Protein Alignment NSD and SWN

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_567221.1
• Gene: SWN / 828165
• AraportID: AT4G02020
• Length: 856
• Species: Arabidopsis thaliana
• Alignment Length: 1054
• Identity: 211/1054 - (20%)
• Similarity: 335/1054 - (31%)
• Gaps: 362/1054 - (34%)

  Fly   441 IQVHVRFFA----------DNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPK 495
            :..||..|:          |||..|.:.....:....|..|         .||.....|   ||
plant    62 VDAHVSPFSSAASSRATAEDNGNSNMLSSRMRMPLCKLNGF---------SHGVGDRDY---VP- 113

  Fly   496 RTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVG-SSLYDS 559
             ||.||        .|..::|.::|:.. |.|:   :.|:|.:|     |.:|.|.|| ..:|
plant   114 -TKDVI--------SASVKLPIAERIPP-YTTW---IFLDRNQR-----MAEDQSVVGRRQIY-- 158

  Fly   560 TDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTE 624
                :.:.|.:.| :..:..|.|        :.:.|||          |...|.:|:.....|
plant   159 ----YEQHGGETL-ICSDSEEEP--------EPEEEKR----------EFSEGEDSIIWLIGQ-- 198

  Fly   625 TTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIE 689
                                 ||.|    .|:|:..|..::|  .....|..|..|..|...:..
plant   199 ---------------------EYGM----GEEVQDALCQLLS--VDASDILERYNELKLKDKQNT 236

  Fly   690 EPLGSSVVGRGSGVGTIKRLSNRLMT---MMVRRSMTPVVTPSTTPAPSEPDRRLSEPPKTKKPV 751
            |...:|  |...|:...|.|...|.:   :..||.:   |........|:|....||    |:|.
plant   237 EEFSNS--GFKLGISLEKGLGAALDSFDNLFCRRCL---VFDCRLHGCSQPLISASE----KQPY 292

  Fly   752 NRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMP 816
            ....|.                 .|:|..|:||.....:.....|||::  |...|.|.:.
plant   293 WSDYEG-----------------DRKPCSKHCYLQLKAVREVPETCSNF--ASKAEEKASE---- 334

  Fly   817 KIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVG-----EPEGCVICHQVESP 876
                      ...||:.|.|..|..|.       |.||...:.::|     ...|....|.:...
plant   335 ----------EECSKAVSSDVPHAAAS-------GVSLQVEKTDIGIKNVDSSSGVEQEHGIRGK 382

  Fly   877 AVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDD 941
            .  ..|..:||:....:.:|                  |....||.:|.|          .|:..
plant   383 R--EVPILKDSNDLPNLSNK------------------KQKTAASDTKMS----------FVNSV 417

  Fly   942 P-------SGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH----------- 988
            |       |.|..|.|::.........|...::.:.||..:.....::|..|.|
plant   418 PSLDQALDSTKGDQGGTTDNKVNRDSEADAKEVGEPIPDNSVHDGGSSICQPHHGSGNGAIIIAE 482

  Fly   989 --NIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNI--PIKTNESYICEECESGRLPLY 1049
              ..::.....|.:...:.:||.|:....:|.||     ||:  .:||     |.:..
plant   483 MSETSRPSTEWNPIEKDLYLKGVEIFGRNSCLIA-----RNLLSGLKT-----CLDVS------- 530

  Fly  1050 GEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTG 1114
                    |..|.....:...:..|:.:|.  .|..|                       .|:..
plant   531 --------NYMRENEVSVFRRSSTPNLLLD--DGRTD-----------------------PGNDN 562

  Fly  1115 DGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQ 1179
            |....:::|||.               |.:.::.....:|..  ||..:.:|...|       :|
plant   563 DEVPPRTRLFRR---------------KGKTRKLKYSTKSAG--HPSVWKRIAGGK-------NQ 603

  Fly  1180 NLEDLSTCNCLPV-------------DEHPCGPEAGCLNRM-------------------LFNEC 1212
            :.:..:.|.||.:             .|..||....|.||.                   ...||
plant   604 SCKQYTPCGCLSMCGKDCPCLTNETCCEKYCGCSKSCKNRFRGCHCAKSQCRSRQCPCFAAGREC 668

  Fly  1213 NPEYCK-------AGSL----------CENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFV 1260
            :|:.|:       .|||          |.|.....|:..|:.:...:..|:|...:..::..:::
plant   669 DPDVCRNCWVSCGDGSLGEAPRRGEGQCGNMRLLLRQQQRILLGKSDVAGWGAFLKNSVSKNEYL 733

  Fly  1261 IEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWT 1325
            .||.||:|:|.|..:|  .|..||..:.:...:...:::||..||:..:|.|||.:|||..:...
plant   734 GEYTGELISHHEADKR--GKIYDRANSSFLFDLNDQYVLDAQRKGDKLKFANHSAKPNCYAKVMF 796

  Fly  1326 VNCIHRVGIFAIKDIPVNSELTFNY--------LWDDLMNNSKKACFCGAKRCSGEIGGKLKDDA 1382
            |...|||||||.:.|..:.||.::|        :|......||                  |||:
plant   797 VAGDHRVGIFANERIEASEELFYDYRYGPDQAPVWARKPEGSK------------------KDDS 843

  Fly  1383 VKAHAKLKQMRRAK 1396
            ...|      |||:
plant   844 AITH------RRAR 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	19/82 (23%)
		PHD2_NSD	867..932	CDD:277040	10/64 (16%)
		PHD3_NSD	933..988	CDD:277041	11/61 (18%)
		PHD4_NSD	1001..1041	CDD:277042	11/41 (27%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	11/94 (12%)
		AWS	1183..1233	CDD:197795	19/98 (19%)
		SET_NSD	1233..1375	CDD:380950	40/149 (27%)
SWN	NP_567221.1	SANT	492..536	CDD:238096	14/68 (21%)
		preSET_CXC	646..677	CDD:408079	4/30 (13%)
		SET_EZH	707..823	CDD:380917	37/117 (32%)