DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and Suv39h2

DIOPT Version :10

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_073561.2 Gene:Suv39h2 / 64707 MGIID:1890396 Length:477 Species:Mus musculus


Alignment Length:560 Identity:125/560 - (22%)
Similarity:196/560 - (35%) Gaps:159/560 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   870 CHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVC 934
            ||:  :|..|..|:...::.....|......|:|..|:|          :|.|.:..:..||   
Mouse    17 CHR--APGPPPRPKARRTARRRRAETLTARRSRPSAGER----------RAGSQRAWSGAPR--- 66

  Fly   935 HTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSK--------CIPAGTQMLNTTN----IICPR 987
             ..|..|...:    |:...|.||.|..:...|.:        |...|....|..|    .:|. 
Mouse    67 -AAVFGDECAR----GALFKAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCD- 125

  Fly   988 HNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEI 1052
            :.:||...:..|.|     ||.                   |..||                   
Mouse   126 YKVAKGVEYYLVKW-----KGW-------------------PDSTN------------------- 147

  Fly  1053 VWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGH 1117
            .|....|.|           .|.            ::|.|......::::.|....:..      
Mouse   148 TWEPLRNLR-----------CPQ------------LLRQFSDDKKTYLAQERKCKAVNS------ 183

  Fly  1118 KTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNK----------LHPPPYVKIKTNKAV 1172
            |:.......|.  |::|.:.:.:   :|.:..:.|:..:|          |..||......|:..
Mouse   184 KSLQPAIAEYI--VQKAKQRIAL---QRWQDYLNRRKNHKGMIFVENTVDLEGPPLDFYYINEYR 243

  Fly  1173 PPLRFSQNLEDLSTCNCLPVDEHPCGP-EAGCLNRMLFN--------------ECNPEYCKAGSL 1222
            |....|.|.|....|:|.......|.| |||.:  :.:|              |||.. |:.|..
Mouse   244 PAPGISINSEATFGCSCTDCFFDKCCPAEAGVV--LAYNKKQQIKIQPGTPIYECNSR-CRCGPE 305

  Fly  1223 CENRMFEQRKSPRLEVV-YMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDE 1286
            |.||:.::.....|.:. ..|..|:|:.....|....||:|||||||...|.:|| .|...::..
Mouse   306 CPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERR-GQFYDNKGI 369

  Fly  1287 NYYF-LGVEKD-FIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIH----RVGIFAIKDIPVNSE 1345
            .|.| |..|.| |.:||...||::.|:||||:||.:.....::.:.    |:.:|:.:.|....|
Mouse   370 TYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEE 434

  Fly  1346 LTFNYLW-------DDLMNNS------KKACFCGAKRCSG 1372
            |||:|..       .|.:::|      :..|.|||:.|.|
Mouse   435 LTFDYQMKGSGEASSDSIDHSPAKKRVRTQCKCGAETCRG 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 PWWP_NSD_rpt1 395..514 CDD:438972
PHD2_NSD 867..932 CDD:277040 13/61 (21%)
PHD3_NSD 933..988 CDD:277041 13/66 (20%)
PHD4_NSD 1001..1041 CDD:277042 6/39 (15%)
PWWP_NSD_rpt2 1048..1143 CDD:438963 11/94 (12%)
AWS 1183..1233 CDD:197795 16/64 (25%)
SET_NSD 1233..1375 CDD:380950 51/160 (32%)
Suv39h2NP_073561.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 12/53 (23%)
CD_SUV39H1_like 118..166 CDD:349289 16/114 (14%)
SET_SUV39H2 234..476 CDD:380930 72/245 (29%)
Blue background indicates that the domain is not in the aligned region.

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