DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and ash1l

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_005159540.1 Gene:ash1l / 563799 ZFINID:ZDB-GENE-030131-6101 Length:2988 Species:Danio rerio


Alignment Length:2006 Identity:401/2006 - (19%)
Similarity:617/2006 - (30%) Gaps:804/2006 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 GNVLCN-SASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAA 81
            |:..|| ....|||:..:.:....|..:.:  |.|..|:.:..:| |.|.| |..|...|.|.|.
Zfish   465 GSTSCNIGLPGSLTSRPKASPSRIEDFSEK--DKERDREKDTDSP-RDLSK-GITPAITGKQDAK 525

  Fly    82 EESELESQR------QTPVQK--QQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSD 138
            |...|.:.|      .:||::  .|:.|||.|....:  :.:..:||.|...| :.||.||.|..
Zfish   526 ERCSLSAPRNDRGKSSSPVKRSPNQESRVSGVPSPAE--STKCTISPSYPSGA-SRSPPPLCDDT 587

  Fly   139 DTI----------------RTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGD---DS 184
            ..|                |..|.|..:|.:..:.|..|:.::....| ||...|.....   :|
Zfish   588 GAISPASPSEQDSKPLKKRRGRRPRWTKAVSRTHKSLHESPSNHQQIP-TPMPSGLSFSSPIRES 651

  Fly   185 ANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRV----------- 238
            ..|.||.:|.||.:..:..   |||...|          ||      |.||.|:           
Zfish   652 VEQPLSDSYTSPEDSDIFD---SSPKKRG----------RP------KTKMPRLDAPAHGCTPNK 697

  Fly   239 --PKAKVTLELDEKNQQ-------EVD--------------EKSVKTEPIDEEVDRTDEAPTQEA 280
              |....:..|..|.:|       |||              ::|..|.|      :..:.||...
Zfish   698 LAPSKSFSSLLKSKEEQDPPVLHPEVDFNPPKMMARKRGRPKRSPPTLP------QETQPPTLAP 756

  Fly   281 QTTAISIKSETEAEHKAAVDVHIKQEDTI-----RLDIVNNPVESTSIVITEEP-KDLEKSTEEL 339
            ::...|: .|....:|....:.:|   ||     ::..|......:.|::..:| ::.|.|....
Zfish   757 ESGEASV-GEKPFRNKGNGQLIMK---TIIGKINKMKTVKRKRLLSQILLGPKPAEEQECSRSSG 817

  Fly   340 AFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKG-------------LSIVTDPGWP 391
            ....|:|:       .|..|:|.|.....|....::: |.||             .|....||.|
Zfish   818 PTGSPVAT-------KPQSLTSLAATFGGKLGPQINV-SKKGTIYMGKRRGRKPKTSTNPSPGAP 874

  Fly   392 T----------------YQVGDLFWGKVFSYCFWPCMVCPDP-LGQIVG---------------- 423
            |                :||..|   :...:...|..|.|.| |.|..|                
Zfish   875 TPPPEPFLSPNTSSPHHHQVQAL---QNQPHQLPPSEVFPSPSLSQSSGGQSPISDASFVEPGSV 936

  Fly   424 NMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAK 488
            :..|||..|...      |||..|       ::..|    ||:...|...........| |...|
Zfish   937 HFSSHPHCSHSH------QVHHSF-------SFPPP----TFSAPSARSVASAATSTAH-PSQKK 983

  Fly   489 ------------------YRQMVPKRTKVVIWRQAIEEAQAMTQIPYSD-RLEKFYQTYENVVTL 534
                              ||:..|.|..:......:.|.:..|..|.|: ..|:...:...:.|.
Zfish   984 SSCRGYHHHHHHYRQHYHYRKFSPPRPLLPTSPAPLSELKEATPSPVSESHSEETVPSDSGIGTD 1048

  Fly   535 NRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLA----------------------VKRE 577
            |           ..|||.|... .|.:.|.....:|.:|                      .:|.
Zfish  1049 N-----------NSTSDRGEKA-GSANGLPGVGVSQGMAGGLLMPGVIGPGIGTGIGLSSRGRRR 1101

  Fly   578 RSESPF----SPAFSPV-----------------------KSKNEKRAKRRKLSNGTEADTGSNS 615
            .|.|..    ||..||:                       |.|::.:.|||  .:|         
Zfish  1102 HSSSVLLERPSPTPSPLGVRASPDPRRSHPAAPSSALVGHKEKHKHKCKRR--GHG--------- 1155

  Fly   616 MAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELE 680
               .||                         |..:.|...|.:|            |.:|||...
Zfish  1156 ---CPS-------------------------YDKLKRQKRKRKK------------KYLQLRSRR 1180

  Fly   681 RD---LASGEIEE-----------------PLGSSV-------VGRGSGVG-------------- 704
            :|   ||  :::|                 .||||:       .|||||:|              
Zfish  1181 QDPDFLA--DLDEICVQLSDIRISHRTPTLRLGSSIGLGAGAGPGRGSGLGSTRPSSSLGGGTNP 1243

  Fly   705 ------------TIKRL------------------------------------------------ 709
                        ||.|:                                                
Zfish  1244 PPHHYLHRDLLPTIFRINFSGYYSPHPAYPCDSLHYVRKPDLKKKRGRPPKLRESISEVPFVPGL 1308

  Fly   710 ------------------SNRLMTMMVRRSMTP--------------------VVTPSTTPAP-- 734
                              |:..:.:...|..||                    |.:||..|.|  
Zfish  1309 GFPLSSGGFYHPSYGVPYSSTPLGLGYYRGYTPPSALYPHPHHQAPHSGPSHHVHSPSFPPPPPP 1373

  Fly   735 -----SEPDRRLSEPPKTKKPVNRPIEEVI-----EDIL--QLDSKYLF---------------- 771
                 ..|...|..|.|..|..::.:.:..     ..:|  .:.|:..|                
Zfish  1374 SYVHHHHPSHLLLNPSKFHKKKHKLLRQEYLGGGRSSMLYPAMSSELSFGWHHKHKHRHKHRDRC 1438

  Fly   772 -----------------RGLSREPI---------------CKYCYQAGSDLVRCSRT-------- 796
                             ||:..|.:               |::.....:|    |||        
Zfish  1439 GEEEGDDGGGVLGGIGGRGVGGEGLGAGRGERGSVESLQHCRFGRDGSAD----SRTNKQSASAN 1499

  Fly   797 ---CSSWLHADCLERKVTGAPMPKIG-SRKALVIPPTSKSP--------SPDEDHVTADAKEVVA 849
               .||...|:..:||  .|.|..:| ||.:|........|        |.|.|:......:..:
Zfish  1500 SPSSSSTSSAERYKRK--EASMSCLGPSRLSLGTASRGHHPVDSWFRMGSSDTDYSKLSRNQSFS 1562

  Fly   850 ---------VGTSLVCHECN-------VGEPEGCVICHQ-----------------------VES 875
                     |...:.|.|.:       :.|||   |.|.                       :||
Zfish  1563 GSGAFSEGHVQNPVDCSESDEEDAASPIEEPE---ISHHTNLFASALSRTSLKGSRSKKGGPLES 1624

  Fly   876 PA---VPSTPRKEDSSSH--------TPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARC 929
            |:   :..|.|::.|:|.        :.:::::...|.|...:..|.....:.....|..|:|.|
Zfish  1625 PSLSRLDRTVRRDRSTSSEKREIGNVSSLQNRVGQSSVPDVSEGLHHRHHHHHHPPLSLSHAASC 1689

  Fly   930 PRHVCHTCVSDDPSGKFQQLGSSKLAK----------CVRCPATYHQLSKCIPAGTQMLNTTNII 984
            ..|    |..|.|........||:.|.          |:..|.::  ||...|....:|:...|:
Zfish  1690 LPH----CTLDQPGNTAPLRPSSRQASPSTCSSQPACCLDSPPSH--LSHRPPPKNNLLHVNKIL 1748

  Fly   985 ----------------------CPRHN------------IAKADAH-------VNVLWCYICVKG 1008
                                  .||.|            .::.|.|       ...||       
Zfish  1749 RAKKLQRQARTGNNMVKKRGPGRPRKNPLPSPPATPPPQTSEQDNHPLPERHRATALW------- 1806

  Fly  1009 GELVCCETCPIAVHAHCRNIPIKTNESYICE-ECESG---------RLPLYGEIVWAKFNNFRWW 1063
                ..:|...|:.|..:|...|..:....| |.|.|         ...:..|            
Zfish  1807 ----EADTVVDAIEAVVQNQRKKGRKRKHWERETEGGDEEEEDAEEERQVEDE------------ 1855

  Fly  1064 PAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLY---IEGDT------------ 1113
                 ...|......:.|..|:|.:.|........|:::..|:.:   :||..            
Zfish  1856 -----EEEEDEEQEQQSAAREDDVMSRVRTEGSRQWLTQEEVHCFRSALEGKPDGSPERPGPATS 1915

  Fly  1114 ------------------------------GDGHKT---KSQLFR------NYTTGVEEASRFLP 1139
                                          .|.:||   :|||.:      .||.| |.....||
Zfish  1916 EPTPNPSVTSQREKRVARPPKKKFQKAGLYSDVYKTDDPRSQLLQLKKEKLEYTPG-EHDYGLLP 1979

  Fly  1140 ----IIKARRQEQ-DME-----------RQSGNKLHPPPYVKIKTN--KAVPPLRFSQNLEDLST 1186
                :.|..||:: |.:           .|...:...|.|.||::|  ..|.||    :..:.:|
Zfish  1980 APIHVGKYLRQKRIDFQLPYDILWLWKHDQLYKRPDVPLYKKIRSNVYVDVKPL----SGYEATT 2040

  Fly  1187 CNC-LPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPR-LEVVYMNERGFGLV 1249
            ||| ||.|....|.:..|||||::.||:|..|.....|:|:..::.:..: ||......:|:|:.
Zfish  2041 CNCRLPDDSSEKGCQDDCLNRMIYAECSPSTCPCSDQCDNQRIQKHEWVQCLERFRAEGKGWGIR 2105

  Fly  1250 NREPIAVGDFVIEYVGEVINHAEFQR------RMEQ-------------------KQRDRDENYY 1289
            .::|:..|.|:|||:|||::..||::      |:.|                   :|......:|
Zfish  2106 TKQPLRAGQFIIEYLGEVVSEQEFRKYIASDCRLHQVKIPMLGENKKQIGVSRMMEQYFSHSGHY 2170

  Fly  1290 FLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDD 1354
            .|.::...:||:...||.|||:|||||||||.|||:||.::|:|:||:|||...:|||::|.:..
Zfish  2171 CLNLDSGMVIDSYRMGNEARFVNHSCEPNCEMQKWSVNGVYRIGLFALKDINSGTELTYDYNFHS 2235

  Fly  1355 LMNNSKKACFCGAKRCSGEIGGKLK------------DDAVKAHAKLKQMRRAKAS 1398
            .....::.|.||::.|.|.||||.|            ....:...:||:.|::|.|
Zfish  2236 FNTEEQQVCKCGSEGCRGIIGGKSKRINGLPAKGAGSGGGARRLGRLKEKRKSKHS 2291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 31/167 (19%)
PHD2_NSD 867..932 CDD:277040 16/98 (16%)
PHD3_NSD 933..988 CDD:277041 14/86 (16%)
PHD4_NSD 1001..1041 CDD:277042 7/40 (18%)
WHSC1_related 1047..1141 CDD:99899 22/151 (15%)
AWS 1183..1233 CDD:197795 19/50 (38%)
SET 1234..1354 CDD:214614 52/145 (36%)
ash1lXP_005159540.1 CytochromB561_N <529..>674 CDD:286826 38/151 (25%)
AWS 2037..2088 CDD:197795 19/50 (38%)
SET 2091..2238 CDD:214614 52/146 (36%)
COG5076 2281..>2500 CDD:227408 5/11 (45%)
Bromo_ASH1 2408..2513 CDD:99955
PHD_ASH1L 2559..2601 CDD:277023
BAH_polybromo 2633..2772 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.950

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