Protein Alignment Gp93 and Hsp90b1

DIOPT Version :10

• Sequence 1: NP_651601.1
• Gene: Gp93 / 43354
• FlyBaseID: FBgn0039562
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_035761.1
• Gene: Hsp90b1 / 22027
• MGIID: 98817
• Length: 802
• Species: Mus musculus
• Alignment Length: 799
• Identity: 487/799 - (60%)
• Similarity: 619/799 - (77%)
• Gaps: 18/799 - (2%)

  Fly     1 MKYFLLVGL---LLLAGINQIAADDEAATTETIDLDLGSFKEGSRTDAETLKREEEAIQLDGLNV 62
            |:...::||   ||..|.  :.||||.....|::.|||..:||||||.|.::||||||||||||.
Mouse     1 MRVLWVLGLCCVLLTFGF--VRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNA 63

  Fly    63 AQLKEIREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELET 127
            :|::|:|||::||.||.||||||||||||||:||||||||||||||||:|||||::|::...|..
Mouse    64 SQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAG 128

  Fly   128 NPELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMI 192
            |.||.::||.|||...||:.|:|:|||.::|:.||||||||||::||.||.: ::.:|...:::|
Mouse   129 NEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE-AQEDGQSTSELI 192

  Fly   193 GQFGVGFYSAFLVADRVVVTTKHNDDKQYIWESDANSFSITEDPRGDTLKRGSVISLYLKEEAQD 257
            |||||||||||||||:|:||:|||:|.|:|||||:|.||:..||||:||.||:.|:|.|||||.|
Mouse   193 GQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASD 257

  Fly   258 FLEEDTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEEE--AKPEKSEDDVEDEDAKVEEAEDEK 320
            :||.||::.|:|||||||||||.:|||||...|.|:||:  ||.||.|.|  ||.|..||.|::|
Mouse   258 YLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKEESD--DEAAVEEEEEEKK 320

  Fly   321 PKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKS 385
            ||||||.||.|||.|:||.||||.|...||.||||.:||||.:|:|.:|:...||.|||||||||
Mouse   321 PKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKS 385

  Fly   386 LLYVPKVQPSESFNRYGT-KSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRET 449
            :|:||...|...|:.||: |||.||||||||||||:|:||||.||:|::||||||||||||||||
Mouse   386 ILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET 450

  Fly   450 LQQHKLIKVIKKKLVRKVLDMLKKIDKEAY-EKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTS 513
            ||||||:|||:||||||.|||:|||..|.| :.|||||.|||||||:||.|||:|||||||||:|
Mouse   451 LQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSS 515

  Fly   514 -NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISAL 577
             :...:|||.:|.||||.||:.||::||::|.|.|.||||||||.|||||:||.|.||||||.||
Mouse   516 HHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQAL 580

  Fly   578 PEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPC 642
            ||||||:||||||||.:.:||||:|::.|:.:..||||:.|:.|.||||:|.||.||:||:.|||
Mouse   581 PEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPC 645

  Fly   643 ALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTA 707
            ||||..:||:|||||:..:.|:|...|....||.:||||.||||||||:|::|||::.||.|.|.
Mouse   646 ALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTV 710

  Fly   708 KDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEE-----DDAEETAT 767
            .|:||::|.||||||||:|.:|..:.|.||:|:|.:|.:..:.|||.:.|||     :|||::..
Mouse   711 MDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSEDAEDSEQ 775

  Fly   768 GSQESGNADDEEEEQQHDE 786
            ...|..:|..||||::.::
Mouse   776 DEGEEMDAGTEEEEEETEK 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	HATPase_Hsp90-like	82..275	CDD:340404	124/192 (65%)
		HSP90	257..748	CDD:459703	315/495 (64%)
Hsp90b1	NP_035761.1	SRT pseudosubstrate motif. /evidence=ECO:0000250|UniProtKB:P14625	42..44		1/1 (100%)
		HATPase_Hsp90-like	83..275	CDD:340404	124/192 (65%)
		HSP90	257..775	CDD:459703	324/519 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..323		18/34 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	749..802		15/46 (33%)
		Prevents secretion from ER	799..802