DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and setd1ba

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_001038599.2 Gene:setd1ba / 567970 ZFINID:ZDB-GENE-050309-289 Length:1844 Species:Danio rerio


Alignment Length:1649 Identity:319/1649 - (19%)
Similarity:526/1649 - (31%) Gaps:573/1649 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 PRDTNNSTPVRLLDKPGQNPVQN-----GAQPAAEESELESQRQTPVQKQQQ----QRVSM---- 104
            |..:.:..|||  |:|...|:..     ..||....|.......:|.|:.::    .|:.|    
Zfish   441 PPPSTDFLPVR--DRPTTPPIPEPPPAPETQPTTPPSSTPEPCPSPTQESERNSLDSRIEMLLKP 503

  Fly   105 -VNRKRD-----------LINLQSALS---------PKYIGYANANSPTPLSDS--DDTIRTTRR 146
             :|.:.|           :.:..|.||         |...|..:. |||||.||  |:.||.|  
Zfish   504 FLNERGDSDAEVRMDGSPISSSSSQLSPIPPQRPSRPSSTGLEDI-SPTPLPDSEDDEPIRGT-- 565

  Fly   147 RVNQAAALNNS-SAGETLAHDNA---SPRTP----GGGGGGGGDDSANQLLSKTYM--SPI---- 197
                |:.|.|| ....|..|..:   .|||.    ..|....|:|..   :|...|  :||    
Zfish   566 ----ASLLANSRGMSPTNMHSKSCVGEPRTAIDKMDTGHQSSGEDME---ISDDEMPGTPIASGD 623

  Fly   198 -EKLLIKNGASS---------------PNSTGFEAGSEDLGIRPIVRKHVKR------------- 233
             :|.::.|.|.|               |::.||          |:...|:..             
Zfish   624 CDKNIVVNSALSLIQTIPMPPPGFPPLPHAAGF----------PLPPHHLPHHSTVSHLPSHHPM 678

  Fly   234 ----------------------KMKRVPKAKVTLELDEKNQQE---------------------- 254
                                  ::.::|....|..|....|.:                      
Zfish   679 LHPLHSYGMMHFLPVDLLSSLPQLLQMPFQMQTQMLSRMAQSQHPYAYPYPAPSANPAAMPFGGP 743

  Fly   255 VDEKSVKTEPIDEEVDRTDEAPTQEAQTTAI---SIKSETEAEHKAAVD----VHIKQEDTI-RL 311
            ....||.:.|.|....:....|:......|:   ..:.:.|..|||.:|    ..:|:...| :.
Zfish   744 YPPLSVVSAPADTLHGQPWPLPSMPQFNPAVPPPGYEPQKEDPHKATIDGVLMAIVKELKAIMKK 808

  Fly   312 DIVNNPVESTSI--------------------VITEEPKDLEKST----------------EELA 340
            |:....||..:.                    |.|.|.||.||..                |.|.
Zfish   809 DLNRKMVEVVAFRKFDEWWDKQELSAKATLTPVKTGEGKDEEKERAKPKETMSSHLPWNKGEGLG 873

  Fly   341 F------------ALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTY 393
            |            .||   |.:|..|.||:.:||:....:: ||:...|..:...        :.
Zfish   874 FEGMGLGIGLRGIRLP---SFKVKRKQPPEPTSTSDNKRVR-PSTPVDDELEDEE--------SE 926

  Fly   394 QVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIK 458
            ::|.....:|            ||.|......|:.|  ..||:.           .:.......|
Zfish   927 RMGRTDGSRV------------DPAGSSSKRRPARP--LELDSE-----------GEEEEETSGK 966

  Fly   459 PENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEK 523
            .|:.|:        |..||                                      |..|..|:
Zfish   967 EESSLS--------DHEEE--------------------------------------PVDDASER 985

  Fly   524 FYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFS 588
            .....:    |..:..|:::....::....||..:::.:..:|.|:.     ...|||......|
Zfish   986 LSSGKD----LEEEDEKKSESHSSESESSDSSDDEASSSSSSKSGSD-----SSGSESSSDYESS 1041

  Fly   589 PVKSKNEKRAKRRKLSNGTEAD------TGSNSMAVTPSQTETTVDSSAYENP-------EFRQL 640
            ..:.:.|:..:.|.:....|.|      |.|::.:.:.|..|..|:..|...|       |..:|
Zfish  1042 SEEEEEEEEEEERIVGMDDEEDVDARTSTSSSTTSTSSSDEEEVVEVKAPSTPTGPPPEEEPNEL 1106

  Fly   641 --LSAVMEY------VMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSS-- 695
              |.||.|.      .|::....|||:|...      |.|.:...||:.||   |::.|:..:  
Zfish  1107 GRLEAVDEAEIDHKPSMVSLIKTKVEEVRPP------SPKGLPADELDVDL---EVKIPVPKTEA 1162

  Fly   696 ---VVGR-------GSGVGTIKRLSNRLMTMMVRRSMTP-----------VVTPSTTPAPS---- 735
               .||.       ||...:.:....::.|....|  ||           ...|.:.|.||    
Zfish  1163 SLEEVGNLRPPTPTGSFADSDQDTRPKIPTEDFPR--TPGHEGPVPLESETTVPRSLPTPSMHLP 1225

  Fly   736 -----EPD-RRLSEPPKT--KKPV--NRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDL 790
                 .|| :.|..||:|  ..||  ..|.||               .:.|.|        |.||
Zfish  1226 LPPSHVPDPQSLLPPPETLPDMPVRGRLPTEE---------------DIPRTP--------GRDL 1267

  Fly   791 VRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLV 855
            :..:|                  .:.|:.|...:.:.|.|.:|               ..|.||.
Zfish  1268 MDRAR------------------GLGKLQSTDTVPVTPGSDTP---------------LTGNSLS 1299

  Fly   856 CHECNVGEPEGCVICHQVESPAVPSTPRKE--------DS---SSHTPIEDKL---LTCSQPMCG 906
            .... :|.|........|.|..:|.||.::        ||   |:..||..|.   :...:|:  
Zfish  1300 SPHI-LGSPFSYPAQSPVLSAGIPRTPGRDLTFAPAFPDSAGLSAGLPIHRKASSEILEEKPL-- 1361

  Fly   907 KRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCI 971
              |........||||...::|..|........:..|.......||.        ||:   :....
Zfish  1362 --FKEPLLSASPQASLPNNAASSPFPGPPLPTASLPEPALPPQGSP--------PAS---IENSF 1413

  Fly   972 PAGTQMLNTTNIICP--------RHNIAKADAHVNVLWCYICVKGGE-----LVCCETCP-IAVH 1022
            ||..:.|....|..|        :..:.::.....       ::..|     |:...:.| :.|:
Zfish  1414 PASPKELPVPMIDVPVPLDDTPSKKKLVRSKNKKG-------IQDSEEPQVTLIEASSLPELPVN 1471

  Fly  1023 AHCRNIPIKT-----NESYICEECESGRLPLYGEIVWAKF----------NNFRWWPAIILP--- 1069
            ....::|.::     .|....|:.||....:..::....|          ...|.|..::|.   
Zfish  1472 NQYPDLPSESIKEEDGEPAFSEKEESQVPTIIPKVEETSFYVEEPIQKTRRQRRGWQELLLSMHS 1536

  Fly  1070 -------PTEVPSNILKKA--------HGENDFVVRFFG-THD--------HGWISRRRVYLYIE 1110
                   |:.:|.:..::.        .|.::..:|:.. |:|        |.|::..   |::.
Zfish  1537 PVASPRRPSFMPRSDFEEMTILYDIWNDGIDEEDIRYLKITYDKMLQQDNAHDWLNDT---LWVH 1598

  Fly  1111 -------GDTGDGHKTKSQLFRNYTTGV-----------EEASRFLPIIKARRQEQDMERQSGNK 1157
                   ..||...|.|....|::.||.           ::..::|...:.:.:|.|::.| |..
Zfish  1599 HPPTNMGSATGVKKKRKEDGIRDHVTGCARSEGYYKIDKKDKMKYLNSSRLQSEEPDVDTQ-GKS 1662

  Fly  1158 LHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCL--NRMLFNECNPEYCKAG 1220
            :...|.|..:....    |.|:....||:.:|          ::..|  |::.|.:....:|:: 
Zfish  1663 IPAQPQVSTRAGSE----RRSEQRRLLSSFSC----------DSDLLKFNQLKFRKKKIRFCRS- 1712

  Fly  1221 SLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRD 1285
                                 :...:||...||||..:.||||||:.|.......|.::.:.:..
Zfish  1713 ---------------------HIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGI 1756

  Fly  1286 ENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNY 1350
            .:.|...|:.|.||||...||.|||:||||.|||..:..||....::.|::.:.|.||.|:|::|
Zfish  1757 GSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSRQPINVNEEITYDY 1821

  Fly  1351 LWDDLMNNSKKACFCGAKRCSGEI 1374
            .:.  :.:.|..|.|||:.|.|.:
Zfish  1822 KFP--IEDEKIPCLCGAENCRGTL 1843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 15/116 (13%)
PHD2_NSD 867..932 CDD:277040 19/78 (24%)
PHD3_NSD 933..988 CDD:277041 10/62 (16%)
PHD4_NSD 1001..1041 CDD:277042 7/50 (14%)
WHSC1_related 1047..1141 CDD:99899 21/148 (14%)
AWS 1183..1233 CDD:197795 7/51 (14%)
SET 1234..1354 CDD:214614 42/119 (35%)
setd1baNP_001038599.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..58
RRM_SF 136..228 CDD:302621
RRM <144..>232 CDD:223796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..288
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..562 29/123 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..871 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 890..1108 51/306 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1160..1341 46/239 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1367..1499 25/149 (17%)
N-SET 1556..1695 CDD:288597 26/156 (17%)
SET <1619..1844 CDD:225491 68/264 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1647..1678 6/35 (17%)
SET 1705..1828 CDD:214614 43/146 (29%)
PostSET 1828..1844 CDD:214703 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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