Protein Alignment NSD and CLF

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_179919.1
• Gene: CLF / 816870
• AraportID: AT2G23380
• Length: 902
• Species: Arabidopsis thaliana
• Alignment Length: 1050
• Identity: 197/1050 - (18%)
• Similarity: 336/1050 - (32%)
• Gaps: 367/1050 - (34%)

  Fly   484 PKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNR---------QKR 539
            |.|:..|...||            ::.|..:.|.|..:.:..::.:..:..:|         :.:
plant     7 PSSSATRSEPPK------------DSPAEERGPASKEVSEVIESLKKKLAADRCISIKKRIDENK 59

  Fly   540 KR----TKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKR 600
            |.    |:..|:.:.:.|.|..|.:|          |.|||:| :||      .:||..::....
plant    60 KNLFAITQSFMRSSMERGGSCKDGSD----------LLVKRQR-DSP------GMKSGIDESNNN 107

  Fly   601 RKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVV 665
            |.:.:|.     ::|..|..|.....:.....:.|:.:: ||....:|.::|:....|
plant   108 RYVEDGP-----ASSGMVQGSSVPVKISLRPIKMPDIKR-LSPYTTWVFLDRNQRMTE------- 159

  Fly   666 SNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPST 730
                                       ..||||                    ||.:....|...
plant   160 ---------------------------DQSVVG--------------------RRRIYYDQTGGE 177

  Fly   731 TPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDIL-QLDSKYLFRGLSREPICKYCYQAGSDLVRCS 794
            ....|:.:....:..:.|:....|.:.:|...| ||       |||...:.:.
plant   178 ALICSDSEEEAIDDEEEKRDFLEPEDYIIRMTLEQL-------GLSDSVLAEL------------ 223

  Fly   795 RTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDH----VTADAKEVVAVGTSLV 855
                    |..|.|..:     :|.:|..:::.....|.|.|...    :..|.:..:....:|.
plant   224 --------ASFLSRSTS-----EIKARHGVLMKEKEVSESGDNQAESSLLNKDMEGALDSFDNLF 275

  Fly   856 CHECNVGE--PEGCV--ICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGK------RF- 909
            |..|.|.:  ..||.  :....|.|| |..|         |: |:.|||. ..|.|      ||
plant   276 CRRCLVFDCRLHGCSQDLIFPAEKPA-PWCP---------PV-DENLTCG-ANCYKTLLKSGRFP 328

  Fly   910 ---------HTSC----CKYWPQASSSKHSARCPR----------HVCHTCVSDDPSGKFQQLGS 951
                     .||.    .|..|...|||.:.|.|:          ..|....||..:|..|...|
plant   329 GYGTIEGKTGTSSDGAGTKTTPTKFSSKLNGRKPKTFPSESASSNEKCALETSDSENGLQQDTNS 393

  Fly   952 SKLAKCVRCPAT---------YHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVK 1007
            .|::...:...:         .:::::.:|..||...           .|.:|           .
plant   394 DKVSSSPKVKGSGRRVGRKRNKNRVAERVPRKTQKRQ-----------KKTEA-----------S 436

  Fly  1008 GGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTE 1072
            ..:.:...:|..:...|..|....::.....:...||:....|                  .|.|
plant   437 DSDSIASGSCSPSDAKHKDNEDATSSSQKHVKSGNSGKSRKNG------------------TPAE 483

  Fly  1073 VPSNILK---------------KAHGENDFVVR--FFG-THDHGWISRRRVYLYIEGDTGD---- 1115
            |.:|.:|               .|.|.::.:.:  |.| |...|.::..:::..:|....|
plant   484 VSNNSVKDDVPVCQSNEVASELDAPGSDESLRKEEFMGETVSRGRLATNKLWRPLEKSLFDKGVE 548

  Fly  1116 ---------------GHKTKSQLFRNYTTGVEEASRF------------------LPIIKARRQE 1147
                           |.|:..::|:..|....:||.|                  :...:.||:.
plant   549 IFGMNSCLIARNLLSGFKSCWEVFQYMTCSENKASFFGGDGLNPDGSSKFDINGNMVNNQVRRRS 613

  Fly  1148 QDMERQSGNKLHPPPYV----------KIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAG 1202
            :.:.|:  .|:....|.          |..|.|...|.|      ..:.|||    :..||.|..
plant   614 RFLRRR--GKVRRLKYTWKSAAYHSIRKRITEKKDQPCR------QFNPCNC----KIACGKECP 666

  Fly  1203 CL-----------------NRM-------------------LFNECNPEYCK-------AGSL-- 1222
            ||                 ||.                   ...||:|:.|:       .|||
plant   667 CLLNGTCCEKYCGCPKSCKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVIGGDGSLGV 731

  Fly  1223 ---------CENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRME 1278
                     |.|.....::..|:.:...:..|:|...:..::..:::.||.||:|:|.|..:|
plant   732 PSQRGDNYECRNMKLLLKQQQRVLLGISDVSGWGAFLKNSVSKHEYLGEYTGELISHKEADKR-- 794

  Fly  1279 QKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVN 1343
            .|..||:...:...:...|::||..||:..:|.|||.||||..:...|...|||||||.:.|...
plant   795 GKIYDRENCSFLFNLNDQFVLDAYRKGDKLKFANHSPEPNCYAKVIMVAGDHRVGIFAKERILAG 859

  Fly  1344 SELTFNYLWD 1353
            .||.::|.::
plant   860 EELFYDYRYE 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	6/29 (21%)
		PHD2_NSD	867..932	CDD:277040	24/96 (25%)
		PHD3_NSD	933..988	CDD:277041	10/63 (16%)
		PHD4_NSD	1001..1041	CDD:277042	3/39 (8%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	21/149 (14%)
		AWS	1183..1233	CDD:197795	19/103 (18%)
		SET_NSD	1233..1375	CDD:380950	39/120 (33%)
CLF	NP_179919.1	preSET_CXC	690..721	CDD:408079	4/30 (13%)
		SET_EZH	752..868	CDD:380917	39/117 (33%)