DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mfrn and slc25a37

DIOPT Version :9

Sequence 1:	NP_651600.1	Gene:	mfrn / 43353	FlyBaseID:	FBgn0039561	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001035060.1	Gene:	slc25a37 / 387000	ZFINID:	ZDB-GENE-031118-202	Length:	332	Species:	Danio rerio

Alignment Length:	317	Identity:	164/317 - (51%)
Similarity:	212/317 - (66%)	Gaps:	38/317 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NIDDYESLPT-TSVGVNMTAGAIAGVLEHVVMYPLDSVKTRMQSLSPPTKNM--NIVSTLRTMIT 63
            |.:||||||. .|:|.:|||||:||:|||.||||:||||||||||.|..|..  ::...|:.::.
Zfish    20 NDEDYESLPAHASLGTHMTAGAVAGILEHTVMYPVDSVKTRMQSLQPDPKAQYRSVYGALKRIVR 84

  Fly    64 REGLLRPIRGASAVVLGAGPAHSLYFAAYEMTKELTAKFTSVRNLNYVI------------SGAV 116
            .||||||:||.:..||||||||:||||.||..|         |:|:.||            :|:|
Zfish    85 TEGLLRPLRGLNITVLGAGPAHALYFACYERIK---------RSLSDVIQNGGNSHIANGVAGSV 140

  Fly   117 ATLIHDAISSPTDVIKQRMQMYNSPYTSVVSCVRDIYKREGFKAFYRAYGTQLVMNLPYQTIHFT 181
            ||::|||:.:|.:|:|||||||||||.|:..||..:.::||..||||:|.|||.||:|:|.:||.
Zfish   141 ATVLHDAVMNPAEVVKQRMQMYNSPYRSLYDCVLMVSRKEGLAAFYRSYSTQLTMNIPFQAVHFI 205

  Fly   182 TYEFFQNKMNLERKYNPPVHMAAGAAAGACAAAVTTPLDVIKTLLNTQE---------TGLTRGM 237
            ||||.|...|..|:|.|..|:.:||||||.:|||||||||.||||||||         :|...||
Zfish   206 TYEFMQEHFNPHRQYRPETHIISGAAAGAVSAAVTTPLDVCKTLLNTQENVALSSAHVSGHLSGM 270

  Fly   238 IEASRKIYHMAGPLGFFRGTTARVLYSMPATAICWSTYEFFKFYLCGLDADQYKSSI 294
            :.|.|.:|.:.|...||:|..|||:|.||:|||.||.|||||::|     .|::|.:
Zfish   271 VNALRTVYRLGGVPAFFKGIQARVIYQMPSTAIAWSVYEFFKYFL-----TQHESHV 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfrn	NP_651600.1	Mito_carr	13..98	CDD:278578	52/86 (60%)
		PTZ00168	17..280	CDD:185494	151/285 (53%)
		Mito_carr	107..190	CDD:278578	47/94 (50%)
		Mito_carr	<215..282	CDD:278578	41/75 (55%)
slc25a37	NP_001035060.1	Mito_carr	30..122	CDD:278578	54/100 (54%)
		Solcar 1	31..119		52/96 (54%)
		PTZ00168	36..313	CDD:185494	151/285 (53%)
		Solcar 2	129..213		44/83 (53%)
		Mito_carr	130..218	CDD:278578	45/87 (52%)
		Solcar 3	220..314		52/93 (56%)
		Mito_carr	<240..318	CDD:278578	41/82 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6147
eggNOG	1	0.900	-	-		E1_KOG0760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74739
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2517
OMA	1	1.010	-	-		QHG53563
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	1	1.000	-	-		FOG0001524
OrthoInspector	1	1.000	-	-		otm25096
orthoMCL	1	0.900	-	-		OOG6_101882
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1812
SonicParanoid	1	1.000	-	-		X1097
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770