Protein Alignment NSD and kmt2cb

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_009296384.1
• Gene: kmt2cb / 568162
• ZFINID: ZDB-GENE-070705-340
• Length: 4892
• Species: Danio rerio
• Alignment Length: 1540
• Identity: 271/1540 - (17%)
• Similarity: 495/1540 - (32%)
• Gaps: 453/1540 - (29%)

  Fly     3 LSTDAHSEIEGDAAHGNVLCNSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDK 67
            :|:..|||:|...:.|:  |....:|       |.|::|.......::::.:       |...|.
Zfish  3629 MSSQPHSELERQLSEGS--CGGGPES-------AMGHEEMHDRILSNIKLEK-------VEANDC 3677

  Fly    68 PGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPT 132
            .|..|:                       ..:.|:.||..:|:::          :.:.::.||
Zfish  3678 HGHKPI-----------------------DMEIRIGMVKVEREIM----------LHHPSSQSP- 3708

  Fly   133 PLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPI 197
                              |.:.......|.|.|...:.|||  ........|.:.|.|:...|..
Zfish  3709 ------------------ANSSKEEGGNELLKHLLKNKRTP--PHALPHQRSEDSLRSEEEGSTE 3753

  Fly   198 EKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELD------EKNQQEVD 256
            .|...:..:.....|..::..:|.....|:....|::.||.||:.     |      :|.::|.|
Zfish  3754 SKAFFRQNSMDSTGTFSDSNHQDFPGPLILEDKKKQRNKRTPKSG-----DRPAPRCKKRKKEED 3813

  Fly   257 EKSVKTEPIDEEVDRTDEAPTQEAQTTAISIK----------------SETEAEHK-------AA 298
            |........|..:     .|.::...:.:.:.                .:.:.|::       |:
Zfish  3814 ESQAVYSSTDPMI-----TPLKQQHLSLLPLMEPLVGVNFAHLMPYGGGQLDGENRLSGTFGSAS 3873

  Fly   299 VD--------VHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEK------STEELAFALPLASST 349
            :|        :..||.     ::.|.|....|:..|..|...:|      :|||||....|.:..
Zfish  3874 LDGVSDYYSQLIYKQN-----NLSNPPTPPASLPPTPPPVARQKLLNGFATTEELARKGGLIAGH 3933

  Fly   350 EV---------DLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFS 405
            :|         :.|:..:|.:.|||   :.|.:|::.::          .||
Zfish  3934 DVTKGLLARPLEFKAEEELLAQALA---QGPKTVNVPAS----------LPT------------- 3972

  Fly   406 YCFWPCMVCPDPLGQIVGNMPSHPQRSSL------DNANVPIQVHVRFFADNGRRNWIKPENLLT 464
                                |.|..:..|      ::.|.|..     |..:.     .||:::.
Zfish  3973 --------------------PPHNNQEELRGQEHCEDRNTPDS-----FVPSS-----SPESVVG 4007

  Fly   465 FAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYE 529
            .. :..:.|:.   .:|..|.|.....::|   ...::|....:.|.:...|.|...:..:::.:
Zfish  4008 ME-ISRYPDLS---LVKEEPPSPAMSPVIP---MFPVFRDKDVKLQEVKTEPSSVFFDSSFRSVQ 4065

  Fly   530 N-----VVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVK----RERSESPFSP 585
            |     :|::....:...   .::.:||.:::.|            |:.||    .|.|..| ..
Zfish  4066 NGSNTGLVSIAIMLKPAA---AENITDVVAAIAD------------LIRVKIPSSYEVSSGP-GG 4114

  Fly   586 AFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYEN----PEFRQLLSAVME 646
            :|..:|:..:.:.....|.||..|...:....:........:....|.:    |..:|......:
Zfish  4115 SFGAIKTSVDPQCLASALPNGPRALRQAPQHLLLQHNHNKNIGGEQYRDGQVRPGSKQQWCQHCK 4179

  Fly   647 YVMMNR------SDEKV---EKVLLSVVSNIWSLKQIQLRELERDLASGEIEE----PLGSSVVG 698
            .|::.:      .||:|   |..|.|....::......:.......::|..:.    ||.|....
Zfish  4180 VVVLGKGVRKITKDEEVKPQESRLCSDGGLVFCSHSCLILHSSSSQSNGNADNKASVPLLSESAL 4244

  Fly   699 RGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLS---EPPKTKKPVNRPIEEVIE 760
            :.|......:.||.:.::.|.      ......|.||.|...|.   .|.|..|..::| ..:.|
Zfish  4245 KQSFSKVQHQYSNNMSSLDVH------CLAQLQPKPSSPAPYLHMAFAPAKAIKTESKP-RSISE 4302

  Fly   761 DILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLE----RKVT-GAPMPKIGS 820
            ..|::..|...|                  :........|.|....:    ||.| ...|||:
Zfish  4303 GHLKVTVKLKPR------------------LHSHLEDKQWHHGKRWKGLRWRKWTIDIAMPKV-- 4347

  Fly   821 RKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHEC-NVGEPEGCVICHQVESPAVPSTPRK 884
                       :|...|..:....|::.   |||  ..| .:.:...|..|.|:.........|.
Zfish  4348 -----------APQSSESELEERLKQLT---TSL--RPCLTIRDQRRCCFCQQIGDGMTDGPARL 4396

  Fly   885 EDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSA---------RCPRHVCHTCVSD 940
            .:....|.:                |.:|..:..:...::..|         |....||..|
Zfish  4397 LNLDLDTWV----------------HLNCALWSSEVYETQAGALINVGLARQRGQTVVCAFC--- 4442

  Fly   941 DPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIIC----PRHNIAKADAHV-NVL 1000
                  |:||::.....:||...|| .:..:.||........::|    ||...|.|..|| :.|
Zfish  4443 ------QRLGATSGCHRLRCLNIYH-FTCALQAGCTFFKDKTMLCHQHRPRGAGAAAGLHVEHQL 4500

  Fly  1001 WCYICVKGGELVCCETCPIAVHAHCRNIPIKTNE----SYICEECESGRLPLYGEIVWAKFNNFR 1061
            .|:                   :..|.:.::.:|    :...::.|.|.....|.:::.....
Zfish  4501 RCF-------------------SVFRRVYVQRDELRQLAAAVQQPERGHTFRVGSLLFHAMGQ-- 4544

  Fly  1062 WWPAIILPPTEVPSNILKKAHGENDF------VVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK 1120
                  |||..:|:     .|.....      ..|.:.:..||. .|.|....:|...|....:.
Zfish  4545 ------LPPALMPT-----FHSSTAIFPPGYEATRLYWSMRHGQ-KRCRYVCSVEEHEGRAEFSI 4597

  Fly  1121 SQLFRNY---------TTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIK-----TNKA 1171
            ..:.:.|         ..||.|  :.|..:..||.|..|.|..      |.|:|.:     |..|
Zfish  4598 RVIEQGYEDLVLTDTSAKGVWE--KVLGPVAERRAETGMLRLF------PIYLKGEDLFGLTISA 4654

  Fly  1172 VPPLRFSQNLEDLSTCN------------CLPVDEHPCGPEAGCL------------------NR 1206
            |  .|.:::|..:..|:            .||:..:..|.....|                  :|
Zfish  4655 V--TRIAESLPGVEACSRYRFRYGRNPLLVLPLSMNSSGSARSELQTYPQHERVKILSSWPRISR 4717

  Fly  1207 MLFNECNPEYCKAGSLCENRMFEQRKSPR-----------LEVVYMNERGFGLVNREPIAVGDFV 1260
            .:.|..    ..|.:...::.|...||.:           :.:.:...:|.||.....|.....|
Zfish  4718 CIQNST----VAASASSHSKHFVHSKSSQYRRLASDWKSNVYLAHSRIQGLGLFAARAIEKQTMV 4778

  Fly  1261 IEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWT 1325
            |||:|::: ..|...|.|...:.::...|...::.:.:|||...|:.||::||||.|||..:..|
Zfish  4779 IEYMGDIL-RTEVAMRRELLYKAKNRPAYMFCIDSERVIDATNSGSPARYINHSCSPNCVAEVVT 4842

  Fly  1326 VNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRC 1370
            ....:::.|.|...|....||.::|....:.:.||..|.|||.:|
Zfish  4843 FERGYKIIISAACRIERGEELCYDYKLTPVNDQSKIPCHCGAAKC 4887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	15/124 (12%)
		PHD2_NSD	867..932	CDD:277040	9/73 (12%)
		PHD3_NSD	933..988	CDD:277041	14/58 (24%)
		PHD4_NSD	1001..1041	CDD:277042	3/43 (7%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	18/109 (17%)
		AWS	1183..1233	CDD:197795	9/79 (11%)
		SET_NSD	1233..1375	CDD:380950	41/149 (28%)
kmt2cb	XP_009296384.1	PHD_SF	232..319	CDD:473978
		PHD1_KMT2C_like	332..377	CDD:276984
		PHD2_KMT2C	379..424	CDD:277069
		PHD3_KMT2C	459..507	CDD:276986
		PHD_SF	947..1003	CDD:473978
		PHD5_KMT2C_like	1004..1050	CDD:276988
		PHD_SF	1081..1131	CDD:473978
		HMG-box_KMT2C	1672..1752	CDD:438835
		PHA03247	<1871..2385	CDD:223021
		GBP_C	<3168..3268	CDD:460721
		PHA03247	<3273..3602	CDD:223021
		PHD_SF	4379..4483	CDD:473978	22/129 (17%)
		FYRN	4535..4586	CDD:461787	11/64 (17%)
		FYRC	4595..4676	CDD:461788	19/90 (21%)
		SET	4739..4891	CDD:394802	42/150 (28%)