Protein Alignment NSD and setd2

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_009290459.2
• Gene: setd2 / 794199
• ZFINID: ZDB-GENE-030131-2140
• Length: 2737
• Species: Danio rerio
• Alignment Length: 1486
• Identity: 324/1486 - (21%)
• Similarity: 537/1486 - (36%)
• Gaps: 435/1486 - (29%)

  Fly    38 GNDESVATEGDDVEIPRDTNNSTPVRLL--DKPGQNPVQNGAQPAAEESELESQRQT-----PVQ 95
            |:|.|.::.....:  :|:.:||..|..  .||......:.:...|:.|:.||.|::     .|.
Zfish   417 GSDSSRSSTYSSSQ--KDSKSSTHSRSHRDSKPTDCSRSSESDKRAQHSKSESNRRSSSEIDAVH 479

  Fly    96 KQQQQRVSM-VNRKRDLINL--QSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNS 157
            |:...|..: ||.|....||  .|..|.|.|...:       ||||:..|  |:|.:|.:
Zfish   480 KKSSARTKLEVNDKISNSNLTTSSRTSEKKIHKTS-------SDSDEEHR--RKRQSQGS----- 530

  Fly   158 SAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNS----TGFEAGS 218
                     :.|||:        |..|:.                ||.....||    ||.|..|
Zfish   531 ---------DRSPRS--------GTSSSR----------------KNDLVDHNSFNIGTGTERQS 562

  Fly   219 EDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTT 283
            .|       |.:...|..::....||   .:|....:|::.  |.|    ..:.......||...
Zfish   563 TD-------RLNTNAKDSQLVFVTVT---SQKESSNIDDQC--TPP----KSKNSSQQMHEATHK 611

  Fly   284 AISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASS 348
            ....::..:|||:.:      .:|...|:...|..||            :|:||.|..::.:.|.
Zfish   612 VNLCETNKKAEHQPS------NQDLSSLEKCTNVPES------------KKTTERLTESISITSG 658

  Fly   349 TEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMV 413
             :::::||.::....:..::...|.| :...:..||...|....:.:|.|
Zfish   659 -KLEVRSPTEVDEPGMKVTVPIQSEV-LTVGQTESICVGPAPSEHTMGSL--------------- 706

  Fly   414 CPD--------PLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKA 470
             .|        |.|.::.|..|......:...:.|:.:.|:....:..:|...||...|  |:..
Zfish   707 -TDSLSVKELPPEGSLILNTKSDESSLIISQISTPVTLTVQPCEKDSEQNIGSPEQPNT--GISK 768

  Fly   471 FDDMREELRIK-HGPKSAKYR---QMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENV 531
            .|...::.|.. .|..:::|:   ::|....|.|:..|.||.:.. |....|.:|:....:.::|
Zfish   769 KDASAKKSRWDIVGQVTSEYQSPAKLVNPDVKKVMLAQKIEFSDT-TPDNCSQKLDPEVPSEKSV 832

  Fly   532 VTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEK 596
                                          .:|.:..|   |.:..:..|.|:..|. .|..:::
Zfish   833 ------------------------------EVHARDTT---AAESHQEISSFTSNFG-TKGTHDE 863

  Fly   597 RAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVL 661
            ..|..::...|.|...|:   ..||:.:..||.:   .||.:...|  :.:.....||:
Zfish   864 LQKTVEIPQSTSALVVSD---FQPSKEKVNVDKT---KPEIQDPDS--LNHDGKCHSDD------ 914

  Fly   662 LSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVV 726
                                    .|.||....|..||.|    :|||.:   .::|.::.|..:
Zfish   915 ------------------------SESEESDSDSDDGRVS----LKRLHS---VVVVPKNSTIAL 948

  Fly   727 --TPSTTPAPSEPDRRLSEPPKTKKPVNR--PIEEVIEDILQLDSKYLFRGLSREPICK------ 781
              .....|||:......::...|.:.:|:  |.....:..|:..|..|::| |.:..|:
Zfish   949 ETNDKAEPAPASSLFSGNQQTDTHESINKEFPYGFNNQSTLKESSAALYKG-SAQAACQSPNVKG 1012

  Fly   782 YCYQAGSDLVRCSRTCSSWLHADCLERKV----TGAPMPKI-GSRKALVIPPTSKS-PSPDEDHV 840
            ..||:.|::|      .|..|.:.:...|    :....|.| |......:....|: ..|:.||.
Zfish  1013 VSYQSQSNMV------DSTSHLEVMSAHVDKNWSAQERPNISGQINQEYVQNFEKTCEKPETDHH 1071

  Fly   841 TADAKE----------VVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIED 895
            ....:.          .|..|.|||..            .:|.|.|:  ||.::.|||..||
Zfish  1072 QYHGRPDSWNGRKGDFSVGRGDSLVWD------------FNQSEQPS--STFQQPDSSYSTP--- 1119

  Fly   896 KLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHV---CHTCV------------SDDPSGK 945
                  ||:... .|..  ..|.|.:.||.|.....||   .|..|            .||..|:
Zfish  1120 ------QPLFDS-VHRE--DPWAQPAISKTSRTVNTHVPFQYHDLVHQIHPDSLTNDHDDDREGR 1175

  Fly   946 FQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGE 1010
            ...:..:.|            ||..:|..:..:....
Zfish  1176 ILGIKQASL------------LSAGLPGPSPFVQAPE---------------------------- 1200

  Fly  1011 LVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPS 1075
                               |.:|.|:..|.                 .|.          :|.|.
Zfish  1201 -------------------ISSNCSFTTES-----------------QNI----------SEAPR 1219

  Fly  1076 NILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDT-GDGHKTKSQLFRNYTTGVEEASRFLP 1139
            :..:|.|            ...|...:||.....|.|. .:...:|.:.|       :|:||  |
Zfish  1220 DDNQKPH------------RGRGPPKKRRQEFESESDNEAEAGLSKRECF-------DESSR--P 1263

  Fly  1140 IIKAR---RQEQDMER----------------QSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLS 1185
            :..|:   .|.|:::|                ::..|..||.:..|:.|..:...:.:::..|:.
Zfish  1264 LKDAKESFHQIQEVQRPLLSLKEFSDPFVWRDKAKQKKMPPYFDLIEENLYLTERKKNKSHRDIK 1328

  Fly  1186 --TCNC--LPVDEH-----PCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYM 1241
              .|.|  |..:|.     .||.:  ||||:|..||:.. |..|:.|.||.|:.::....||:..
Zfish  1329 RMQCECAILSKEERARGILACGED--CLNRLLMIECSSR-CLNGAYCSNRRFQMKQHADYEVILT 1390

  Fly  1242 NERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGN 1306
            ..:|:||...:.:....||:||.|||::|.||:.|:::..|:::.:|||:.::.:.||||..|||
Zfish  1391 ESKGWGLRAAKDLQPNTFVLEYCGEVLDHREFKARVKEYARNKNIHYYFMALKNNEIIDATLKGN 1455

  Fly  1307 LARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCS 1371
            .:|||||||||||||||||||...|:|.|..|.:...:||||:|.:......::| |||||..|.
Zfish  1456 CSRFMNHSCEPNCETQKWTVNGQLRIGFFTTKAVTAGTELTFDYQFQRYGKEAQK-CFCGAPSCR 1519

  Fly  1372 GEIGGKLKDDAVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHISADDEPMDAKDE 1427
            |.|||:.: .:|:|....||..|:         :.|.|...  ::..||.::|..|
Zfish  1520 GLIGGETR-VSVRAAGGKKQRERS---------RKKDTDSA--LTTLDEELEALQE 1563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	24/130 (18%)
		PHD2_NSD	867..932	CDD:277040	18/64 (28%)
		PHD3_NSD	933..988	CDD:277041	10/69 (14%)
		PHD4_NSD	1001..1041	CDD:277042	4/39 (10%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	16/95 (17%)
		AWS	1183..1233	CDD:197795	20/58 (34%)
		SET_NSD	1233..1375	CDD:380950	63/141 (45%)
setd2	XP_009290459.2	None