Protein Alignment NSD and SET3

DIOPT Version :9

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_012954.3
• Gene: SET3 / 853900
• SGDID: S000001737
• Length: 751
• Species: Saccharomyces cerevisiae
• Alignment Length: 528
• Identity: 97/528 - (18%)
• Similarity: 164/528 - (31%)
• Gaps: 180/528 - (34%)

  Fly   986 PRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNI------PIKTNESYICEECESG 1044
            |...|...||.:....|.:....|..:.|:.|....||.|..|      |    :.|:|..|:
Yeast   106 PDSYIVDPDAGIITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAP----DDYLCNSCD-- 164

  Fly  1045 RLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWIS-----RRR 1104
                                     |.||..|:.:|...|...|.....:..:...|     |.|
Yeast   165 -------------------------PREVDINLARKIQQERINVKTVEPSSSNNSASNKNNGRDR 204

  Fly  1105 VYLYIEGDTGD---------GHKTKSQL---------FRNYTTGVEEASRFLPIIKARRQEQDME 1151
            .......|.||         .|:.|.:.         .:|.:..|..:.....:.|  ::|..:
Yeast   205 ASSTTISDVGDSFSTDQDNTNHRDKRRKRNPSNNSIDSKNESASVNSSDGLTSMPK--KKEHFL- 266

  Fly  1152 RQSGNKLHPPPYVKIKTN----KAVPPLRFSQNLED-------LSTCNCLPVDEHPCGPEAGCLN 1205
              |....:...|:.:|.|    ..:.|. .:::::|       ..|...:.::..|....|
Yeast   267 --SAKDAYGAIYLPLKDNVFKSDLIEPF-LNKHMDDNWVIQYPHKTFKSVSIEVKPYADIA---- 324

  Fly  1206 RMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINH 1270
               ::...|.:.|.|                  ||:         ::....|||:.|.:||:
Yeast   325 ---YSRTYPGFTKLG------------------VYL---------KKDCIKGDFIQEILGEL--- 356

  Fly  1271 AEFQRRMEQKQRDRDENYYFLGVEK---------DFIIDAGPKGNLARFMNHSCEPNCE------ 1320
             :|.:......|:   :|...|..|         ...|||...||..|::..||:||.|
Yeast   357 -DFYKNYLTDPRN---HYRIWGTAKRRVIFHSHWPIYIDARLSGNSTRYLRRSCQPNVELVTIKL 417

  Fly  1321 ------TQKWTVNCIHRVG--IFAIKDIPVNSELTFNYLWDD----------------------- 1354
                  ..|.:.....|:.  :.|::||..:.||...:.||.
Yeast   418 QDTDNRNDKSSGRKSSRIKFVLRALRDISEDEELYIKWQWDSKHPILKLIKGMTIDSLDDLERYG 482

  Fly  1355 LMNN-----SKKACFCG--AKRCSGEIGGKLKDDA------VKAHAKLKQMRRAKASAVRIHVKP 1406
            |:|:     |...|.||  :|.|   ...|:|..|      ||:..|:....:......:.:.|.
Yeast   483 LINSVETILSNGECGCGNNSKDC---YLLKVKRYAQSLYKSVKSRGKMNNRYKLNEILNQYNCKK 544

  Fly  1407 KKTPKVKH 1414
            ::.|.:.|
Yeast   545 RREPPILH 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898
		PHD2_NSD	867..932	CDD:277040
		PHD3_NSD	933..988	CDD:277041	1/1 (100%)
		PHD4_NSD	1001..1041	CDD:277042	11/45 (24%)
		WHSC1_related	1047..1141	CDD:99899	17/116 (15%)
		AWS	1183..1233	CDD:197795	7/56 (13%)
		SET	1234..1354	CDD:214614	32/142 (23%)
SET3	NP_012954.3	PHD_MLL5	119..163	CDD:277025	11/47 (23%)
		SET	217..722	CDD:225491	68/386 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030