DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp93 and Hsp90b1

DIOPT Version :9

Sequence 1:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_035761.1	Gene:	Hsp90b1 / 22027	MGIID:	98817	Length:	802	Species:	Mus musculus

Alignment Length:	799	Identity:	487/799 - (60%)
Similarity:	619/799 - (77%)	Gaps:	18/799 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYFLLVGL---LLLAGINQIAADDEAATTETIDLDLGSFKEGSRTDAETLKREEEAIQLDGLNV 62
            |:...::||   ||..|.  :.||||.....|::.|||..:||||||.|.::||||||||||||.
Mouse     1 MRVLWVLGLCCVLLTFGF--VRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNA 63

  Fly    63 AQLKEIREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELET 127
            :|::|:|||::||.||.||||||||||||||:||||||||||||||||:|||||::|::...|..
Mouse    64 SQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAG 128

  Fly   128 NPELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMI 192
            |.||.::||.|||...||:.|:|:|||.::|:.||||||||||::||.||.: ::.:|...:::|
Mouse   129 NEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE-AQEDGQSTSELI 192

  Fly   193 GQFGVGFYSAFLVADRVVVTTKHNDDKQYIWESDANSFSITEDPRGDTLKRGSVISLYLKEEAQD 257
            |||||||||||||||:|:||:|||:|.|:|||||:|.||:..||||:||.||:.|:|.|||||.|
Mouse   193 GQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASD 257

  Fly   258 FLEEDTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEEE--AKPEKSEDDVEDEDAKVEEAEDEK 320
            :||.||::.|:|||||||||||.:|||||...|.|:||:  ||.||.|.|  ||.|..||.|::|
Mouse   258 YLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKEESD--DEAAVEEEEEEKK 320

  Fly   321 PKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKS 385
            ||||||.||.|||.|:||.||||.|...||.||||.:||||.:|:|.:|:...||.|||||||||
Mouse   321 PKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKS 385

  Fly   386 LLYVPKVQPSESFNRYGT-KSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRET 449
            :|:||...|...|:.||: |||.||||||||||||:|:||||.||:|::||||||||||||||||
Mouse   386 ILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET 450

  Fly   450 LQQHKLIKVIKKKLVRKVLDMLKKIDKEAY-EKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTS 513
            ||||||:|||:||||||.|||:|||..|.| :.|||||.|||||||:||.|||:|||||||||:|
Mouse   451 LQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSS 515

  Fly   514 -NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISAL 577
             :...:|||.:|.||||.||:.||::||::|.|.|.||||||||.|||||:||.|.||||||.||
Mouse   516 HHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQAL 580

  Fly   578 PEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPC 642
            ||||||:||||||||.:.:||||:|::.|:.:..||||:.|:.|.||||:|.||.||:||:.|||
Mouse   581 PEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPC 645

  Fly   643 ALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTA 707
            ||||..:||:|||||:..:.|:|...|....||.:||||.||||||||:|::|||::.||.|.|.
Mouse   646 ALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTV 710

  Fly   708 KDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEE-----DDAEETAT 767
            .|:||::|.||||||||:|.:|..:.|.||:|:|.:|.:..:.|||.:.|||     :|||::..
Mouse   711 MDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSEDAEDSEQ 775

  Fly   768 GSQESGNADDEEEEQQHDE 786
            ...|..:|..||||::.::
Mouse   776 DEGEEMDAGTEEEEEETEK 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	433/675 (64%)
		HATPase_c	97..216	CDD:238030	72/118 (61%)
		HSP90	257..748	CDD:278607	315/495 (64%)
Hsp90b1	NP_035761.1	PRK05218	74..746	CDD:235366	433/674 (64%)
		HATPase_c	96..254	CDD:214643	98/158 (62%)
		HSP90	257..783	CDD:278607	325/527 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..323		18/34 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..802		15/46 (33%)
		Prevents secretion from ER	799..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837194
Domainoid	1	1.000	645	1.000	Domainoid score	I163
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2476
Inparanoid	1	1.050	963	1.000	Inparanoid score	I326
Isobase	1	0.950	-	0	Normalized mean entropy	S665
OMA	1	1.010	-	-		QHG54632
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		oto93660
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3083
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740