DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mfrn and mfn-1

DIOPT Version :9

Sequence 1:	NP_651600.1	Gene:	mfrn / 43353	FlyBaseID:	FBgn0039561	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_496447.1	Gene:	mfn-1 / 174752	WormBaseID:	WBGene00012204	Length:	312	Species:	Caenorhabditis elegans

Alignment Length:	298	Identity:	157/298 - (52%)
Similarity:	196/298 - (65%)	Gaps:	19/298 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDYESLPTTSVGVNMTAGAIAGVLEHVVMYPLDSVKTRMQSL--SPPTKNMNIVSTLRTMITREG 66
            |:||||||.||.|::||||:||.:||.||:|.||||||||||  .|.||....|.:|.:::.|||
Worm     7 DEYESLPTHSVPVHLTAGALAGAVEHCVMFPFDSVKTRMQSLCPCPETKCPTPVHSLMSIVKREG 71

  Fly    67 LLRPIRGASAVVLGAGPAHSLYFAAYEMTK-ELTAKFTSVRN-LNYVISGAVATLIHDAISSPTD 129
            .|||:||.:||..|:.|||:|||..||..| .||.......| |.|..||.|||||||||.:|.:
Worm    72 WLRPLRGVNAVAAGSMPAHALYFTVYEKMKGYLTGNSAGHSNTLAYGASGVVATLIHDAIMNPAE 136

  Fly   130 VIKQRMQMYNSPYTSVVSCVRDIYKREGFKAFYRAYGTQLVMNLPYQTIHFTTYEFFQNKMNLER 194
            |:||||||..|||.|.:.|.|.:|.|||..||||:|.|||.||:|:|.|||.:|||:|:.:|.|.
Worm   137 VVKQRMQMAFSPYGSSLECARCVYNREGVAAFYRSYTTQLAMNVPFQAIHFMSYEFWQHVLNPEH 201

  Fly   195 KYNPPVHMAAGAAAGACAAAVTTPLDVIKTLLNTQETGLT---------------RGMIEASRKI 244
            ||:|..|:.||..||..|||:|||:|.:||:||||:....               ||:.:|.|.|
Worm   202 KYDPKSHLIAGGLAGGLAAALTTPMDCVKTVLNTQQAAEADPANRRIFLQARYRYRGISDAVRTI 266

  Fly   245 YHMAGPLGFFRGTTARVLYSMPATAICWSTYEFFKFYL 282
            |...|..||..|..|||::.:||||:.||.||.|||.|
Worm   267 YSQRGLSGFSCGLQARVIFQVPATALSWSVYELFKFML 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfrn	NP_651600.1	Mito_carr	13..98	CDD:278578	49/87 (56%)
		PTZ00168	17..280	CDD:185494	144/281 (51%)
		Mito_carr	107..190	CDD:278578	51/83 (61%)
		Mito_carr	<215..282	CDD:278578	34/81 (42%)
mfn-1	NP_496447.1	Mito_carr	14..108	CDD:278578	52/93 (56%)
		Mito_carr	110..197	CDD:278578	51/86 (59%)
		Mito_carr	<223..308	CDD:278578	35/82 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167585
Domainoid	1	1.000	109	1.000	Domainoid score	I4027
eggNOG	1	0.900	-	-		E1_KOG0760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74739
Inparanoid	1	1.050	290	1.000	Inparanoid score	I1692
Isobase	1	0.950	-	0	Normalized mean entropy	S887
OMA	1	1.010	-	-		QHG53563
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	1	1.000	-	-		FOG0001524
OrthoInspector	1	1.000	-	-		oto19283
orthoMCL	1	0.900	-	-		OOG6_101882
Panther	1	1.100	-	-	LDO	PTHR45758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1812
SonicParanoid	1	1.000	-	-		X1097
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790