DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and KMT2D

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_011537072.1	Gene:	KMT2D / 8085	HGNCID:	7133	Length:	5556	Species:	Homo sapiens

Alignment Length:	1709	Identity:	318/1709 - (18%)
Similarity:	509/1709 - (29%)	Gaps:	623/1709 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GDAAHGNVLCNSASDS-----LTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVR-LLDKPGQN 71
            |..:||.:...|:|::     |.|...|:.|:.....|:          |...|.: :|::|.||
Human  4115 GGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQ----------NLLGPQQPMLERPMQN 4169

  Fly    72 PVQNGAQPAAEESELESQRQTP---------------------------VQKQQQQRVSMVNRKR 109
              ..|.||......|:|.:..|                           :..||||::..:..:|
Human  4170 --NTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQR 4232

  Fly   110 DLINLQSA-LSPKYIGYANANSPT-------------------PLSD--SDDTIRTTRRRVNQAA 152
            .|...|:. .:|.|.......||.                   ||.:  :....:...|......
Human  4233 QLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPG 4297

  Fly   153 ALNNSSAGETL--AHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFE 215
            ||   |.|..|  .|....|.:|      ......:||.|.:...|.|..|......:|...|..
Human  4298 AL---STGPVLGPVHPTPPPSSP------QEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPT 4353

  Fly   216 AGSEDLGIRPIVRK-----------------HVKRKMKRVPKAKVTLELDEKNQQ---EVDEKSV 260
            .......:.|...:                 ::....|....:.|...||:.|.|   |..:.|:
Human  4354 LEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSI 4418

  Fly   261 KTEPIDEEVDRTDEAPTQEAQTTAISIKS----------ETEAEH-------------------- 295
            |.||.:|......::..:||....|....          .:||.|
Human  4419 KQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGS 4483

  Fly   296 ---KAAVDVHIKQ-----EDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVD 352
               :|.::.||..     |..::....|....:....:|.:||.::|:::.      |.||.:..
Human  4484 EGLRAEINGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDR------LVSSRKKL 4542

  Fly   353 LKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDP--------------GWP---------TYQ 394
            .|.....:|.||...:|...|        |..:|:|              |.|         .:.
Human  4543 RKEDGVRASEALLKQLKQELS--------LLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFG 4599

  Fly   395 VGDLFWGKVFSYCFWPCMVCPDPLGQI-----VGNMPSHPQRSSLDNANVPIQVHVRFFADNGRR 454
            .|.|..|             ||...|:     :.|.|:.|  |||. ...|..|..:..
Human  4600 SGALPTG-------------PDYYSQLLTKNNLSNPPTPP--SSLP-PTPPPSVQQKMV------ 4642

  Fly   455 NWIKPEN------------------LLTFAGLKAFD----------DMREELRIKHGPKSAKYRQ 491
            |.:.|..                  |...:.:|:.|          :..|::|::....|.....
Human  4643 NGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDS 4707

  Fly   492 MVPKRTKVVI---------------WRQAIEEAQAMTQIPYSDR--LEKFYQT--YENVVTLNRQ 537
            :||..:...|               |.|  |:......||...|  :..|..|  |..:......
Human  4708 IVPASSPESILGEEAPRFPHLGSGRWEQ--EDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPG 4770

  Fly   538 KRKRTKYMMQDTSDVGSSLYDSTDNLHNKQG-----TQLLAVKRERS------ESPFSPAFSPVK 591
            |...|.:.....|:|...|..|.....|..|     .:||::|...|      |||......|.|
Human  4771 KLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKK 4835

  Fly   592 SKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVME-YVMMNRSDE 655
            .:.|....:.|...|...|||                      |::.:...||:. |.:.::.|
Human  4836 GEAEGPGGKEKGLEGKSPDTG----------------------PDWLKQFDAVLPGYTLKSQLD- 4877

  Fly   656 KVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRR 720
                 :||:      |||          .|...|.|...|.....|.: .:::||
Human  4878 -----ILSL------LKQ----------ESPAPEPPTQHSYTYNVSNL-DVRQLS---------- 4910

  Fly   721 SMTPVVTPSTTPAPSEPDRRLSEPPK--TKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYC 783
                      .|.|.||    |.||.  ...|.:.|.|.::|             |..||
Human  4911 ----------APPPEEP----SPPPSPLAPSPASPPTEPLVE-------------LPTEP----- 4943

  Fly   784 YQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDH--------- 839
                                  |......:|:|...|.::....|.::.|...||.
Human  4944 ----------------------LAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWK 4986

  Fly   840 ----------VT--------ADAKEVV----AVGTSLVCHECNVGEPE-------GCVICHQVES 875
                      :|        .|.:||.    .:||:|        .|:       .|..||:
Human  4987 GVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTAL--------RPDKVPRDMRRCCFCHE--- 5040

  Fly   876 PAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHV------- 933
                    :.|.::..|.  :||.....:.   .|.:|..:..:...::..|.....|
Human  5041 --------EGDGATDGPA--RLLNLDLDLW---VHLNCALWSTEVYETQGGALMNVEVALHRGLL 5092

  Fly   934 --CHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNI-AKADA 995
              |..|         |:.|::.....:|||..|| .:..|.|.........::||.|.| ...:.
Human  5093 TKCSLC---------QRTGATSSCNRMRCPNVYH-FACAIRAKCMFFKDKTMLCPMHKIKGPCEQ 5147

  Fly   996 HVNVLWCY---------------ICVKGGELVCCETCPIAVHAHCRNIP---------------- 1029
            .::....:               |..:|..|.......:..||..:.:|
Human  5148 ELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVG 5212

  Fly  1030 ---------IKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGEN 1085
                     ::||....|..|..|.            ||.|  |..::...|         .|..
Human  5213 YEATRIYWSLRTNNRRCCYRCSIGE------------NNGR--PEFVIKVIE---------QGLE 5254

  Fly  1086 DFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEA--SRFLPIIKARRQEQ 1148
            |.|                                      :|....:|  :|.:..:.|.|:|.
Human  5255 DLV--------------------------------------FTDASPQAVWNRIIEPVAAMRKEA 5281

  Fly  1149 DMERQSGNKLHPPPYVKIK-----TNKAVPPLRFSQNLEDLSTCNC------------LPVDEHP 1196
            ||.|..      |.|:|.:     |..||  ||.:::|..:.:|..            ||:..:|
Human  5282 DMLRLF------PEYLKGEELFGLTVHAV--LRIAESLPGVESCQNYLFRYGRHPLMELPLMINP 5338

  Fly  1197 CG-----PEAGCLNRMLF----------NECNPEYCKAGSLCE--------------NRMFEQRK 1232
            .|     |:.....:.:|          |...|....:.|:.:              ::.|...|
Human  5339 TGCARSEPKILTHYKRVFTSIISFDPHNNLMRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSK 5403

  Fly  1233 SP---RLEVVYMNE--------RGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDE 1286
            |.   ||...:.|.        :|.||...:.:.....||||:|.:|.: |...|.|:...:::.
Human  5404 SSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRN-EVANRREKIYEEQNR 5467

  Fly  1287 NYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYL 1351
            ..|...:..:.:|||...|..||::||||.|||..:..|.:...::.|.:.:.||...|||::|.
Human  5468 GIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQ 5532

  Fly  1352 WDDLMNNSKKACFCGAKRC 1370
            :|...:..|..|.|||..|
Human  5533 FDFEDDQHKIPCHCGAWNC 5551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	28/173 (16%)
		PHD2_NSD	867..932	CDD:277040	10/64 (16%)
		PHD3_NSD	933..988	CDD:277041	14/63 (22%)
		PHD4_NSD	1001..1041	CDD:277042	9/79 (11%)
		WHSC1_related	1047..1141	CDD:99899	11/95 (12%)
		AWS	1183..1233	CDD:197795	11/90 (12%)
		SET	1234..1354	CDD:214614	37/130 (28%)
KMT2D	XP_011537072.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940