DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mfrn and MRS4

DIOPT Version :9

Sequence 1:	NP_651600.1	Gene:	mfrn / 43353	FlyBaseID:	FBgn0039561	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_012978.1	Gene:	MRS4 / 853926	SGDID:	S000001760	Length:	304	Species:	Saccharomyces cerevisiae

Alignment Length:	296	Identity:	112/296 - (37%)
Similarity:	168/296 - (56%)	Gaps:	25/296 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DYESLPT-TSVGVNMTAGAIAGVLEHVVMYPLDSVKTRMQSLS-PPTKNMNIVSTLRTMITREGL 67
            |||:||: ..:...:.|||.||::||.:|:|:|::|||:|:.. ....:..::|.:..:.|.||.
Yeast    13 DYEALPSHAPLHSQLLAGAFAGIMEHSLMFPIDALKTRVQAAGLNKAASTGMISQISKISTMEGS 77

  Fly    68 LRPIRGASAVVLGAGPAHSLYFAAYEMTKELTAKFTSVRN------LNYVISGAVATLIHDAISS 126
            :...:|..:|:|||||||::||..||..|   |:..|..:      :...:||.:||:..||:.:
Yeast    78 MALWKGVQSVILGAGPAHAVYFGTYEFCK---ARLISPEDMQTHQPMKTALSGTIATIAADALMN 139

  Fly   127 PTDVIKQRMQMYNSPYTSVVSCVRDIYKREGFKAFYRAYGTQLVMNLPYQTIHFTTYEFFQNKMN 191
            |.|.:|||:|:..:  ..|.:..:.||:.|||.|||.:|.|.|.||:|:...:|..||......|
Yeast   140 PFDTVKQRLQLDTN--LRVWNVTKQIYQNEGFAAFYYSYPTTLAMNIPFAAFNFMIYESASKFFN 202

  Fly   192 LERKYNPPVHMAAGAAAGACAAAVTTPLDVIKTLLNTQETGLTRGMIE----------ASRKIYH 246
            .:..|||.:|...|..:||..||:|||||.|||:|  |..|.....||          |||.|..
Yeast   203 PQNSYNPLIHCLCGGISGATCAALTTPLDCIKTVL--QVRGSETVSIEIMKDANTFGRASRAILE 265

  Fly   247 MAGPLGFFRGTTARVLYSMPATAICWSTYEFFKFYL 282
            :.|..||:||...|::.::|||||.|:.||..|.:|
Yeast   266 VHGWKGFWRGLKPRIVANIPATAISWTAYECAKHFL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfrn	NP_651600.1	Mito_carr	13..98	CDD:278578	32/85 (38%)
		PTZ00168	17..280	CDD:185494	105/279 (38%)
		Mito_carr	107..190	CDD:278578	30/88 (34%)
		Mito_carr	<215..282	CDD:278578	32/76 (42%)
MRS4	NP_012978.1	PTZ00168	27..252	CDD:185494	87/231 (38%)
MRS4	NP_012978.1	Mito_carr	205..304	CDD:395101	42/99 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346656
Domainoid	1	1.000	77	1.000	Domainoid score	I2088
eggNOG	1	0.900	-	-		E1_KOG0760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74739
Inparanoid	1	1.050	205	1.000	Inparanoid score	I835
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53563
OrthoFinder	1	1.000	-	-		FOG0001524
OrthoInspector	1	1.000	-	-		otm46833
orthoMCL	1	0.900	-	-		OOG6_101882
Panther	1	1.100	-	-	O	PTHR45758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1812
SonicParanoid	1	1.000	-	-		X1097
TreeFam	1	0.960	-	-
	15	14.790