Protein Alignment NSD and ehmt2

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_001428432.1
• Gene: ehmt2 / 569250
• ZFINID: ZDB-GENE-010501-6
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1411
• Identity: 276/1411 - (19%)
• Similarity: 443/1411 - (31%)
• Gaps: 545/1411 - (38%)

  Fly   289 SETEAEHKAAVDVHIK---QEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTE 350
            |.:::.|:..|:..:|   .||                 :|....|...||....|       |.
Zfish    15 SSSQSSHEVEVNPAVKGKQMED-----------------LTGRQDDGRPSTSTKTF-------TG 55

  Fly   351 VDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCP 415
            |..||    ||.:.::|:.|.||.|..|.:....|..||..|
Zfish    56 VINKS----SSPSSSSSLSSSSSSSSASGRAKMSVCGPGSKT----------------------- 93

  Fly   416 DPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNW-------IKPENLLTFA------- 466
                      ||....|| .:|..|.:||      ..|:..       |||...::.|
Zfish    94 ----------PSSSSSSS-SSAGPPAKVH------RARKTMNRPPLPQIKPVESISPAAAEKPAG 141

  Fly   467 GLKAFDD-----MREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQ 526
            |.|...|     .:..|.:...|.....:.:.|:....:....|:.:|
Zfish   142 GEKPDADTVVKKRKAGLDVSATPSGTPEKVLKPQTEPPMTASPAVGKA----------------- 189

  Fly   527 TYENVVTLNRQKRKRTKYMMQDTSDVGSS-----LYDS--------TDNLHNK------QGTQLL 572
              |.|.|..:....|   .|:|..:....     ||:|        :|:..::      .|...|
Zfish   190 --EPVATATKDSHSR---WMEDLDEEADEEDFHLLYNSYCGDDVIYSDSKSDEGMTEEPMGAGHL 249

  Fly   573 AVKRERSESPFSPAFSPVKSKNEKRAKRR--------KLSNGTEADT--GSNSMAVTPSQTETT- 626
            :.....|:.|. ||:....|:.|:...:|        :.:.|.|.||  |:.|.:|....|:.|
Zfish   250 SDHSSSSDPPL-PAYKRNSSEREENTWKRQGKGKARDRAAAGGEQDTEKGAESASVAVGSTDYTE 313

  Fly   627 -----VDSSA-------------YENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQ 673
                 :|.||             .|..|...|.|..||...::.|..:..:..:::.|
Zfish   314 VPLDSLDISAADSLSHADGSDAETERLEELPLCSCRMEAPRLDSSSVRSSRTCMAIQS------- 371

  Fly   674 IQLRELERDLASGEIEEPLG-SSVVGRGSGVGTIKRLSNRLMTM-------MVR----------- 719
                      .:||:   :| ::|:.:|..:....|:|  ||.:       ||:
Zfish   372 ----------INGEL---VGCTNVIMKGETMRPSSRVS--LMVLCETHRSHMVKHHCCPGCGYFC 421

  Fly   720 -------------------RSMTPVV-TPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQ 764
                               ||...|: :..:..|....|.:.:||..:
Zfish   422 LSGTFLECCPDVHITHRFHRSCVSVLGSGRSRGAAGGSDDQWAEPTSS----------------- 469

  Fly   765 LDSKYLFRGLSREPI------CKYCYQ----------------AGSDLVRCSRTCSS----WLHA 803
                    |.||..:      |.:|.:                |||.:|..|.:.::    ..|.
Zfish   470 --------GRSRGTVGVGLLFCPHCGEDASEARTVSIPPEAPPAGSHVVTASASSTTASNHTQHT 526

  Fly   804 DCLERKVT---GAPMPKIG-SRKA--LVIPPT--SKSPSPDEDHVTADAKEVVAVGTSLVCHECN 860
            ....|:.|   .|.|...| :||.  |...||  :.:.|.:||.|......|.:||.|||.
Zfish   527 PQTHRRTTDNLNARMRCRGDARKGAELQSQPTNGAAAGSGEEDVVAVGDGGVDSVGPSLVL---- 587

  Fly   861 VGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGK-RFHTSCCKYWPQA---- 920
               |.|..:|    ..|:|:..|:      ..::..:||.......| |||..  :.:|.|
Zfish   588 ---PNGKPVC----PSALPAGDRR------AALQRAILTQDSERRKKLRFHPR--QLYPAAKQGE 637

  Fly   921 ----------------SSSKHSARCPRH---------VCHTCVSDDPSGKFQQLGSSKLA--KCV 958
                            .|...:.||..|         :|:..|         |.|:...|  |.:
Zfish   638 AQRVLLMLMEGMDPSYQSDSQNRRCALHAAAQRGLLEICYLLV---------QAGAKVDAQDKSL 693

  Fly   959 RCP---------------------ATYHQ-------LSKCIPAGT-----QMLNTTNIICPRHNI 990
            |.|                     ..||.       |......|.     .:|:|..:..   |.
Zfish   694 RTPLLEAIVNNHVDVVKYLIQSGACVYHAEDDGSTGLHHAAKLGNLEVVMLLLSTGQVDI---NA 755

  Fly   991 AKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCR----------NIPIKTNESYICEECESGR 1045
            ..:.....|:|.                 |.|.|..          ::.::..|..:|
Zfish   756 QDSGGWTPVIWA-----------------AEHRHIEVIRALLNRGADVTLRDKEMNVC------- 796

  Fly  1046 LPLYGEIVWAKFNNFRWWPAIIL----PPTEV------PSNILKKAHGENDFVVRFFGTHDHGWI 1100
                  :.||.|........::|    |.:.|      |.:|..: .|.:|.|..|..
Zfish   797 ------LHWASFAGSAEIAELVLNAGCPLSSVNVHGDTPLHISAR-EGYSDCVTLFLS------- 847

  Fly  1101 SRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKL------- 1158
              |...:.|....||   |...|.|..|          |:..|.:..:.:.|...|::
Zfish   848 --RGADIDIVNKEGD---TPLSLARGET----------PVWVALQINRKLRRGIANRIVRTERII 897

  Fly  1159 -----------------------HPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPE 1200
                                   .|..|..|..|.....:...:|:..|..|:|  .|:  |. .
Zfish   898 CSDVAQGYENVPIPCVNGVDDEGCPSDYKYIAENCETSAMNIDRNITHLQHCSC--TDD--CS-S 957

  Fly  1201 AGCL-------------NRML--FN--------ECNPEYCKAGSLCENRMFEQRKSPRLEVVYMN 1242
            :.||             :|:|  ||        |||.. |.....|:||:.:.....||::....
Zfish   958 SNCLCGQLSIRCWYDKDHRLLQEFNKIEPPLIFECNMA-CSCHKTCKNRVVQAGIKVRLQLYRTE 1021

  Fly  1243 ERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKD---FIIDAGPK 1304
            :.|:|:...:.|..|.|:.|||||:|:.||...|       .|::|.|....||   :.|||...
Zfish  1022 KMGWGVRALQDIPQGSFICEYVGELISDAEADVR-------EDDSYLFDLDNKDGEVYCIDARYY 1079

  Fly  1305 GNLARFMNHSCEPNCETQKWTVNCIH------RVGIFAIKDIPVNSELTFNY---LWDDLMNNSK 1360
            ||::||:||.|:||....:  |..:|      |:..|:.:||....||.|:|   .||  :.:..
Zfish  1080 GNISRFINHLCDPNIIPVR--VFMLHQDLRFPRIAFFSSRDIFTGQELGFDYGDRFWD--IKSKY 1140

  Fly  1361 KACFCGAKRCSGEIGGKLKDDAVKAHAKLKQMRRAKASAVRIHVKP 1406
            ..|.||:::|             |..|:...:.:::.:.:.:.|:|
Zfish  1141 FTCQCGSEKC-------------KHSAEAIALEQSRLARLEVCVEP 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	21/137 (15%)
		PHD2_NSD	867..932	CDD:277040	15/85 (18%)
		PHD3_NSD	933..988	CDD:277041	14/89 (16%)
		PHD4_NSD	1001..1041	CDD:277042	6/49 (12%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	21/104 (20%)
		AWS	1183..1233	CDD:197795	18/72 (25%)
		SET_NSD	1233..1375	CDD:380950	49/153 (32%)
ehmt2	NP_001428432.1	None