Protein Alignment NSD and NSD2

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Alignment Length: 1455
• Identity: 387/1455 - (26%)
• Similarity: 605/1455 - (41%)
• Gaps: 330/1455 - (22%)

  Fly    88 SQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAA 152
            |.:|:|:..|..  |..:..|:         :|:.:|.||..:|:...:.:.::..::.::  ::
Human     4 SIKQSPLSVQSV--VKCIKMKQ---------APEILGSANGKTPSCEVNRECSVFLSKAQL--SS 55

  Fly   153 ALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSP---------IEKLLIKNGASS 208
            :|......:...|| |.|..|.        |....|.|:.:...         .|...:|...:.
Human    56 SLQEGVMQKFNGHD-ALPFIPA--------DKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTP 111

  Fly   209 PNSTGFEAGSEDLGIRPIVRKHVKRKMKRVP--------KAKVTLELDEKNQQEVDEKSVKTEPI 265
            ||:|..:.||.::.:     |..|..|...|        .:...:...|:|.|:.:.|:.:....
Human   112 PNTTPIKNGSPEIKL-----KITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKR 171

  Fly   266 DEEVDR-TDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEP 329
            ..:.|. .::...:.|..:.||..|:.:...:..|..|:
Human   172 SIKYDSLLEQGLVEAALVSKISSPSDKKVFRRRCVRGHV-------------------------- 210

  Fly   330 KDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQ 394
                          .|:|.....:::|..:...|.....|..|..:....|...:       .|.
Human   211 --------------TLSSEHGHPMRAPARVLGRAEKIPAKKESCPNTGRDKDHLL-------KYN 254

  Fly   395 VGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKP 459
            ||||.|.||..|.:|||||..|||        .|.............|.||:||.|...|.||..
Human   255 VGDLVWSKVSGYPWWPCMVSADPL--------LHSYTKLKGQKKSARQYHVQFFGDAPERAWIFE 311

  Fly   460 ENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKV-VIWRQAIEEAQAMTQIPYSDRLEK 523
            ::|:.|.|...|:.:.:|...:...|:.|.:.:.|...|: ..|...|.:|:....:...:|..|
Human   312 KSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAK 376

  Fly   524 FYQTY-ENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAF 587
            |...| .:.:.||.|..|......:...::..|                ..|..|.:|:|
Human   377 FTFLYVGDQLHLNPQVAKEAGIAAESLGEMAES----------------SGVSEEAAENP----- 420

  Fly   588 SPVKSKNE-----KRAKRRKLSNGTEA-----DTGSNSMAVT------------PSQTETTVDSS 630
               ||..|     ||.:|.||.:..|.     |.|.::...|            |.:.:|||..
Human   421 ---KSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSM- 481

  Fly   631 AYENPEFRQ--LLSAVMEYVMMNR----------SDEKVEKVLLSVVSNIWSLKQIQLRELERD- 682
                |..|:  ..|..:.:...:|          |.|::|::|.|.    |||    |.|.:|.
Human   482 ----PRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQ----WSL----LSEKQRAR 534

  Fly   683 -------LASGEIEEPLGS----------------------------------------SVVGRG 700
                   :|..:.||..|:                                        ::..:.
Human   535 YNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKT 599

  Fly   701 SGVGTIKRL--SNRLMTMMVRRSMTPVVTP------STTPA--------PSEPDRRLSEPPKTKK 749
            :...:.|.:  ::.|.:....::::....|      ::|.|        .|.|...|:|...:..
Human   600 ARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDS 664

  Fly   750 PVNRPIEEVIEDI------LQLDSKYLFRGLS--REPICKYCYQAGSDLVRCSRTCSSWLHADCL 806
            |.:.|.|...|..      :.:.||...||::  :|.:|:.|.:.|| |:.|...|....|..||
Human   665 PGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGS-LLLCEGPCCGAFHLACL 728

  Fly   807 ERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICH 871
                                 ..|:.|   |...|              |.||..| ...|.:|.
Human   729 ---------------------GLSRRP---EGRFT--------------CSECASG-IHSCFVCK 754

  Fly   872 QVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHT 936
            :                |.|.::    .|....|||.:|.:|.|.:|.........|||.|.|.:
Human   755 E----------------SKTDVK----RCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVS 799

  Fly   937 CVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKA----DAHV 997
            |.:.:||......|  |:.:|||||..||....|:.||..::.:.:|||..|..|:.    .|||
Human   800 CHASNPSNPRPSKG--KMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHV 862

  Fly   998 NVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRW 1062
            ||.||::|.|||.|:|||:||.|.|..|.||.: .:.|:.|.:|.:|:...:.:|:|.|..|:||
Human   863 NVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEM-PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRW 926

  Fly  1063 WPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTG---DGHKTKSQLF 1124
            |||.:..|..||.||.|..|...:|.|.|||:.|:.|..:.||:.|:|||.|   .|.:...::|
Human   927 WPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVF 991

  Fly  1125 RNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLR-FSQNLEDLSTCN 1188
            :|.....|...|.:.:.:..|:.|:.||:      ||||..||.||....:: ::.::.::..||
Human   992 KNALQEAEARFREIKLQREARETQESERK------PPPYKHIKVNKPYGKVQIYTADISEIPKCN 1050

  Fly  1189 CLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREP 1253
            |.|.||:|||.::.||||||..||:|:.|.||..|:|:.|.:|:.|..:::..:.:|:|||.:..
Human  1051 CKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRD 1115

  Fly  1254 IAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPN 1318
            |..|:||.|||||:|:..|...|::....:...::|.|.::||.|||||||||.:|||||||:||
Human  1116 IRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPN 1180

  Fly  1319 CETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK---- 1379
            |||.|||||...|||:||:.|||..:||||||.. |.:.|.|..|.|||..|||.:|.:.|
Human  1181 CETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNL-DCLGNEKTVCRCGASNCSGFLGDRPKTSTT 1244

  Fly  1380 ---DDAVKAHAKLKQMRRAKASAVR 1401
               ::..|...|..:.||||....|
Human  1245 LSSEEKGKKTKKKTRRRRAKGEGKR 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	38/119 (32%)
		PHD2_NSD	867..932	CDD:277040	15/64 (23%)
		PHD3_NSD	933..988	CDD:277041	19/54 (35%)
		PHD4_NSD	1001..1041	CDD:277042	19/39 (49%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	35/97 (36%)
		AWS	1183..1233	CDD:197795	25/49 (51%)
		SET_NSD	1233..1375	CDD:380950	71/141 (50%)
NSD2	NP_001427822.1	None