Protein Alignment NSD and Ehmt1

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_006498485.1
• Gene: Ehmt1 / 77683
• MGIID: 1924933
• Length: 1312
• Species: Mus musculus
• Alignment Length: 1562
• Identity: 309/1562 - (19%)
• Similarity: 490/1562 - (31%)
• Gaps: 508/1562 - (32%)

  Fly     7 AHSEIEGDAAHGNVLCNSASDSLTATDEVAAGNDES---VATEGD------------DVEIPRDT 56
            |..|.:.|......|.....|:..|.||.:....|.   :|.:|:            .:..|:.|
Mouse    26 AKQETKQDCCMKTELLREGKDTPMAADEGSTEKQEGETPMAADGETNGSCEKSGDPSHLNAPKHT 90

  Fly    57 NNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPK 121
            ..:|  |...:.|.|.|...|:....|.:.|..:|..|......:.|::......:| :.||..:
Mouse    91 QENT--RASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLN-KPALQGQ 152

  Fly   122 YIGYANANSPTPLSDSDDTIRTTRRRVNQAAAL-NNSSAGETLAHDNASPRTPGGGGGGGGDDSA 185
            .:...|             |.|:....:.|..| ..:|...||   :|.|:||.......|:.||
Mouse   153 PLRTPN-------------ILTSSLPGHAAKTLPGGASKCRTL---SALPQTPTTAPTVPGEGSA 201

  Fly   186 NQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEK 250
            :....|                 |.::|.:           ||.|  |..|.:||:.:.|....|
Mouse   202 DTEDRK-----------------PTASGTD-----------VRVH--RARKTMPKSILGLHAASK 236

  Fly   251 NQQEVDEKSVKTEPID---EEVDRTDEAPTQEA--------QTTAISIKSETEAEHKAAVDVHIK 304
            :.:||.:.....|.|:   .|..|....||..|        |....:.||:|..
Mouse   237 DHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTAC----------- 290

  Fly   305 QEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTE----------VDLKSPPDL 359
                                              |.|.|..|.|.:          |..|....|
Mouse   291 ----------------------------------LPFVLAAAVSRKKKRRMGTYSLVPKKKTKVL 321

  Fly   360 SSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGN 424
            ....:....||.:..:: .|||
Mouse   322 KQRTVIEMFKSITHSTV-GAKG------------------------------------------- 342

  Fly   425 MPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELR--IKHGPKSA 487
                  ..:||::    .:||     ||       |:|    .:.:.|:..:||.  ..||.:.|
Mouse   343 ------EKALDDS----ALHV-----NG-------ESL----EMDSEDEDSDELEDDEDHGAEQA 381

  Fly   488 KYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDV 552
            ........||.    ::::.|         :||..|.....|.               .|::.|.
Mouse   382 AAFPTEDSRTS----KESMSE---------TDRAAKMDGDSEE---------------EQESPDT 418

  Fly   553 GSSLYDSTD--NLHNKQGTQLLAVKRE-RSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSN 614
            |.. .|..|  :|.::...:...:||. :::||:      :|...::|.:.||..:..   .||.
Mouse   419 GED-EDGGDESDLSSESSIKKKFLKRRGKTDSPW------IKPARKRRRRSRKKPSSM---LGSE 473

  Fly   615 SMAVTPSQTETTV--DSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLR 677
            :...:|...|...  ||:.|            || |.::..|.:|..:|.|...|
Mouse   474 ACKSSPGSMEQAALGDSAGY------------ME-VSLDSLDLRVRGILSSQTEN---------- 515

  Fly   678 ELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLS 742
               ..||||  .:.||:      .|:..:...|.|:.|...|...|  :..:...|....|..|.
Mouse   516 ---EGLASG--PDVLGT------DGLQEVPLCSCRMETPKSREIST--LANNQCMATESVDHELG 567

  Fly   743 EPPKT------KKPVNR-PIEEVIEDILQLDSKYLFRGLSRE----PICKYCYQAGSDLVRC--S 794
            ....:      .:|.|: |:..:.||         .||...:    |.|.|...|| :.:.|  .
Mouse   568 RCTNSVVKYELMRPSNKAPLLVLCED---------HRGRMVKHQCCPGCGYFCTAG-NFMECQPE 622

  Fly   795 RTCSSWLHADCLERKVTGAPMPKIGSR----------KALVIPPTSKSPSPDEDHVTADAKEVVA 849
            .:.|...|.||..|....:..|..|..          ||......:.:|. .|..:.|:.:....
Mouse   623 SSISHRFHKDCASRVNNASYCPHCGEEASKAKEVTIAKADTTSTVTLAPG-QEKSLAAEGRADTT 686

  Fly   850 VGTSLVCHECNVGEPEG---------CVICHQVESPA--VPSTPRKEDSSSHTPIEDKLLTCSQP 903
            .|:.       .|.||.         ...|.....||  |..|...........:|..|:.....
Mouse   687 TGSI-------AGAPEDERSQSTAPQAPECFDPAGPAGLVRPTSGLSQGPGKETLESALIALDSE 744

  Fly   904 MCGK-RFHTSCCKYW------------------PQASSSKHSARCPRH---------VCH----- 935
            ...| |||.....:.                  |.......|.|.|.|         :||
Mouse   745 KPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQA 809

  Fly   936 -----TCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH------- 988
                 ||..|..:...:...::.|          ..:...|.||.|       :.|:.
Mouse   810 GANIDTCSEDQRTPLMEAAENNHL----------DAVKYLIKAGAQ-------VDPKDAEGSTCL 857

  Fly   989 NIAKADAHVNVLWCYICVKGGELVCCET----CPI---AVHAHCR----------NIPIKTNESY 1036
            ::|....|.:|:. |:...|...|.|:.    .|:   ..:.|..          :|.|:.||..
Mouse   858 HLAAKKGHYDVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEEN 921

  Fly  1037 ICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPT----------EVPSNILKKAHGEN--DFVV 1089
            ||             :.||.|:.......|:|...          :.|.:|   |..||  |.||
Mouse   922 IC-------------LHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHI---AARENRYDCVV 970

  Fly  1090 RFFGTHDHGWISRRRVYLYIEGDTG-DGHKTKSQLFR--NYTTGVEEASRFLPIIKARRQEQDME 1151
            .|........:..:      ||:|. ......||::.  ..:..:.:::...|:...:...:|:.
Mouse   971 LFLSRDSDVTLKNK------EGETPLQCASLSSQVWSALQMSKALRDSAPDKPVAVEKTVSRDIA 1029

  Fly  1152 R-----------QSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHP-----CG-- 1198
            |           ...::|.|..|..:..|....|:...:|:..|..|.|  ||:..     ||
Mouse  1030 RGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVC--VDDCSSSTCMCGQL 1092

  Fly  1199 -------------PEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVN 1250
                         ||.......|..||| ..|.....|.||:.:.....||::....:.|:|:.:
Mouse  1093 SMRCWYDKDGRLLPEFNMAEPPLIFECN-HACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRS 1156

  Fly  1251 REPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKD---FIIDAGPKGNLARFMN 1312
            .:.|.:|.||.|||||:|:.:|...|.|       ::|.|....||   :.|||...||::||:|
Mouse  1157 LQDIPLGTFVCEYVGELISDSEADVREE-------DSYLFDLDNKDGEVYCIDARFYGNVSRFIN 1214

  Fly  1313 HSCEPNCETQKWTVNCIH------RVGIFAIKDIPVNSELTFNY---LWDDLMNNSKKACFCGAK 1368
            |.||||....:  |...|      |:..|:.:.|....:|.|:|   .||  :.....:|.||:.
Mouse  1215 HHCEPNLVPVR--VFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWD--VKGKLFSCRCGSS 1275

  Fly  1369 RC 1370
            :|
Mouse  1276 KC 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	17/120 (14%)
		PHD2_NSD	867..932	CDD:277040	15/85 (18%)
		PHD3_NSD	933..988	CDD:277041	11/64 (17%)
		PHD4_NSD	1001..1041	CDD:277042	12/56 (21%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	20/109 (18%)
		AWS	1183..1233	CDD:197795	17/69 (25%)
		SET_NSD	1233..1375	CDD:380950	48/150 (32%)
Ehmt1	XP_006498485.1	EHMT_ZBD	530..660	CDD:411018	28/141 (20%)
		ANKYR	734..990	CDD:440430	54/295 (18%)
		ANK repeat	788..817	CDD:293786	6/28 (21%)
		ANK repeat	819..850	CDD:293786	7/47 (15%)
		ANK repeat	852..884	CDD:293786	7/32 (22%)
		ANK repeat	886..917	CDD:293786	4/30 (13%)
		ANK repeat	919..950	CDD:293786	8/43 (19%)
		ANK repeat	952..983	CDD:293786	9/33 (27%)
		SET_EHMT1	1050..1280	CDD:380933	69/242 (29%)