DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NSD and SET2

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_012367.2	Gene:	SET2 / 853271	SGDID:	S000003704	Length:	733	Species:	Saccharomyces cerevisiae

Alignment Length:	321	Identity:	97/321 - (30%)
Similarity:	152/321 - (47%)	Gaps:	43/321 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1109 IEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVP 1173
            |..:..:|||.: :||                    .||.|:..::..|....... |..||.:.
Yeast    16 ILNNNAEGHKPQ-RLF--------------------DQEPDLTEEALTKFENLDDC-IYANKRIG 58

  Fly  1174 PLRFSQNLEDLSTCNCLPVDE------HPCGPEAGCLNRMLFNECNPEYCKA-GSLCENRMFEQR 1231
              .|..|  |...|:|  .:|      |.|..::.|:||:...||..:.|.: |:.|:|:.|:::
Yeast    59 --TFKNN--DFMECDC--YEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKK 117

  Fly  1232 KSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKD 1296
            :...:.:.....:|:|:...:.|....|:.||.||||...||:.|:....:...:::||:.::..
Yeast   118 QYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNG 182

  Fly  1297 FIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKK 1361
            ..|||..||:||||.||||.||....||.|....|:||||.:.|....|:||:|..|.....::|
Yeast   183 EFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQK 247

  Fly  1362 ACFCGAKRCSGEIGGKLKDDAVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHISADDEPM 1422
             |:|....|.|.:|||.:.||    |.|.....|.|..|.:.:: ||..|:|.:|.  ||:
Yeast   248 -CYCEEPNCIGFLGGKTQTDA----ASLLPQNIADALGVTVSME-KKWLKLKKLSG--EPI 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898
		PHD2_NSD	867..932	CDD:277040
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042
		WHSC1_related	1047..1141	CDD:99899	6/31 (19%)
		AWS	1183..1233	CDD:197795	16/56 (29%)
		SET	1234..1354	CDD:214614	43/119 (36%)
SET2	NP_012367.2	AWS	64..119	CDD:197795	16/56 (29%)
		SET_SETD2	119..260	CDD:380949	49/141 (35%)
		SET	215..695	CDD:225491	33/94 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I1445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040