DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD and nsd1b

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_005173940.1 Gene:nsd1b / 564592 ZFINID:ZDB-GENE-080519-2 Length:1873 Species:Danio rerio


Alignment Length:1605 Identity:397/1605 - (24%)
Similarity:647/1605 - (40%) Gaps:357/1605 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 NSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRL---LDKPGQNPVQNGAQPAAEES 84
            ||.|.|:.|.:.:........:.......|..:|.|:|.:::   :|.|..:.:.|||  ..:.:
Zfish   231 NSWSASVVAAEALLLEKPRVTSPSSAFKTISEETINNTEIKVSVPVDLPNSSFLINGA--VIQNN 293

  Fly    85 ELESQRQTPVQKQQQQ------RVS-MVNRKRDLINLQSALSPKY-------------------- 122
            .|.|.......|.:::      |:| .:|.::.:|  ..||...|                    
Zfish   294 HLNSLPHNRKSKNKKKPTISHCRISEELNCEKGMI--MDALDSPYSDIDSVPQIRRFPKSNEQIS 356

  Fly   123 ----IGYANAN-SPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGD 182
                |.|..:: :||.|..::|  :..::.|.....|..|..|:...:          |....|.
Zfish   357 NHYVINYKQSSATPTVLPSTND--KDVKKNVENQGGLWFSKTGKGQVN----------GISRAGI 409

  Fly   183 DSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVP-------- 239
            .|.|....|...    |:.:.:.||.........|.|.|...  .:|.:.|::|.:|        
Zfish   410 KSVNCSFGKVSC----KIKMPDSASMKPKDNHNTGLEHLSTE--AKKALDRRVKCLPASSRLMTR 468

  Fly   240 --KAKVTLELDEKNQQEVDEKSVKT---EPIDEEVDRTDEAPTQEAQTTAI-SIKSETEAEHKAA 298
              ||....|..:::..:::.|:..:   .|..|..|..:....|:..|.|| .:|.:::....|.
Zfish   469 ALKAMEDAEWTKESSSDLETKNCVSSFDSPSLETSDVHNSILLQKMPTAAIHDLKEDSKISTHAK 533

  Fly   299 V---------DVH-IKQEDTIRL--------------------DIVNNPVESTSIVITEEPKDLE 333
            :         |.| :|.||...|                    |:.::|..|..:.:    ||::
Zfish   534 LSSELLCCKDDEHSVKSEDESSLVSQAPCAFHSSTRKQNSHVNDLSSSPTPSLHLNL----KDMD 594

  Fly   334 KSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAK-GLSIVTDPGWPTYQVGD 397
             :..|::|.......:...|...|| |:...:|.:.....:.....| |..:|.:| .||.:   
Zfish   595 -NMNEISFKSLANEHSGQPLSFHPD-SNYKFSTFLMMLKDMHDSREKDGNVLVVEP-LPTTE--- 653

  Fly   398 LFWGKVFSYCFWPCMVCPDPL--GQIVGNMPSHPQRSSLDNANVPIQVHV-----RFFADNGRRN 455
                          ::..:||  ..:.....:..|:......||..:.|:     :....:.::.
Zfish   654 --------------LINEEPLLISDVKDEKATSKQKKVKPKTNVMSENHLASTISKTAQRSSKKI 704

  Fly   456 WIKPENLLTFAGL--KAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYS 518
            .:|.:.....|.:  |:||.:....|:........:...|||:.    |::..:.::....|...
Zfish   705 SLKKKTTDIKANIDYKSFDKLISAHRLTSKEAETNFSANVPKKR----WQKFDQVSEKTVHIVEG 765

  Fly   519 DRLEK--------------------FY--QTYENVVTLN-------------RQKRKRTKYMMQD 548
            :.:.|                    |:  :|..|.:..|             ::.||.:|.:::.
Zfish   766 NCIHKTERVSSENCDVSMDGTNKSCFFGPETTSNALECNQGNCQNTEAPTECKRIRKPSKRLIEW 830

  Fly   549 TSDVGSSLYD---STDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSK---NEKRAKRR--KLSN 605
            |.:     ||   |......|:...:..::.::...|.:..:..||.|   .|:...||  :|..
Zfish   831 TEE-----YDQLFSAKKKAKKKPDSVTKIENQKCSEPVAKTYDEVKQKPQVTEQDVSRRLPELQT 890

  Fly   606 GTEADTGSNSMAVT--PSQTETTVDSSAYENPE----------------FRQLLSAVMEYVMMN- 651
            ....|...::..:.  |.|....:.:.....|.                .||...||.:.|.:| 
Zfish   891 PPPEDQSQSTPLINTLPCQESQVLSAETLTPPPEIIPSPCDNISNRDQLQRQNPVAVGDSVCLNS 955

  Fly   652 -RSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMT 715
             |..:..:|:|.|      |::...:...:|.:.|.:|    .||.....|||   ::.|::...
Zfish   956 KRQRKPTKKILES------SIEAEPILIPKRKMKSMKI----CSSGHSTNSGV---EQQSSKSKN 1007

  Fly   716 MMVRRSMTPVVTPSTTPAPSEP-----DRRLSEPPKTKKPVNRPIEEVIEDILQ----------- 764
            .:...|..|         ||:|     :..:...|...:.:|....:...|.|:           
Zfish  1008 KLSIESSDP---------PSDPMLKSTEMEIDVSPAVLQTINTESADDGSDTLRCSGSQMTESSE 1063

  Fly   765 ---------------LDSKYLF--RGLS---REPICKYCYQAGSDLVRCSRTCSSWLHADCLERK 809
                           |||:.|.  :|.|   :|.:|..|.:.| ||:.|...|....|..|    
Zfish  1064 FYSEREENSQSDKVLLDSRRLSEEKGGSTSVKENVCPMCEKQG-DLLLCEGQCCGAFHPQC---- 1123

  Fly   810 VTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVE 874
             ||           |..|||.|                      .:|.||..| ...|..|.:  
Zfish  1124 -TG-----------LNEPPTGK----------------------FLCQECTSG-VHSCFACKR-- 1151

  Fly   875 SPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVS 939
                              :.:.:..|..|.|||.:|..|............:.|||.|.|.:|..
Zfish  1152 ------------------LGEDVRRCMVPGCGKFYHGECAASHAPTVPLNRAFRCPLHACLSCFI 1198

  Fly   940 DDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADA----HVNVL 1000
            .:|:.  ..:...:|.:|:|||..||....|||||:..|..:||:||.|...:...    ||||.
Zfish  1199 LNPAN--PSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHFTPRKGCRNHEHVNVS 1261

  Fly  1001 WCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPA 1065
            ||::|.:||.|:|||:||.|.|..|.||.:... |:.|.:|.:|:.|.|.|:||.|...:|||||
Zfish  1262 WCFVCSEGGSLLCCESCPAAFHRECLNIDMPEG-SWYCNDCRAGKKPHYKEVVWVKVGRYRWWPA 1325

  Fly  1066 IILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTG 1130
            .:..|.::|.|||:..|...:|.|.|||::|:.|..:.||:.|:|||.....|....:...|...
Zfish  1326 EVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGDANSKEKMGKGVDSTYKKA 1390

  Fly  1131 VEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAV-PPLRFSQNLEDLSTCNCLPVDE 1194
            ::||:.....::|.::.:.::....|...||||.:||.||.. ..|..|.:|.::..|||...||
Zfish  1391 LDEAALRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIISADLSEIPRCNCKATDE 1455

  Fly  1195 HPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDF 1259
            :|||.::.|:||||..||:|:.|.||..|:|:.|.:|:..::|......||:||.....|..|.|
Zfish  1456 NPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIKKGGF 1520

  Fly  1260 VIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKW 1324
            :.|||||||:..|.:.|::..|.:...|:|.|.::||.|||||||||.||||||.|:||||||||
Zfish  1521 ISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKW 1585

  Fly  1325 TVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK-----DDAVK 1384
            |||...|||:|::.|||..:||||||.. :.:.|.|..|.|||..|||.:|.:.|     ||..:
Zfish  1586 TVNGDTRVGLFSLTDIPAGTELTFNYNL-ECLGNGKTVCKCGASNCSGFLGVRPKNNPPSDDKGR 1649

  Fly  1385 AHAKLKQMRRAKASAVR---------------IHVKPKKTPKVKH 1414
               |||:.|:::...::               :..|....|||.|
Zfish  1650 ---KLKKKRKSQQEVIKEREDECFSCGDGGQIVSCKRPGCPKVYH 1691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 18/125 (14%)
PHD2_NSD 867..932 CDD:277040 12/64 (19%)
PHD3_NSD 933..988 CDD:277041 20/54 (37%)
PHD4_NSD 1001..1041 CDD:277042 18/39 (46%)
WHSC1_related 1047..1141 CDD:99899 34/93 (37%)
AWS 1183..1233 CDD:197795 23/49 (47%)
SET 1234..1354 CDD:214614 63/119 (53%)
nsd1bXP_005173940.1 PWWP 132..>204 CDD:321985
TOP2c <652..1020 CDD:330395 66/415 (16%)
PHD_SF 1098..1140 CDD:328929 18/80 (23%)
PHD_SF 1145..1191 CDD:328929 12/65 (18%)
PHD_SF 1193..1245 CDD:328929 20/53 (38%)
PHD4_NSD1 1262..1301 CDD:277126 18/39 (46%)
WHSC1_related 1307..1401 CDD:99899 34/93 (37%)
AWS 1444..1494 CDD:197795 23/49 (47%)
SET 1497..1618 CDD:214614 63/121 (52%)
PHD5_NSD1 1668..1710 CDD:277129 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 132 1.000 Domainoid score I5064
eggNOG 1 0.900 - - E2759_KOG1081
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 502 1.000 Inparanoid score I1322
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D38976at33208
OrthoFinder 1 1.000 - - FOG0001511
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102558
Panther 1 1.100 - - O PTHR22884
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X847
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1211.860

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