Protein Alignment NSD and SET1

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 1120
• Identity: 216/1120 - (19%)
• Similarity: 367/1120 - (32%)
• Gaps: 327/1120 - (29%)

  Fly   415 PDPLGQIVGNMPSHPQRSSLDNANVPIQ----VHVRFFADNGRRNWIKPENLLTFAG---LKAFD 472
            |.....::...|....|.:.||......    :...||..:...:|...:...:..|   :|...
Yeast   123 PTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSETGYYVVKELQ 187

  Fly   473 DMREELRIKHGPKSAKYRQMVPKRT-------KVVIWRQAIEEAQAMTQIPYSDR--------LE 522
            |.:.:.:|||  :..:.:...|:..       ||...|:.......:.:|.| ||        .|
Yeast   188 DGQFKFKIKH--RHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISY-DRYSLGPPPSCE 249

  Fly   523 KFYQTYENVVTLNRQ----KRKRTKY----MMQDTSDVGSSL--------YDSTD-NLHNKQGTQ 570
            ......::..|.|.|    |....||    ..:..:|..|:|        |.|:| .:::.....
Yeast   250 IVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKYASSDGKINDAAKAA 314

  Fly   571 LLAVKRERSESPFSPAFS---------------------PVK-----SKNEKRAKRRKLSNGTEA 609
            ..||::..|...|...|.                     .||     .:|.|:||.::..|....
Yeast   315 FSAVRKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQKLQENLKKAKEKEAENEKAK 379

  Fly   610 D-TGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQ 673
            : .|.:.......:.:|...||..|......||..|....:::.|...|.|....|....:.|:.
Yeast   380 ELQGKDITLPKEPKVDTLSHSSGSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKLRG 444

  Fly   674 IQLRELERDLASGEIEEPLGSSVVGRG-SGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEP 737
            .:..:.        |:.|.|..::... :...|.....:..:|:|.|....|::.......|...
Yeast   445 YRCAKF--------IDHPTGIYIIFNDIAHAQTCSNAESGNLTIMSRSRRIPILIKFHLILPRFQ 501

  Fly   738 DR-RLSEPPKTKKPVNRPIE-EVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSW 800
            :| |.::...:....|.||: |..|:.::..:|.:.:.|.:.
Yeast   502 NRTRFNKSSSSSNSTNVPIKYESKEEFIEATAKQILKDLEKT----------------------- 543

  Fly   801 LHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPE 865
            ||.|..:|                :|.||           ..||.:.......|...|....|..
Yeast   544 LHVDIKKR----------------LIGPT-----------VFDALDHANFPELLAKRELKEKEKR 581

  Fly   866 GCVICHQVESP-AVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARC 929
                 .|:.|. |.....|||::                   ||.......|...|.|:|.:.:
Yeast   582 -----QQIASKIAEDELKRKEEA-------------------KRDFDLFGLYGGYAKSNKRNLK- 621

  Fly   930 PRH----VCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPA-GTQMLNTTNI--ICPR 987
             ||    :.||           .|...||:..::..|  |.|::...: .|..||...|  :...
Yeast   622 -RHNSLALDHT-----------SLKRKKLSNGIKPMA--HLLNEETDSKETTPLNDEGITRVSKE 672

  Fly   988 H-----NIA----------------KADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRN--IP 1029
            |     |:.                |:::.                  .|.|.:.|.|...  :|
Yeast   673 HDEEDENMTSSSSEEEEEEAPDKKFKSESE------------------PTTPESDHLHGIKPLVP 719

  Fly  1030 IKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTE--------VPSNILKKA-HGEN 1085
            .:...|.:. :..|...|...||           |..:.||.|        :.|..|:.| ..|.
Yeast   720 DQNGSSDVL-DASSMYKPTATEI-----------PEPVYPPEEYDLKYSQTLSSMDLQNAIKDEE 772

  Fly  1086 DFVV--RFFGTHDHG-------------WISRRRV---------YLYIEGDTGD-----GHKTKS 1121
            |.::  :...|:...             |.|||:|         .:.:.|...|     |...|:
Yeast   773 DMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKA 837

  Fly  1122 QLFR--------NY------------TTGV-EEASRFLPIIKARRQEQDMERQSGNKLHPPPYVK 1165
            :.||        ||            |..: .|.:.:.|.:..|.:..:.|....    .|..|.
Yeast   838 EGFRKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDS----VPQEVS 898

  Fly  1166 IKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQ 1230
            ...:......||.|::|         ..:...|.|:..|:   .|:.|                :
Yeast   899 SSRDNRASNRRFQQDIE---------AQKAAIGTESELLS---LNQLN----------------K 935

  Fly  1231 RKSPRLEVVYMNE--RGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGV 1293
            ||.|   |::...  ..:||...:.||..:.:||||||.|.....:.|.::..::...:.|...|
Yeast   936 RKKP---VMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRV 997

  Fly  1294 EKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNN 1358
            :::.:|||..||.:|||:||.|:|||..:...|....|:.|:|::||..:.|||::|.::...::
Yeast   998 DENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDD 1062

  Fly  1359 SKK-ACFCGAKRCSG 1372
            .:: .|.|||..|.|
Yeast  1063 EERLPCLCGAPNCKG 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	18/112 (16%)
		PHD2_NSD	867..932	CDD:277040	12/65 (18%)
		PHD3_NSD	933..988	CDD:277041	12/57 (21%)
		PHD4_NSD	1001..1041	CDD:277042	6/41 (15%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	28/153 (18%)
		AWS	1183..1233	CDD:197795	6/49 (12%)
		SET_NSD	1233..1375	CDD:380950	46/143 (32%)
SET1	NP_011987.1	AF-4	<11..>136	CDD:461550	2/12 (17%)
		RRM_scSet1p_like	246..360	CDD:409743	20/113 (18%)
		SET_assoc	422..486	CDD:432058	12/71 (17%)
		N-SET	763..932	CDD:463344	32/184 (17%)
		SET_SET1	926..1076	CDD:380998	49/171 (29%)