Protein Alignment NSD and SDG25

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_001318731.1
• Gene: SDG25 / 834246
• AraportID: AT5G42400
• Length: 1388
• Species: Arabidopsis thaliana
• Alignment Length: 1318
• Identity: 241/1318 - (18%)
• Similarity: 415/1318 - (31%)
• Gaps: 502/1318 - (38%)

  Fly   130 SPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDS---------- 184
            |.|..||..::..:...||       :||:.:|...|.....|.|....|...|:
plant   499 SHTKYSDKPESFESFTCRV-------DSSSSKTAYSDEFDLATNGARVRGLSSDTYGTESVIASI 556

  Fly   185 ----ANQL-LS-KTYMSPIEKLLIKNGASSPNSTGFEA-----------GS--EDLGIRPIVRKH 230
                .|:| || ||:::....:|||:||::..|:..:.           ||  |...:....:|
plant   557 SEHVENELFLSLKTHLTDYTSILIKDGANNTTSSARDGKMHEENPPSLQGSFREQYNLEGSSKK- 620

  Fly   231 VKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEH 295
             |..:..|| ||:....|..:.|.:.::...:|.|..|
plant   621 -KNGLNVVP-AKLRFSNDFSDSQRLLQEGESSEQITSE--------------------------- 656

  Fly   296 KAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSP---- 356
                            ||:.| :.||::..::.|  :....:.||...|.....|.::..|
plant   657 ----------------DIIAN-IFSTALETSDIP--VNDELDALAIHEPPPPGCESNINMPCLRY 702

  Fly   357 ---PDLSSTALATSIKSPSSVSIDSAK-GLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDP 417
               |..|..:: ..||:..|:::...| ...::.|            |..:|..|:
plant   703 KYQPVRSKESI-PEIKAYVSMALCRQKLHNDVMRD------------WKSLFLKCY--------- 745

  Fly   418 LGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKH 482
            |.:.:.::....|.|..:...:.            :|..:.....|..:.:.  :...|:||
plant   746 LNEFLASLKGSHQVSRKETLALK------------KRKTVTRNKKLVQSNIS--NQTAEKLR--- 793

  Fly   483 GPKSAKYRQMVPKRTKVVIWR-QAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMM 546
                   :..|....||::.| :.:.::.:|.::...|           ..:::...||.::..|
plant   794 -------KPCVGASEKVLVKRSKKLSDSHSMKEVLKVD-----------TPSIDLSVRKPSQQKM 840

  Fly   547 QDTSDVGSSLYDSTDNLH-NKQG----TQLLAVKRE--RSESPFSPAFSPVKSKNEKRAKRRKLS 604
            ::|......:......|| .|.|    ::::..|.:  ..|..|..|....:.:...|.|.::|.
plant   841 RNTDRRDHCIIKDATKLHKEKVGKDAFSKVICDKSQDLEMEDEFDDALLITRLRRISRNKTKELR 905

  Fly   605 NGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIW 669
            ....|......::||..::|.|||...:|..             :.|:..:||:|...|
plant   906 ECRNAAKSCEEISVTAEESEETVDCKDHEES-------------LSNKPSQKVKKAHTS------ 951

  Fly   670 SLKQIQLRELERD----LASGEIE---EPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVT 727
            .||:..|.: .||    ..:|.::   |..|........|:....::|::.::...::.......
plant   952 KLKRKNLSD-ARDEGTKSCNGAVKSFTEISGKEGDTESLGLAISDKVSHQNLSKRRKKDAAKNGQ 1015

  Fly   728 PSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVR 792
            ..:.|..:.|  ||:|..|.       :|:....|.|...|     .|:..|.|..:|
plant  1016 DMSNPTGNPP--RLAEGKKF-------VEKSACSISQKGRK-----SSQSSILKRKHQ------- 1059

  Fly   793 CSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCH 857
                         |:.|::..|     ||:.|     |.|.:..||.|.
plant  1060 -------------LDEKISNVP-----SRRRL-----SLSSTDSEDAVI---------------- 1085

  Fly   858 ECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASS 922
                                      |||.....  |:||
plant  1086 --------------------------KEDYDVRN--EEKL------------------------- 1097

  Fly   923 SKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPR 987
                      .|||      |.|.|::|.:||.:
plant  1098 ----------PCHT------SDKLQKVGPNKLIR------------------------------- 1115

  Fly   988 HNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEI 1052
                                       ...|:|.|...|: |||.      ...:.||..
plant  1116 ---------------------------RRKPLAKHTTERS-PIKD------LSVDDGRPK----- 1141

  Fly  1053 VWAKFNNFRWWPAIILPPTEVPSNILKK----AHGENDFVVR--FFGTHDHGWI------SRRR- 1104
                       |..:.|..::.|...||    :..::|...|  ..|.|.|.|.      .|.|
plant  1142 -----------PIALKPLEKLSSKPSKKKLFLSIPKSDGCARTSINGWHWHAWSLKASAEERARV 1195

  Fly  1105 -----VYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYV 1164
                 |::...|       :||.|.:|             ::.||
plant  1196 RGSSCVHMQHFG-------SKSSLTQN-------------VLSAR-------------------- 1220

  Fly  1165 KIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENR--- 1226
               ||:|.                               |..:|......:..|...|...:
plant  1221 ---TNRAK-------------------------------LRNLLAAADGADVLKMSQLKARKKHL 1251

  Fly  1227 MFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFL 1291
            .|:|.|.          ..:|||..|||...|||||||||:|..:..:.|..|.::....:.|..
plant  1252 RFQQSKI----------HDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLF 1306

  Fly  1292 GVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLM 1356
            .::..:::||..:|.:|||:||||||||.|:..:|....::.|:|.:.|....|:::||.:.  :
plant  1307 RLDDGYVLDATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFP--L 1369

  Fly  1357 NNSKKACFCGAKRCSGEI 1374
            .:.|..|.|||.:|.|.:
plant  1370 EDDKIPCNCGAPKCRGSL 1387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	16/119 (13%)
		PHD2_NSD	867..932	CDD:277040	6/64 (9%)
		PHD3_NSD	933..988	CDD:277041	9/54 (17%)
		PHD4_NSD	1001..1041	CDD:277042	7/39 (18%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	19/112 (17%)
		AWS	1183..1233	CDD:197795	6/52 (12%)
		SET_NSD	1233..1375	CDD:380950	48/142 (34%)
SDG25	NP_001318731.1	SET_SETD1	1237..1384	CDD:380946	51/158 (32%)