Protein Alignment mfrn and UCP2

DIOPT Version :10

• Sequence 1: NP_651600.1
• Gene: mfrn / 43353
• FlyBaseID: FBgn0039561
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 72/320 - (22%)
• Similarity: 130/320 - (40%)
• Gaps: 42/320 - (13%)

  Fly     9 LPTTSVGVNMTAGAIAGVLEHVVMYPLDSVKTRMQ----SLSP-----PTKNMNIVSTLRTMITR 64
            :|.|:....:.||..|.:.: ::.:|||:.|.|:|    |..|     ..:...::.|:.||:..
Human     9 VPPTATVKFLGAGTAACIAD-LITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRT 72

  Fly    65 EGLLRPIRGASAVVLGAGPAHSLYFAA-----YEMTKELTAKFTSVRNL-NYVISGAVATLIHDA 123
            ||......|     |.||....:.||:     |:..|:...|.:...:: :.:::|:....:..|
Human    73 EGPRSLYNG-----LVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVA 132

  Fly   124 ISSPTDVIKQRMQMY-----NSPYTSVVSCVRDIYKREGFKAFYRAYGTQLVMNLPYQTIHFTTY 183
            ::.||||:|.|.|..     ...|.|.|:..:.|.:.|||:..::.....:..|.........||
Human   133 VAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197

  Fly   184 EFFQN---KMNLERKYNPPVHMAAGAAAGACAAAVTTPLDVIKTLLNTQETGLTRGMIEASRKIY 245
            :..::   |.||... :.|.|..:...||.|...:.:|:||:||.......|........:..:.
Human   198 DLIKDALLKANLMTD-DLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTML 261

  Fly   246 HMAGPLGFFRGTTARVLYSMPATAICWSTYEFFKFYLCGLDADQYKSSITGSSEPRKADY 305
            ...||..|::|.....|.......:.:.|||            |.|.::..:...|:|.:
Human   262 QKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE------------QLKRALMAACTSREAPF 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mfrn	NP_651600.1	PTZ00168	17..280	CDD:185494	66/285 (23%)
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	27/106 (25%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		25/100 (25%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		11/47 (23%)
		transmembrane domain	17..34		3/17 (18%)
		transmembrane domain	78..100		6/26 (23%)
		Mito_carr	112..206	CDD:395101	19/93 (20%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		19/88 (22%)
		transmembrane domain	120..137		2/16 (13%)
		transmembrane domain	174..197		1/22 (5%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		21/97 (22%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	20/93 (22%)
		purine nucleotide binding domain	264..273		3/8 (38%)
		transmembrane domain	269..291		3/21 (14%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		1/6 (17%)