DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and Nsd2

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_001178481.2 Gene:Nsd2 / 680537 RGDID:1307955 Length:1365 Species:Rattus norvegicus


Alignment Length:1450 Identity:385/1450 - (26%)
Similarity:598/1450 - (41%) Gaps:353/1450 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 SQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVN--- 149
            |.|::|:..|:.  |..:..|:         :|:.:|.||.             :|....||   
  Rat     4 SIRKSPLSVQKV--VKCMKMKQ---------APEILGSANG-------------KTQNCEVNHEC 44

  Fly   150 ----QAAALNNSSAGETL----AHDNASPRTPGG----------GGGGGGDDSANQLLSKTYMSP 196
                ..|.|:||.....:    .|| |.|..|..          .|..|..|:  :|..:|..  
  Rat    45 SVFLSKAQLSNSLQEGVMQKFNGHD-ALPFLPAEKLKDLTSCVFNGEPGAHDT--KLCFETQE-- 104

  Fly   197 IEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVK 261
                 :|...:.||:|..:.||                    |:.|:.:.....|.:.:.|.|: 
  Rat   105 -----VKGIGTPPNTTPIKNGS--------------------PEIKLKITKTYMNGKPLFESSI- 143

  Fly   262 TEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVIT 326
                      ..:.....:|:.....||:.:...        .::.:|:.|.:            
  Rat   144 ----------CGDGAADMSQSEENGQKSDNKTRR--------NRKRSIKYDSL------------ 178

  Fly   327 EEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWP 391
                 ||:...|.|....::|..  |.|.|           :|..|..:....:.|.:       
  Rat   179 -----LEQGLVEAALVSKISSPE--DKKIP-----------VKKESCPNSGRDRDLLL------- 218

  Fly   392 TYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQ-RSSLDNANVPIQVHVRFFADNGRRN 455
            .|.||||.|.||..|.:|||||..|||      :.:|.: :....:|.   |.||:||.|...|.
  Rat   219 KYNVGDLVWSKVSGYPWWPCMVSADPL------LHNHTKLKGQKKSAR---QYHVQFFGDAPERA 274

  Fly   456 WIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKV-VIWRQAIEEAQAMTQIPYSD 519
            ||..::|:.|.|.:.|:.:.:|...:...|:.|.:.:.|...:: ..|...|.:|:....:...:
  Rat   275 WIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSVEE 339

  Fly   520 RLEKFYQTY-ENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPF 583
            |..||...| .:.:.||.|..|.....   |..:|..:..|..|             .|.:..|.
  Rat   340 RKAKFTFLYVGDQLRLNPQVAKEAGIA---TEPLGEMVDSSVAN-------------EEAAVDPG 388

  Fly   584 SPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLL------- 641
            :.....:..|..:||||...:...|.|.|:...  ||.:...........:|..|:..       
  Rat   389 TMREEDIPVKRRRRAKRSSSAENQEGDPGTEKS--TPPKMADAEPKRGVGSPAGRKRSTGSASRS 451

  Fly   642 ----SAVMEYVMMNR------------SDEKVEKVLLSVVSNIWSLKQIQLRELERD-------- 682
                ||....|...:            |:|::|::|    .:.||:    |.|.::.        
  Rat   452 RKGDSAAQFLVFCQKHRDEVVAEHPDASEEEIEELL----GSQWSM----LNEKQKARYNTKFSL 508

  Fly   683 LASGEIEEPLGSS-------------------------------------------VVGRGSGVG 704
            :.|.:.||..|::                                           ...|.|...
  Rat   509 MISAQSEEDSGNTSGKKRTHTKRTDDPPEDVDVEDAPRKRLRTDKHSLRKRETITDKTARTSSYK 573

  Fly   705 TIKRLSNRLMTMMVRRSMTPVVTP-------------------STTPAPSEPDRRLSEPPKTKKP 750
            .|:..|: |.:....::::....|                   |::|:.|..:..:|:.| ..:|
  Rat   574 AIEAASS-LKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTENEVSDNP-GDEP 636

  Fly   751 VNRPIEEVIEDILQ--LDSKYLFRGLS--REPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVT 811
            ...|.|...|...:  :.||...||::  :|.:|:.|.:.|| |:.|...|....|..||     
  Rat   637 SESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGS-LLLCEGPCCGAFHLACL----- 695

  Fly   812 GAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESP 876
                            ..|:.|   |...|              |.||..| ...|.:|      
  Rat   696 ----------------GLSQRP---EGRFT--------------CTECASG-IHSCFVC------ 720

  Fly   877 AVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDD 941
                   ||...       ::..|....|||.:|.:|.|.:|.........|||.|.|.:|.:.:
  Rat   721 -------KESKM-------EVKRCMVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASN 771

  Fly   942 PSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKA----DAHVNVLWC 1002
            ||......|  |:.:|||||..||....|:.||..::.:.:|||..|..|:.    ..||||.||
  Rat   772 PSNPRPSKG--KMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWC 834

  Fly  1003 YICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAII 1067
            ::|.|||.|:|||.||.|.|..|.:|.: .:.|:.|.:|.:|:...:.:|:|.|..|:|||||.:
  Rat   835 FVCSKGGSLLCCEACPAAFHPDCLSIEM-PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEV 898

  Fly  1068 LPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVE 1132
            ..|..||.||.|..|...:|.|.|||:.|:.|..:.||:.|:|||.|..::....:.|.:...::
  Rat   899 CHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQ 963

  Fly  1133 EA-SRF--LPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLR-FSQNLEDLSTCNCLPVD 1193
            || :||  :.:.:..|:.|:.||:      ||||..||.||....:: ::.::.::..|||.|.|
  Rat   964 EAEARFNEIKLQREARETQESERK------PPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTD 1022

  Fly  1194 EHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGD 1258
            |:|||.::.||||||..||:|:.|.||..|:|:.|.:|:.|..:::..:.:|:|||.:..|..|:
  Rat  1023 ENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGE 1087

  Fly  1259 FVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQK 1323
            ||.|||||:|:..|...|::....:...::|.|.::||.|||||||||.:|||||||:|||||.|
  Rat  1088 FVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLK 1152

  Fly  1324 WTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK-------DD 1381
            ||||...|||:||:.|||..:||||||.. |.:.|.|..|.|||..|||.:|.:.|       ::
  Rat  1153 WTVNGDTRVGLFAVCDIPAGTELTFNYNL-DCLGNEKTVCRCGASNCSGFLGDRPKTSTSLSSEE 1216

  Fly  1382 AVKAHAKLKQMRRAKASAVR 1401
            ..|...|..:.||||....|
  Rat  1217 KSKKAKKKTRRRRAKGEGKR 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 38/118 (32%)
PHD2_NSD 867..932 CDD:277040 15/64 (23%)
PHD3_NSD 933..988 CDD:277041 19/54 (35%)
PHD4_NSD 1001..1041 CDD:277042 18/39 (46%)
WHSC1_related 1047..1141 CDD:99899 35/96 (36%)
AWS 1183..1233 CDD:197795 25/49 (51%)
SET 1234..1354 CDD:214614 61/119 (51%)
Nsd2NP_001178481.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 131 1.000 Domainoid score I5026
eggNOG 1 0.900 - - E2759_KOG1081
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 492 1.000 Inparanoid score I1355
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D38976at33208
OrthoFinder 1 1.000 - - FOG0001511
OrthoInspector 1 1.000 - - otm44534
orthoMCL 1 0.900 - - OOG6_102558
Panther 1 1.100 - - O PTHR22884
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X847
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.830

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