DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and hsp90

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_594365.1	Gene:	hsp90 / 2543539	PomBaseID:	SPAC926.04c	Length:	704	Species:	Schizosaccharomyces pombe

Alignment Length:	717	Identity:	339/717 - (47%)
Similarity:	492/717 - (68%)	Gaps:	31/717 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 FTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIRIKADK 139
            |.|:.|::::|.||||::|.||||||||||||||||:||||..:||:...|:...:|.|||..||
pombe     7 FKFEAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQSLSDPHALDAEKDLFIRITPDK 71

  Fly   140 ENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGFYSAFL 204
            |||.|.|.|:|||||..|||||||.||||||..|:     .:.:.|.|:: ||||||||||||:|
pombe    72 ENKILSIRDTGIGMTKNDLINNLGVIAKSGTKQFM-----EAAASGADIS-MIGQFGVGFYSAYL 130

  Fly   205 VADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDTVRELI 268
            |||:|.|.:|||||:||||||.| .||::|.|..|..|.||:.|.|::||:...:|||.|:::.:
pombe   131 VADKVQVVSKHNDDEQYIWESSAGGSFTVTLDTDGPRLLRGTEIRLFMKEDQLQYLEEKTIKDTV 195

  Fly   269 RKYSQFINFPIRMWSSKTVEEEVPVEEEAKPEKSEDDVEDEDAKVEEAEDE----KPKTKKVSKT 329
            :|:|:||::||::..::.||:|||.|||.:..|:|:|  |:..|:||.:||    :.|||||.:|
pombe   196 KKHSEFISYPIQLVVTREVEKEVPEEEETEEVKNEED--DKAPKIEEVDDESEKKEKKTKKVKET 258

  Fly   330 TWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLLYVPKVQP 394
            |.:...:|.:||||||.|:|||::||.|||||||.|..:.|...||..||::.|:::|:||:..|
pombe   259 TTETEELNKTKPIWTRNPSEVTKEEYASFYKSLTNDWEDHLAVKHFSVEGQLEFRAILFVPRRAP 323

  Fly   395 SESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRETLQQHKLIKVI 459
            .:.|.. ..|.:|||||||||||||:..:::|.:|.||:|||||:|||||:|||.|||:|::|||
pombe   324 MDLFEA-KRKKNNIKLYVRRVFITDDCEELIPEWLGFIKGVVDSEDLPLNLSREMLQQNKIMKVI 387

  Fly   460 KKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTSNG-KGVTSL 521
            :|.|||:.|||..:|  |||.::.|:..||.|:|||:.||.:||..||||||:.:.|. ..:.||
pombe   388 RKNLVRRCLDMFNEIAEDKENFKTFYDAFSKNLKLGIHEDAANRPALAKLLRYNSLNSPDDLISL 452

  Fly   522 AEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISALPEFDGKKFQ 586
            .:|..:|...|::||:|.|.::..||.|||:|...:|.::||::|:.:|||.::.|.||:|||..
pombe   453 EDYITKMPEHQKNIYFITGESKQAVENSPFLEIFRAKKFDVLFMVDPIDEYAVTQLKEFEGKKLV 517

  Fly   587 NVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCALVAGVFGW 651
            |:.|:|.:|.|:::.|...|.|:..:|...|.|..: |.|::.|..||.::..|||.|..|.:||
pombe   518 NITKDGLELEETDEEKAAREKLEKEYEEFAKQLKTI-LGDKVEKVVVSNKIVGSPCLLTTGQYGW 581

  Fly   652 TGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADD-TAKDMAVMMF 715
            :.||||:..:.|.:   |...:.|::.:||.||||:.|::.||.::||.:.|:| :.||:|.:::
pombe   582 SANMERIMKAQALR---DTSMSAYMSSRKTFEINPKSPIIAELKKKVEENGAEDRSVKDLATILY 643

  Fly   716 RTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEETATGS-QESGNADDEE 779
            .||.|.||:.|.:.|.:|..|.:::  :||:|      .|||||...||.:|.| ....||:.:.
pombe   644 ETALLSSGFTLDDPSAYAQRINRLI--SLGLS------IDEEEEAPIEEISTESVAAENNAESKM 700

  Fly   780 EE 781
            ||
pombe   701 EE 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	323/678 (48%)
		HATPase_c	97..216	CDD:238030	73/118 (62%)
		HSP90	257..748	CDD:278607	218/498 (44%)
hsp90	NP_594365.1	PTZ00272	4..704	CDD:240341	339/717 (47%)
		HATPase_c	29..161	CDD:238030	86/137 (63%)
		HSP90	185..704	CDD:278607	232/533 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
TreeFam	0	0.000	Not matched by this tool.
	5	4.710