DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and setd1b

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_001072649.1 Gene:setd1b / 780106 XenbaseID:XB-GENE-5842344 Length:1956 Species:Xenopus tropicalis


Alignment Length:1760 Identity:336/1760 - (19%)
Similarity:553/1760 - (31%) Gaps:612/1760 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 STDAHSEIEGDAAHGNVLCNSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKP 68
            ::|::|    ||.     |||||..|....|..   :|....|.|.....:.:.:.||.| .:.|
 Frog   419 TSDSYS----DAG-----CNSASLELKPVKEKP---EEPPPPEPDSTTEQKASFSQTPER-CETP 470

  Fly    69 GQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTP 133
            |                      ||..:.:.|..|:..|...|:..|........|..|      
 Frog   471 G----------------------TPTLEAELQHNSLDTRIAMLLKEQRTQLHLIAGDQN------ 507

  Fly   134 LSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIE 198
               ||:.||.      :.:.:::||:       ..||..|...|....|           ::|  
 Frog   508 ---SDNEIRM------EGSPISSSSS-------QLSPIPPYSSGSRYQD-----------VTP-- 543

  Fly   199 KLLIKNGASSPNSTGFEAGSEDLGIRPIV-----RKHVKRKMKRVPKAKVTLELDEKNQQEVDEK 258
                   :|.|:|||.    ||:...|:.     .:.:.........::....:|:.||     .
 Frog   544 -------SSRPSSTGL----EDISPTPLPDSDDDDEPIPGTASLCQNSRSASPIDQINQ-----S 592

  Fly   259 SVKTEPID-EEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTS 322
            ..|||.:| :|:...||.||.|..         .|....:..|:.|..:     ::..:|:.|..
 Frog   593 GRKTESLDKKELVAGDETPTSEKM---------DEGHPSSGEDMEISDD-----EVTPSPITSAE 643

  Fly   323 IVITEEPKDLEKSTEELAFALPLASSTEVDL-KSPPDLSSTALATSIKSP-----SSVSIDSAKG 381
            ..||        |:..::..:|:.......| ..||......:...:..|     .||::...  
 Frog   644 CAIT--------SSSVISSVIPIPPPGFPPLPPPPPPQPGFPMPPPLPPPPPPTHPSVTVPPP-- 698

  Fly   382 LSIVTDPGWPTYQV---------------------GDLFWGKVFSYCFWPCMVCPDPLGQIVGNM 425
             .:...||.|.:.:                     |:.:.|...|:.....|:.....||  |:.
 Frog   699 -PLPAPPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMMQGQ--GSY 760

  Fly   426 PSH---------------------------------------------------PQRSSLDNANV 439
            |.|                                                   |.::::|..  
 Frog   761 PYHHFMGGSMQFGNQHPYRPFAISAHLTRGQPWPPFPKFDPSVPPPGYEHKKEDPHKATVDGV-- 823

  Fly   440 PIQVHVRFFADNGRRNWIKPENLLTFAGLKAFD---DMREELR------IKHGPKSAKYRQMVPK 495
             :||.|:......:|:..:  .::.....:|||   |.:|.|.      :|.|....:.:|    
 Frog   824 -LQVIVKELKAIMKRDLNR--KMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGESKEEDKQ---- 881

  Fly   496 RTKVVIWRQAIEEAQAMTQIPYSD-----------RLEKF---YQTYENVVTLNRQKRKRTKYMM 546
            :||..|....:|.......:.:..           ||..|   .:...:......|||.|..:.:
 Frog   882 KTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIRPSHSV 946

  Fly   547 QDTS-------DVGSSLYD----STDNLHNKQ--GTQLLAVKRERSESPFSPAFSPVK--SKNEK 596
            .|..       |:.|:..|    ..|.::|::  ...|.:...|..||......:..|  |.:||
 Frog   947 DDEDEESERDRDISSTASDLSKKDADAVNNRRRPARPLDSEGEEEVESEGDDGETSDKEDSSSEK 1011

  Fly   597 R----------AKRRKLSNGTEAD--------TGSNSMAVTPSQTETTVDSSAYENPEFRQLLSA 643
            .          :.:::|....|.|        :|.....|:..:..|:|.||..|.....:...:
 Frog  1012 EDQDDGSVSALSSKKQLYGDKEGDDEDDDTQSSGKEEDLVSEEEDTTSVASSRAEMDSSDESEES 1076

  Fly   644 VMEYVMMNRSDEKVE-----------------------------------KVLLSVVSNIWSLKQ 673
             .||...:.||||.|                                   :..||..|::.....
 Frog  1077 -SEYESSSDSDEKEEEDDEEEELVFGDDQSEDQDLGQEYEVETDREEDFFRENLSECSSLPKAGD 1140

  Fly   674 IQL----RELERDLASGEIEE-----------PLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMT 723
            ::|    :::|.|:|....:|           ||..|...:...:..:::|....|...|.:...
 Frog  1141 VELEDEMQKVEEDVARQTTQETLHLRKKNLDVPLVESKECKQDTLDKVEKLFAVPMQEEVFKEHE 1205

  Fly   724 PVVTP----------STTPAPSEPDRRLSEPPKTKKPV-NRPIEEV-----IEDILQLDSKYLFR 772
            ...:|          ...|.|..|:   ...|..::|| .||:...     ...:|:|:...|..
 Frog  1206 KAPSPMNEEEEYIELQLEPVPLVPE---GAAPAAQEPVIIRPLTPTGAFGETGPVLKLEEPKLQV 1267

  Fly   773 GLSR---EPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPS 834
            .|::   |....|....|.|..         .|:|   .:||..|..|:.......:|..:|...
 Frog  1268 NLTQFATEDEELYPRTPGRDTA---------AHSD---TEVTFQPGLKVAPSSLPFLPSHNKEEE 1320

  Fly   835 ---PDEDH-----VTADAKE---VVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSS 888
               |.|.|     ||....|   ....|..:|....::|:.:        .:..||:||     .
 Frog  1321 CLLPPEKHAGHLTVTKMLSEEDLPRTPGRDIVVKSSHLGKSQ--------STETVPATP-----G 1372

  Fly   889 SHTPIEDKLLTCSQP-MCGKRFHTSCCKYWPQASSSKHSARCPR------------------HVC 934
            |..|:....||.:.| :.|..|     .|..|:....:|. .||                  ..|
 Frog  1373 SDAPLTGSSLTLTSPHIPGSPF-----SYLSQSPGIINSG-IPRTPGRDFNFTPTFPESNSIFPC 1431

  Fly   935 HTCVSDDPSGK-----------FQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH 988
            |      ||||           |::..|:.|        |.:.:...||..:          |..
 Frog  1432 H------PSGKKPSVDEPDEKSFKEPTSASL--------TMNSVPSPIPFAS----------PPR 1472

  Fly   989 NIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICE--ECESGRLPLYGE 1051
            .:...|         |.:...:|...:|            |...::..:.|  |||..::.|...
 Frog  1473 GLPHMD---------IRLGADDLESSDT------------PAYLSDKLLSEESECEFTKVHLTST 1516

  Fly  1052 IVWAKFNNFRWWPAIILPPTEVPSNILKK----AH---GENDFVVRFFGTHDHGWISRRRVYLYI 1109
            ...|        |:..|||.|.......|    ||   .|.::..........|.:.::   ::|
 Frog  1517 DESA--------PSPPLPPAEKRKGDRSKKPLSAHEFETEKNYETSSAVAMSEGALGKQ---MFI 1570

  Fly  1110 -EGDTGDGHKTKSQL---FRNYTTGVEEASRFLPII-------------KARRQEQDM--ERQSG 1155
             :.|...|.|..:.:   |||  ..:.|.:...|||             :..::|:|:  .::|.
 Frog  1571 GQPDAVSGIKDPAAVPLDFRN--DSLSENTVHEPIIQKVPLKELENQWNEVLKEEEDITKHKKSR 1633

  Fly  1156 NKLHPPPYVKIKTNKAVPPLRFS---------QNLEDLSTC---------------NCLPVDE-- 1194
            |..|...|.:..|   ||...||         ...|:::..               .|:..|.  
 Frog  1634 NSRHNNRYDEFST---VPSPEFSPPRAMFKPRSEFEEMTILYDIWNGGIDDEDIKYMCITYDRLL 1695

  Fly  1195 ----------------HPC----GPE------------AGCL-------------------NRML 1208
                            ||.    .|:            .||.                   ||.|
 Frog  1696 QQDNGMDWLNDTLWVYHPSTSVYSPKKKKRDDGLREHVTGCARSEGYYKIDKKDKLKYLINNRSL 1760

  Fly  1209 FNE-----------CNPE-YCKAGSLCENRMFEQRK-------SPRLEVVYMNERGF-------- 1246
            ..|           ..|: ..:|||   .|..|||:       |...:::..|:..|        
 Frog  1761 TEELPIDTQGKSIPAQPQASTRAGS---ERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLRFC 1822

  Fly  1247 -------GLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPK 1304
                   ||...|||...:.||||||:.|.......|.::.:.:...:.|...|:.|.||||...
 Frog  1823 KSHIHDWGLFAMEPIIADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKC 1887

  Fly  1305 GNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKR 1369
            ||.|||:||||.|||..:..||....::.|::.:.|.||.|:|::|.:.  :.:.|..|.|||:.
 Frog  1888 GNFARFINHSCNPNCYAKVITVESQKKIVIYSKQYINVNEEITYDYKFP--IEDVKIPCLCGAEN 1950

  Fly  1370 CSGEI 1374
            |.|.:
 Frog  1951 CRGTL 1955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 28/197 (14%)
PHD2_NSD 867..932 CDD:277040 16/83 (19%)
PHD3_NSD 933..988 CDD:277041 13/65 (20%)
PHD4_NSD 1001..1041 CDD:277042 5/41 (12%)
WHSC1_related 1047..1141 CDD:99899 21/104 (20%)
AWS 1183..1233 CDD:197795 19/136 (14%)
SET 1234..1354 CDD:214614 43/134 (32%)
setd1bNP_001072649.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
RRM_Set1B 119..211 CDD:240993
RRM <127..304 CDD:223796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..478 21/93 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..637 38/199 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..696 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..1148 39/222 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1341..1386 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1464 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1512..1553 11/48 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1627..1655 9/30 (30%)
N-SET 1669..1807 CDD:288597 20/140 (14%)
SET <1732..1956 CDD:225491 65/229 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1766..1790 5/26 (19%)
SET 1817..1939 CDD:214614 41/123 (33%)
PostSET 1940..1956 CDD:214703 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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