Protein Alignment Gp93 and hsp-90

DIOPT Version :10

• Sequence 1: NP_651601.1
• Gene: Gp93 / 43354
• FlyBaseID: FBgn0039562
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_506626.1
• Gene: hsp-90 / 179971
• WormBaseID: WBGene00000915
• Length: 702
• Species: Caenorhabditis elegans
• Alignment Length: 719
• Identity: 339/719 - (47%)
• Similarity: 476/719 - (66%)
• Gaps: 31/719 - (4%)

  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134
            |.|:.|.||.|:.::|.||||:.|.||||:|||||||||||:||||..||:...||:|..||.|:
 Worm     3 ENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIK 67

  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199
            |..:||.|.|.|||:|||||..||:|||||||||||..|:..:|     .|.|:: |||||||||
 Worm    68 ITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 126

  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSIT--EDPRGDTLKRGSVISLYLKEEAQDFLEE 261
            ||||||||:||||:|:|||..|.|||.| .||.:.  .||.   :.||:.|.:::||:..|||||
 Worm   127 YSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPE---VTRGTKIVMHIKEDQIDFLEE 188

  Fly   262 DTVRELIRKYSQFINFPIRMWSSKTVEEEVPVEE--EAK-PEKSEDDVED--EDAKVEEAEDEKP 321
            ..::|:::|:||||.:||::...|..|:||..||  ||| .||.|.:||:  :||       :|.
 Worm   189 RKIKEIVKKHSQFIGYPIKLVVEKEREKEVEDEEAVEAKDEEKKEGEVENVADDA-------DKK 246

  Fly   322 KTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSL 386
            ||||:.:..::...:|.:||||||.|.:::.:||..|||||:.|..:.|...||..||::.|::|
 Worm   247 KTKKIKEKYFEDEELNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRAL 311

  Fly   387 LYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRETLQ 451
            |:||:..|.:.|....:| ::||||||||||.:...::||.||:||:|||||:|||||:|||.||
 Worm   312 LFVPQRAPFDLFENKKSK-NSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQ 375

  Fly   452 QHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQTSN 514
            |.|::|||:|.||:|.::::.::  ||:.::||:::|..|:|||:.||.:||.:|:..||:.||.
 Worm   376 QSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRYSTSA 440

  Fly   515 GKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISALPE 579
            |...|||.||..|||..|..||||.|.::..|..|.||||:.|:|:||||:.:.:||||:..|.|
 Worm   441 GDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKE 505

  Fly   580 FDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCAL 644
            :||||..:|.|||.:|.|:|:.||.||..|..:|.|.|.:.|: |:.::.|..||.||.:|||.:
 Worm   506 YDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDI-LEKKVEKVGVSNRLVSSPCCI 569

  Fly   645 VAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTAKD 709
            |...:||:.||||:..:.|.:   |.....|:..||.|||||.|.:|:.|..|||.|:.|.|.||
 Worm   570 VTSEYGWSANMERIMKAQALR---DSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKD 631

  Fly   710 MAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEETATGSQESGN 774
            :.|::|.||.|.||:.|:|....|..|.:|::..|.:..||..:........||....|::|..:
 Worm   632 LVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLDIGDDEIEDSAVPSSCTAEAKIEGAEEDAS 696

  Fly   775 ADDE 778
            ..:|
 Worm   697 RMEE 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp93	NP_651601.1	HATPase_Hsp90-like	82..275	CDD:340404	111/195 (57%)
		HSP90	257..748	CDD:459703	224/497 (45%)
hsp-90	NP_506626.1	HSP90	6..702	CDD:481033	337/716 (47%)