGLDMNDMIGQFGVGFYSAFLVADRVVVTTK--HNDDKQYIWESDANS-FSITE 234
            ||..:|..:::.    :.:||||||||||||:|||:|.|.::  ..:...|.|.||.:. |.|.|
  Rat   185 FLEALQHQAETS----SRIIGQFGVGFYSAFMVADKVEVYSRPAAPESPGYQWLSDGSGVFEIAE 245

  Fly   235 DPRGDTLKRGSVISLYLKEEAQDFLEEDTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEEEAKP 299
               ...::.|:.|.::||.:.:||..|..|::::.|||.|::||:.:...:
  Rat   246 ---ASGVRPGTKIIIHLKSDCKDFANESRVQDVVTKYSNFVSFPLYLNGRR-------------- 293

  Fly   300 EKSEDDVEDEDAKVEEAEDEKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTK 364
                                                ||..:.||...|.:::|.::..||:.:.:
  Rat   294 ------------------------------------INTLQAIWMMDPKDISEFQHEEFYRYIAQ 322

  Fly   365 DSSEPLTQTHFIAEGEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYL 429
            ...:|....|:..:..:..:|:.|||:::|| .|:.......::.||.|:|.|..:..|::|.:|
  Rat   323 AYDKPRFILHYKTDAPLNIRSIFYVPEMKPS-MFDVSRELGSSVALYSRKVLIQTKATDILPKWL 386

  Fly   430 SFIRGVVDSDDLPLNVSRETLQQHKLIK----VIKKKLVRKVLDMLKKIDKEAYEKFWKEFSTNI 490
            .|:||||||:|:|||:|||.||:..||:    |::::|::..:|..|| |.|.|.||::::...:
  Rat   387 RFVRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKK-DAEKYAKFFEDYGLFM 450

  Fly   491 KLGVM--EDPSNRSRLAKLLRFQTS---NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSP 550
            :.|::  .:...:..:|||||:::|   .|: :|||::|..||:|...:|||:...||...|.||
  Rat   451 REGIVTTAEQDIKEDIAKLLRYESSALPAGQ-LTSLSDYASRMQAGTRNIYYLCAPNRHLAEHSP 514

  Fly   551 FVERLLSKGYEVLYLVEAVDEYCISALPEFDGK-----------------KFQNVAKEGFQLNES 598
            :.|.:..|..|||:..|..||..:..|.|||.|                 ||::.:..|.:|:|.
  Rat   515 YYEAMKQKQTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPAGERLSEK 579

  Fly   599 EKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCALVAGVFGWTGN---MERLAM 660
            |.            |.|:.|:.: ||..:::..:|:.||...|..:.....|...:   |::||.
  Rat   580 ET------------EELMAWMRN-ALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAK 631

  Fly   661 SNAHQKSDDPQRTYYLNQKKTLEINPRHPLMREL--LRRVEADEADDTAKDMAVMMFRTATLRSG 723
            :       ..:|...|  :.||||||||.|:::|  ||..|    .:.|:.:...::..|.:.:|
  Rat   632 T-------QEERAQLL--QPTLEINPRHTLIKKLNQLRERE----PELAQLLVDQIYENAMIAAG 683

Fly 724 723
Rat 684 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	211/684 (31%)
		HATPase_c	97..216	CDD:238030	56/120 (47%)
		HSP90	257..748	CDD:278607	136/498 (27%)
Trap1	NP_001034090.1	PRK05218	89..704	CDD:235366	211/684 (31%)
		HATPase_c	114..223	CDD:238030	55/115 (48%)
		HSP90	265..703	CDD:278607	136/498 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820