Protein Alignment NSD and ATX1

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_850170.1
• Gene: ATX1 / 817721
• AraportID: AT2G31650
• Length: 1062
• Species: Arabidopsis thaliana
• Alignment Length: 1370
• Identity: 240/1370 - (17%)
• Similarity: 419/1370 - (30%)
• Gaps: 531/1370 - (38%)

  Fly   185 ANQLLSKTY----MSPIEKLLIK-NGASSPNSTGFEAGSEDLGIR----PIVRKHVKRKMKRVPK 240
            ::.|:||..    :..||:..|: :|.|:.:..   ..|:|..:|    .|||.:.:|:.:  |.
plant    46 SHSLMSKKVKAQKLPMIEQFEIEGSGVSASDDC---CRSDDYKLRIQRPEIVRVYYRRRKR--PL 105

  Fly   241 AKVTLELDEKNQQEVDEKSVKTEPID-EEVDRTDEAPTQEAQTTAISIKSETEA-------EHKA 297
            .:..|:      |.|   :||||.:: :|:|..:|...::.....: :||..|:       |:.|
plant   106 RECLLD------QAV---AVKTESVELDEIDCFEEKKRRKIGNCEL-VKSGMESIGLRRCKENNA 160

  Fly   298 -----------AVDVHIKQEDT-----------IRLDIVNNPVESTSIV------------ITEE 328
                       ......|.:|.           :||..  :.|:.||.:            :..|
plant   161 FSGNKQNGSSRRKGSSSKNQDKATLASRSAKKWVRLSY--DGVDPTSFIGLQCKVFWPLDALWYE 223

  Fly   329 PKDLEKSTEELAFALPLASSTEVDL------------KSPPDLSSTALATSIKSPSSVSIDSAKG 381
            ...:..|.|...:.:......:.|:            :...:|......||..:......|....
plant   224 GSIVGYSAERKRYTVKYRDGCDEDIVFDREMIKFLVSREEMELLHLKFCTSNVTVDGRDYDEMVV 288

  Fly   382 LSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDN-ANVPIQVHV 445
            |:...|. ...::.||:.|.|:..:..||.::..:   .|:|      :|..|:| .:....:.|
plant   289 LAATLDE-CQDFEPGDIVWAKLAGHAMWPAVIVDE---SIIG------ERKGLNNKVSGGGSLLV 343

  Fly   446 RFFA--DNGRRNWIKPENLLTF-AGLKAFDDMR-EELRIKHGPKSAKY---RQMVPKRTKVV--- 500
            :||.  |..|   ||.:..::| .||.:...:: ::.|.:.|.:.||.   ...:|:|...:
plant   344 QFFGTHDFAR---IKVKQAISFIKGLLSPSHLKCKQPRFEEGMQEAKMYLKAHRLPERMSQLQKG 405

  Fly   501 --------------------------IWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKR 539
                                      :|.:..|...             |.....:::.:|..|.
plant   406 ADSVDSDMANSTEEGNSGGDLLNDGEVWLRPTEHVD-------------FRHIIGDLLIINLGKV 457

  Fly   540 KRTKYMMQDTSDVGSSLYDS-------TDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKR 597
            .......:|.:.:....|.:       ||  |:......:.|.|: :|:...|.|.
plant   458 VTDSQFFKDENHIWPEGYTAMRKFTSLTD--HSASALYKMEVLRD-AETKTHPLFI--------- 510

  Fly   598 AKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLL 662
                     ..||:|......|||                          ...|:...:::||..
plant   511 ---------VTADSGEQFKGPTPS--------------------------ACWNKIYNRIKKVQN 540

  Fly   663 SVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVT 727
            |...||                       ||..:.|.|              |.|...|...|:.
plant   541 SDSPNI-----------------------LGEELNGSG--------------TDMFGLSNPEVIK 568

  Fly   728 PSTTPAPSEPDRRLS----------EPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKY 782
            .....:.|.|...:|          ..|...:||            ::|.|.|.:       |..
plant   569 LVQDLSKSRPSSHVSMCKNSLGRHQNQPTGYRPV------------RVDWKDLDK-------CNV 614

  Fly   783 CYQ----AGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTAD 843
            |:.    ..:..::|.: |...:||.|...                 :.|..
plant   615 CHMDEEYENNLFLQCDK-CRMMVHAKCYGE-----------------LEPCD------------- 648

  Fly   844 AKEVVAVGTSLVCHECNVGEPE---GCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMC 905
                   |...:|:.|..|.|:   .|.:|..|.....|:|.
plant   649 -------GALWLCNLCRPGAPDMPPRCCLCPVVGGAMKPTTD----------------------- 683

  Fly   906 GKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQL-GSSKLAKCVRCPATYHQLSK 969
            |:..|.:|..:.|:                ||:||  ..|.:.: |.:|::|
plant   684 GRWAHLACAIWIPE----------------TCLSD--VKKMEPIDGVNKVSK------------- 717

  Fly   970 CIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYIC-VKGGELVCC--ETCPIAVHAHCRNIPIK 1031
                            .|..          |.|.|| |..|..:.|  .:|.:|.|      |:.
plant   718 ----------------DRWK----------LMCTICGVSYGACIQCSNNSCRVAYH------PLC 750

  Fly  1032 TNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHD 1096
            ...:.:|.|.                                          |||
plant   751 ARAAGLCVEL------------------------------------------END---------- 763

  Fly  1097 HGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPP 1161
                      :.:||:..|                 :..|.|...|..||.......|.:::...
plant   764 ----------MSVEGEEAD-----------------QCIRMLSFCKRHRQTSTACLGSEDRIKSA 801

  Fly  1162 PYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPC-------GPE--AGCLNRMLFNECNP--- 1214
            .:   ||::.:||...|         .|...:.:.|       .||  |...::.||.|..|
plant   802 TH---KTSEYLPPPNPS---------GCARTEPYNCFGRRGRKEPEALAAASSKRLFVENQPYVI 854

  Fly  1215 ------EYCKAGSLCENRMFEQRKSPRL-----EVVYMNE-------------RGFGLVNREPIA 1255
                  |:....|:..:::.:......:     :..||.|             .|||:..:.|..
plant   855 GGYSRLEFSTYKSIHGSKVSQMNTPSNILSMAEKYRYMRETYRKRLAFGKSGIHGFGIFAKLPHR 919

  Fly  1256 VGDFVIEYVGEVINHAEFQRRMEQKQRDR-DENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNC 1319
            .||.:|||.||::..:...:|.:...... ....|...::.:.:|||...|::|..:||||.|||
plant   920 AGDMMIEYTGELVRPSIADKREQLIYNSMVGAGTYMFRIDDERVIDATRTGSIAHLINHSCVPNC 984

  Fly  1320 ETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLKDDAVK 1384
            .::..|||....:.|||.:.||...|||::|.:..:  ..:.:|.||...|.|.:.   ..:|.:
plant   985 YSRVITVNGDEHIIIFAKRHIPKWEELTYDYRFFSI--GERLSCSCGFPGCRGVVN---DTEAEE 1044

  Fly  1385 AHAKL 1389
            .|||:
plant  1045 QHAKI 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	29/155 (19%)
		PHD2_NSD	867..932	CDD:277040	9/64 (14%)
		PHD3_NSD	933..988	CDD:277041	8/55 (15%)
		PHD4_NSD	1001..1041	CDD:277042	11/42 (26%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	8/94 (9%)
		AWS	1183..1233	CDD:197795	11/67 (16%)
		SET_NSD	1233..1375	CDD:380950	45/160 (28%)
ATX1	NP_850170.1	Tudor_Agenet_AtEML-like	207..257	CDD:410475	4/49 (8%)
		PWWP_AtATX1-like	300..396	CDD:438970	25/107 (23%)
		FYRN	447..497	CDD:461787	7/51 (14%)
		FYRC	508..597	CDD:470645	24/169 (14%)
		PHD_ATX1_2_like	611..657	CDD:276969	10/90 (11%)
		ePHD_ATX1_2_like	668..784	CDD:277132	40/280 (14%)
		SET_SETD1-like	885..1034	CDD:380916	43/150 (29%)